Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Austin Zimmet"'
Autor:
Fred E. Fregoso, Trevor van Eeuwen, Gleb Simanov, Grzegorz Rebowski, Malgorzata Boczkowska, Austin Zimmet, Alexis M. Gautreau, Roberto Dominguez
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The Arp2/3 complex inhibitor Arpin controls cell migration by interrupting a feedback loop involving Rac-WAVE-Arp2/3 complex Here, the authors use structural, biochemical, and cellular studies to reveal Arpin’s mechanism of inhibition.
Externí odkaz:
https://doaj.org/article/6a8063234c014575b26daa0160bba64f
Autor:
Fred E. Fregoso, Alexis M. Gautreau, Roberto Dominguez, Grzegorz Rebowski, Malgorzata Boczkowska, Trevor van Eeuwen, Gleb Simanov, Austin Zimmet
Positive feedback loops involving signaling and actin assembly factors mediate the formation and remodeling of branched actin networks in processes ranging from cell and organelle motility to mechanosensation. The Arp2/3 complex inhibitor Arpin contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce9fa0c9d0f2f81fcd6634f72e44b0ba
https://doi.org/10.1101/2021.10.30.466598
https://doi.org/10.1101/2021.10.30.466598
Autor:
Trevor van Eeuwen, Roberto Dominguez, Austin Zimmet, Grzegorz Rebowski, Malgorzata Boczkowska, Kenji Murakami
Publikováno v:
Science Advances
A cryo-EM structure and functional study show that Arp2/3 complex activation requires NPF-mediated delivery of actin to both Arps.
Actin-related protein (Arp) 2/3 complex nucleates branched actin networks that drive cell motility. It consists of
Actin-related protein (Arp) 2/3 complex nucleates branched actin networks that drive cell motility. It consists of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd697af6342c1af80167eef2fead6f3
https://doi.org/10.1126/sciadv.aaz7651
https://doi.org/10.1126/sciadv.aaz7651
Publikováno v:
The Journal of Organic Chemistry. 81:3528-3532
An improved synthesis of the bis-methylamido Hantzsch dihydropyridine is described. The Hantzsch amide is demonstrated to be an effective transfer hydrogenation reagent using α,β-unsaturated ketones as the test case. Unreacted Hantzsch amide and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290364f5881f56b972ac597dd4481384
https://doi.org/10.1021/acs.joc.6b00041
https://doi.org/10.1021/acs.joc.6b00041
Autor:
Robert G. Alberstein, Alvin Yu, Albert Y. Lau, Austin Zimmet, Mark L. Mayer, Richard Grey, Alecia Thomas
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(44)
The earliest metazoan ancestors of humans include the ctenophore Mnemiopsis leidyi. The genome of this comb jelly encodes homologs of vertebrate ionotropic glutamate receptors (iGluRs) that are distantly related to glycine-activated NMDA receptors an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3ac8f56b77bb1e096824a951dece71
https://pubmed.ncbi.nlm.nih.gov/27791085
https://pubmed.ncbi.nlm.nih.gov/27791085
Recent genome projects for ctenophores have revealed the presence of numerous ionotropic glutamate receptors (iGluRs) in Mnemiopsis leidyi and Pleurobrachia bachei, among our earliest metazoan ancestors. Sequence alignments and phylogenetic analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c5069cfdc9984ff9fa9a36e4465e3d
https://europepmc.org/articles/PMC4640758/
https://europepmc.org/articles/PMC4640758/