Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Austin W. T. Chiang"'
Autor:
Benjamin P. Kellman, Anne Richelle, Jeong-Yeh Yang, Digantkumar Chapla, Austin W. T. Chiang, Julia A. Najera, Chenguang Liang, Annalee Fürst, Bokan Bao, Natalia Koga, Mahmoud A. Mohammad, Anders Bech Bruntse, Morey W. Haymond, Kelley W. Moremen, Lars Bode, Nathan E. Lewis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Human milk oligosaccharides are fundamental to infant health. Here the authors deploy a multi-omics systems biology approach to elucidate their biosynthetic network, including the associated enzymes and likely structures of ambiguous oligosaccharides
Externí odkaz:
https://doaj.org/article/a121fe2e64dd462990db15ec4c5f9e07
Autor:
Bokan Bao, Benjamin P. Kellman, Austin W. T. Chiang, Yujie Zhang, James T. Sorrentino, Austin K. York, Mahmoud A. Mohammad, Morey W. Haymond, Lars Bode, Nathan E. Lewis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Glycomics can uncover important molecular changes but measured glycans are highly interconnected and incompatible with common statistical methods, introducing pitfalls during analysis. Here, the authors develop an approach to identify glycan dependen
Externí odkaz:
https://doaj.org/article/0266f2430f0749aa86d6452e4b2f41e3
Autor:
Austin W. T. Chiang, Hratch M. Baghdassarian, Benjamin P. Kellman, Bokan Bao, James T. Sorrentino, Chenguang Liang, Chih-Chung Kuo, Helen O. Masson, Nathan E. Lewis
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-15 (2021)
Abstract Cancer immunotherapy has revolutionized treatment and led to an unprecedented wave of immuno-oncology research during the past two decades. In 2018, two pioneer immunotherapy innovators, Tasuku Honjo and James P. Allison, were awarded the No
Externí odkaz:
https://doaj.org/article/1effcf77853041a2abacd227d52e50a8
Autor:
Benjamin P. Kellman, Yujie Zhang, Emma Logomasini, Eric Meinhardt, Karla P. Godinez-Macias, Austin W. T. Chiang, James T. Sorrentino, Chenguang Liang, Bokan Bao, Yusen Zhou, Sachiko Akase, Isami Sogabe, Thukaa Kouka, Elizabeth A. Winzeler, Iain B. H. Wilson, Matthew P. Campbell, Sriram Neelamegham, Frederick J. Krambeck, Kiyoko F. Aoki-Kinoshita, Nathan E. Lewis
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2645-2662 (2020)
Systems glycobiology aims to provide models and analysis tools that account for the biosynthesis, regulation, and interactions with glycoconjugates. To facilitate these methods, there is a need for a clear glycan representation accessible to both com
Externí odkaz:
https://doaj.org/article/d2673eab9e7b4440a013dfc392b24604
Autor:
Stefan Kol, Daniel Ley, Tune Wulff, Marianne Decker, Johnny Arnsdorf, Sanne Schoffelen, Anders Holmgaard Hansen, Tanja Lyholm Jensen, Jahir M. Gutierrez, Austin W. T. Chiang, Helen O. Masson, Bernhard O. Palsson, Bjørn G. Voldborg, Lasse Ebdrup Pedersen, Helene Faustrup Kildegaard, Gyun Min Lee, Nathan E. Lewis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Host cell proteins can contaminate biotherapeutics and compromise and degrade their quality. Here the authors use modelling and CRISPR to delete secreted host proteins in CHO cells, leading to improved monoclonal antibody production and purity.
Externí odkaz:
https://doaj.org/article/fb48699f0dc94c81a1ca056457c7fde6
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Proteome-scale bioinformatics research is increasingly conducted as the number of completely sequenced genomes increases, but analysis of protein domains (PDs) usually relies on similarity in their amino acid sequences and/or three-dimension
Externí odkaz:
https://doaj.org/article/2b8ec53997fe4196aaff8ed8790d6336
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006867 (2019)
Genome-scale metabolic models provide a valuable context for analyzing data from diverse high-throughput experimental techniques. Models can quantify the activities of diverse pathways and cellular functions. Since some metabolic reactions are only c
Externí odkaz:
https://doaj.org/article/4db974a075c24013b6bcf26e0e351ec6
Autor:
Lars Bode, Austin W. T. Chiang, Morey W. Haymond, Natalia Koga, Benjamin P. Kellman, Jeong-Yeh Yang, Nathan E. Lewis, Anne Richelle, Kelley W. Moremen, Julia A Najera, Digantkumar Chapla, Mahmoud A. Mohammad, Anders Bech Bruntse, Bokan Bao
Publikováno v:
Nature communications, vol 13, iss 1
Human Milk Oligosaccharides (HMOs) are abundant carbohydrates fundamental to infant health and development. Although these oligosaccharides were discovered more than half a century ago, their biosynthesis in the mammary gland remains largely uncharac
Autor:
Johnny Arnsdorf, Chenguang Liang, Bjørn G. Voldborg, Benjamin P. Kellman, Bokan Bao, Anders Holmgaard Hansen, Nathan E. Lewis, James T. Sorrentino, Austin W. T. Chiang, Sanne Schoffelen
Publikováno v:
Current Research in Biotechnology, Vol 2, Iss, Pp 22-36 (2020)
Liang, C, Chiang, A W T, Hansen, A H, Arnsdorf, J, Schoffelen, S, Sorrentino, J T, Kellman, B P, Bao, B, Voldborg, B G & Lewis, N E 2020, ' A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering ', Current Research in Biotechnology, vol. 2, pp. 22-36 . https://doi.org/10.1016/j.crbiot.2020.01.001
Curr Res Biotechnol
Liang, C, Chiang, A W T, Hansen, A H, Arnsdorf, J, Schoffelen, S, Sorrentino, J T, Kellman, B P, Bao, B, Voldborg, B G & Lewis, N E 2020, ' A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering ', Current Research in Biotechnology, vol. 2, pp. 22-36 . https://doi.org/10.1016/j.crbiot.2020.01.001
Curr Res Biotechnol
Glycosylated biopharmaceuticals are important in the global pharmaceutical market. Despite the importance of their glycan structures, our limited knowledge of the glycosylation machinery still hinders controllability of this critical quality attribut
Autor:
Matthew Paul Campbell, Sriram Neelamegham, Karla P. Godinez-Macias, Isami Sogabe, Yujie Zhang, Thukaa Kouka, James T. Sorrentino, Yusen Zhou, Iain B. H. Wilson, Eric Meinhardt, Austin W. T. Chiang, Frederick J. Krambeck, Benjamin P. Kellman, Kiyoko F. Aoki-Kinoshita, Elizabeth A. Winzeler, Nathan E. Lewis, Chenguang Liang, Emma Logomasini, Sachiko Akase, Bokan Bao
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2645-2662 (2020)
Beilstein journal of organic chemistry, vol 16, iss 1
Beilstein journal of organic chemistry, vol 16, iss 1
Systems glycobiology aims to provide models and analysis tools that account for the biosynthesis, regulation, and interactions with glycoconjugates. To facilitate these methods, there is a need for a clear glycan representation accessible to both com