Výsledky vyhledávání - "Austin Reuter"

Akademický článek

Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E2 Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes

Autor: Michael D. Schaid, Yanlong Zhu, Nicole E. Richardson, Chinmai Patibandla, Irene M. Ong, Rachel J. Fenske, Joshua C. Neuman, Erin Guthery, Austin Reuter, Harpreet K. Sandhu, Miles H. Fuller, Elizabeth D. Cox, Dawn B. Davis, Brian T. Layden, Allan R. Brasier, Dudley W. Lamming, Ying Ge, Michelle E. Kimple

Publikováno v: Metabolites, Vol 11, Iss 1, p 58 (2021)

The transition from β-cell compensation to β-cell failure is not well understood. Previous works by our group and others have demonstrated a role for Prostaglandin EP3 receptor (EP3), encoded by the Ptger3 gene, in the loss of functional β-cell ma

Externí odkaz: https://doaj.org/article/38bb3f22b05b403c9dc9ec32fcc5ca99

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RF04 | PSUN135 Genetic Inactivation of Glutaminase Reduces Amino Acid Induced Alpha Cell Proliferation

Autor: Matthew Shou, Walter Siv, Joshua Debo, Katelyn Sellick, Austin Reuter, Jade E Stanley, E Danielle Dean

Publikováno v: Journal of the Endocrine Society. 6:A417-A417

Glucagon stimulates glycogenolysis and gluconeogenesis in liver resulting in increased hepatic glucose output. Thus, interrupting glucagon signaling in liver reduces blood glucose levels in animal models and individuals with diabetes. However, interr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc74f861fcb218fc611ef8a44d5caaf7
https://doi.org/10.1210/jendso/bvac150.868

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181-OR: Amino Acid-Stimulated Alpha Cell Proliferation Requires Glutaminase Activity

Autor: Wenbiao Chen, Matthew Shou, Walter Siv, Danielle Dean, Austin Reuter, Katelyn Sellick, Erick Spears, Jade Stanley

Publikováno v: Diabetes. 70

Interrupted glucagon signaling reduces hyperglycemia. However, interrupted glucagon signaling increases serum amino acid and glucagon levels and stimulates amino acid-dependent alpha cell proliferation as part of an endocrine feedback loop, the liver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f861ff6df8a4d711254a33a36f0b91e1
https://doi.org/10.2337/db21-181-or

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The protection of Gαz-null NOD mice from hyperglycemia is sexually dimorphic and only partially β-cell autonomous

Autor: Schaid, Michelle E. Kimple, Haley Wienkes, Austin Reuter, Darby C. Peter, Kathryn A. Carbajal, Rachel J. Fenske

The mechanisms that underlie the β-cell pathophysiology of Type 1 Diabetes (T1D) are not fully understood. Our group has defined the unique heterotrimeric G protein alpha-subunit, Gαz, as a key negative regulator of β-cell signal transduction path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a350f9cf18378e834e7b86d4415f3b2
https://doi.org/10.1101/2021.02.08.430304

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Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E2 Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes

Autor: Brian T. Layden, Elizabeth D. Cox, Miles H Fuller, Erin Guthery, Yanlong Zhu, Chinmai Patibandla, Michael D. Schaid, Austin Reuter, Dudley W. Lamming, Joshua C. Neuman, Rachel J. Fenske, Michelle E. Kimple, Nicole E. Richardson, Ying Ge, Harpreet K Sandhu, Dawn Belt Davis, Irene M. Ong, Allan R. Brasier

Publikováno v: Metabolites
Volume 11
Issue 1
Metabolites, Vol 11, Iss 58, p 58 (2021)

The transition from &beta
cell compensation to &beta
cell failure is not well understood. Previous works by our group and others have demonstrated a role for Prostaglandin EP3 receptor (EP3), encoded by the Ptger3 gene, in the loss of funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77db8677ac2990b7361568d41c813468

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Prostaglandin EP3 Receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance

Autor: Darby C. Peter, Rachel J. Fenske, Michelle E. Kimple, Michael D. Schaid, Austin Reuter, Jaclyn A. Wisinski

Publikováno v: Am J Physiol Endocrinol Metab

When homozygous for the LeptinOb mutation (Ob), Black-and-Tan Brachyury (BTBR) mice become morbidly obese and severely insulin resistant, and by 10 weeks of age, frankly diabetic. Previous work has shown Prostaglandin EP3 Receptor (EP3) expression an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5f5852f556721b968e27813fa64523
https://doi.org/10.1101/671289

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Differential Effects of Prostaglandin E2 Production and Signaling through the Prostaglandin EP3 Receptor on Human Beta-cell Compensation

Autor: Nathan A. Truchan, Buchanan R, Austin Reuter, Harpreet K Sandhu, Rachel J. Fenske, Michelle E. Kimple, Jeffrey M. Harrington, Moeller J

ObjectiveSignaling through Prostaglandin E3 Receptor (EP3), a G protein-coupled receptor for E series prostaglandins such as prostaglandin E2(PGE2), has been linked to the beta-cell dysfunction and loss of beta-cell mass in type 2 diabetes (T2D). In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95d5df1b5668095b178d7356a6e3122

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