Liquiritigenin promotes osteogenic differentiation and prevents bone loss via inducing auto-lysosomal degradation and inhibiting apoptosis

Autor: Yu Qiu, Yueyang Zhao, Zhimin Long, Aijia Song, Peng Huang, Kejian Wang, Ling Xu, David Paul Molloy, Guiqiong He

Publikováno v: Genes and Diseases, Vol 10, Iss 1, Pp 284-300 (2023)

Osteoporosis (OP) is a debilitating skeletal abnormality involving bone remodeling and bone cell homeostasis characterized by decreased bone strength and high fracture risk. A novel therapeutic intervention for OP by manipulating cellular autophagy�

Externí odkaz: https://doaj.org/article/d5ec4adb654c40c1b38b85bf3031ea88

Liquiritigenin promotes osteogenic differentiation and prevents bone loss via inducing auto-lysosomal degradation and inhibiting apoptosis.

Autor: Qiu Y; College of Stomatology, Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 400016, China.; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China., Zhao Y; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China.; Department of Anatomy, Chongqing Medical University, Chongqing 400016, China., Long Z; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China.; Department of Anatomy, Chongqing Medical University, Chongqing 400016, China., Song A; Laboratory of Medical Experiment Technology, Institute of Life Science, Chongqing Medical University, Chongqing 400016, China., Huang P; Laboratory of Medical Experiment Technology, Institute of Life Science, Chongqing Medical University, Chongqing 400016, China., Wang K; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China.; Department of Anatomy, Chongqing Medical University, Chongqing 400016, China., Xu L; College of Stomatology, Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 400016, China., Molloy DP; Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing 400016, China., He G; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China.; Department of Anatomy, Chongqing Medical University, Chongqing 400016, China.

Publikováno v: Genes & diseases [Genes Dis] 2021 Jul 13; Vol. 10 (1), pp. 284-300. Date of Electronic Publication: 2021 Jul 13 (Print Publication: 2023).