Výsledky vyhledávání - "Austyn Orvis"

Akademický článek

GBS hyaluronidase mediates immune suppression in a TLR2/4- and IL-10-dependent manner during pregnancy-associated infection

Autor: Michelle Coleman, Austyn Orvis, Alyssa Brokaw, Anna Furuta, Kavita Sharma, Phoenicia Quach, Avneet Bhullar, Rhea Sanghavi, Shayla Nguyen, Erin Sweeney, Ravin Seepersaud, Blair Armistead, Kristina M. Adams Waldorf, Lakshmi Rajagopal

Publikováno v: mBio, Vol 14, Iss 5 (2023)

ABSTRACT Bacterial infections remain a significant cause of adverse pregnancy outcomes. Ascending infection of group B streptococcus (GBS) or Streptococcus agalactiae from the lower genital tract to the amniotic cavity leads to fetal injury, preterm

Externí odkaz: https://doaj.org/article/c67d21d4ebf64cc49db64cc57489628f

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Akademický článek

Virulence, phenotype and genotype characteristics of invasive group B Streptococcus isolates obtained from Swedish pregnant women and neonates

Publikováno v: Annals of Clinical Microbiology and Antimicrobials, Vol 21, Iss 1, Pp 1-14 (2022)

Abstract Group B streptococci (GBS) are bacteria that can cause preterm birth and invasive neonatal disease. Heterogeneous expression of virulence factors enables GBS to exist as both commensal bacteria and to become highly invasive. A molecular epid

Externí odkaz: https://doaj.org/article/5d0e2b208ed44c898e5144bb5ccb2897

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Akademický článek

Mast cell–derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)

Invasive bacterial infections remain a major cause of human morbidity. Group B streptococcus (GBS) are Gram-positive bacteria that cause invasive infections in humans. Here, we show that factor XIIIA–deficient (FXIIIA-deficient) female mice exhibit

Externí odkaz: https://doaj.org/article/333d9ff9ad8b4e0e97c66e4897ce00b5

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Akademický článek

Hyaluronidase Impairs Neutrophil Function and Promotes Group B Streptococcus Invasion and Preterm Labor in Nonhuman Primates

Autor: Michelle Coleman, Blair Armistead, Austyn Orvis, Phoenicia Quach, Alyssa Brokaw, Claire Gendrin, Kavita Sharma, Jason Ogle, Sean Merillat, Matthew Dacanay, Tsung-Yen Wu, Jeff Munson, Audrey Baldessari, Jay Vornhagen, Anna Furuta, Shayla Nguyen, Kristina M. Adams Waldorf, Lakshmi Rajagopal

Publikováno v: mBio, Vol 12, Iss 1 (2021)

Group B streptococci (GBS) are bacteria that commonly reside in the female lower genital tract as asymptomatic members of the microbiota. However, during pregnancy, GBS can infect tissues at the maternal-fetal interface, leading to preterm birth, sti

Externí odkaz: https://doaj.org/article/e8b9aaec47134d77a586d9f927ccda52

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Akademický článek

A Broad Spectrum Chemokine Inhibitor Prevents Preterm Labor but Not Microbial Invasion of the Amniotic Cavity or Neonatal Morbidity in a Non-human Primate Model

Autor: Michelle Coleman, Austyn Orvis, Tsung-Yen Wu, Matthew Dacanay, Sean Merillat, Jason Ogle, Audrey Baldessari, Nicole M. Kretzer, Jeff Munson, Adam J. Boros-Rausch, Oksana Shynlova, Stephen Lye, Lakshmi Rajagopal, Kristina M. Adams Waldorf

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Leukocyte activation within the chorioamniotic membranes is strongly associated with inflammation and preterm labor (PTL). We hypothesized that prophylaxis with a broad-spectrum chemokine inhibitor (BSCI) would downregulate the inflammatory microenvi

Externí odkaz: https://doaj.org/article/619350db505e447abea1a049a5ff98a9

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Mast cell-derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections

Publikováno v: The Journal of clinical investigation. 132(20)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06dc85c4d627c5b0b93c3643558cb23d
https://pubmed.ncbi.nlm.nih.gov/36006736

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Hyaluronidase Impairs Neutrophil Function and Promotes Group B Streptococcus Invasion and Preterm Labor in Nonhuman Primates

Autor: Tsung-Yen Wu, Kavita Sharma, Michelle Coleman, Claire Gendrin, Jeff Munson, Phoenicia Quach, Jason Ogle, Blair Armistead, Shayla Nguyen, Kristina M. Adams Waldorf, Austyn Orvis, Matthew Dacanay, Alyssa Brokaw, Jay Vornhagen, Sean Merillat, Anna Furuta, Lakshmi Rajagopal, Audrey Baldessari

Publikováno v: mBio, Vol 12, Iss 1 (2021)

Invasive bacterial infections during pregnancy are a major risk factor for preterm birth, stillbirth, and fetal injury. Group B streptococci (GBS) are Gram-positive bacteria that asymptomatically colonize the lower genital tract but infect the amniot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a2cc5f79e2252a941853be56b050cb
https://journals.asm.org/doi/10.1128/mBio.03115-20

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Amniotic fluid interleukin 6 and interleukin 8 are superior predictors of fetal lung injury compared with maternal or fetal plasma cytokines or placental histopathology in a nonhuman primate model

Autor: Stephen A. McCartney, H. Denny Liggitt, Raj P. Kapur, Lakshmi Rajagopal, Jason Ogle, Audrey Baldessari, Kristina M. Adams Waldorf, Ronit Katz, Michelle Coleman, Austyn Orvis

Publikováno v: Am J Obstet Gynecol

Background Intra-amniotic infection or inflammation is common in early preterm birth and associated with substantial neonatal lung morbidity owing to fetal exposure to proinflammatory cytokines and infectious organisms. Amniotic fluid interleukin 8,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22424ca13a1f4a58c7eb29f9810a72df
https://doi.org/10.1016/j.ajog.2020.12.1214

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