Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Austin R. Dosch"'
Autor:
Anna Bianchi, Iago De Castro Silva, Nilesh U. Deshpande, Samara Singh, Siddharth Mehra, Vanessa T. Garrido, Xinyu Guo, Luis A. Nivelo, Despina S. Kolonias, Shannon J. Saigh, Eric Wieder, Christine I. Rafie, Austin R. Dosch, Zhiqun Zhou, Oliver Umland, Haleh Amirian, Ifeanyichukwu C. Ogobuiro, Jian Zhang, Yuguang Ban, Carina Shiau, Nagaraj S. Nagathihalli, Elizabeth A. Montgomery, William L. Hwang, Roberta Brambilla, Krishna Komanduri, Alejandro V. Villarino, Eneda Toska, Ben Z. Stanger, Dmitry I. Gabrilovich, Nipun B. Merchant, Jashodeep Datta
Publikováno v:
Cancer Discovery. :OF1-OF26
We have shown that KRAS–TP53 genomic coalteration is associated with immune-excluded microenvironments, chemoresistance, and poor survival in pancreatic ductal adenocarcinoma (PDAC) patients. By treating KRAS–TP53 cooperativity as a model for hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a8514d00373d52b2132f03e694ed4e3
https://doi.org/10.1158/2159-8290.cd-22-1046
https://doi.org/10.1158/2159-8290.cd-22-1046
Autor:
Jashodeep Datta, Nipun B. Merchant, Dmitry I. Gabrilovich, Ben Z. Stanger, Eneda Toska, Alejandro V. Villarino, Krishna Komanduri, Roberta Brambilla, William L. Hwang, Elizabeth A. Montgomery, Nagaraj S. Nagathihalli, Carina Shiau, Yuguang Ban, Jian Zhang, Ifeanyichukwu C. Ogobuiro, Haleh Amirian, Oliver Umland, Zhiqun Zhou, Austin R. Dosch, Christine I. Rafie, Eric Wieder, Shannon J. Saigh, Despina S. Kolonias, Luis A. Nivelo, Xinyu Guo, Vanessa T. Garrido, Siddharth Mehra, Samara Singh, Nilesh U. Deshpande, Iago De Castro Silva, Anna Bianchi
We have shown that KRAS–TP53 genomic coalteration is associated with immune-excluded microenvironments, chemoresistance, and poor survival in pancreatic ductal adenocarcinoma (PDAC) patients. By treating KRAS–TP53 cooperativity as a model for hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c006c946ca4358d4c3811305ca5a79
https://doi.org/10.1158/2159-8290.c.6655455.v1
https://doi.org/10.1158/2159-8290.c.6655455.v1
Autor:
Jashodeep Datta, Nipun B. Merchant, Dmitry I. Gabrilovich, Ben Z. Stanger, Eneda Toska, Alejandro V. Villarino, Krishna Komanduri, Roberta Brambilla, William L. Hwang, Elizabeth A. Montgomery, Nagaraj S. Nagathihalli, Carina Shiau, Yuguang Ban, Jian Zhang, Ifeanyichukwu C. Ogobuiro, Haleh Amirian, Oliver Umland, Zhiqun Zhou, Austin R. Dosch, Christine I. Rafie, Eric Wieder, Shannon J. Saigh, Despina S. Kolonias, Luis A. Nivelo, Xinyu Guo, Vanessa T. Garrido, Siddharth Mehra, Samara Singh, Nilesh U. Deshpande, Iago De Castro Silva, Anna Bianchi
Differentially expressed pathways comparing transcriptomes in KRAS-TP53 co-altered (n=23) and KRAS-altered/TP53WT (n=5) derived from Cancer Cell Line Encyclopedia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92246783d8a78ae68e4fcb7019f7aad2
https://doi.org/10.1158/2159-8290.22960614
https://doi.org/10.1158/2159-8290.22960614
Autor:
Jashodeep Datta, Nipun B. Merchant, Dmitry I. Gabrilovich, Ben Z. Stanger, Eneda Toska, Alejandro V. Villarino, Krishna Komanduri, Roberta Brambilla, William L. Hwang, Elizabeth A. Montgomery, Nagaraj S. Nagathihalli, Carina Shiau, Yuguang Ban, Jian Zhang, Ifeanyichukwu C. Ogobuiro, Haleh Amirian, Oliver Umland, Zhiqun Zhou, Austin R. Dosch, Christine I. Rafie, Eric Wieder, Shannon J. Saigh, Despina S. Kolonias, Luis A. Nivelo, Xinyu Guo, Vanessa T. Garrido, Siddharth Mehra, Samara Singh, Nilesh U. Deshpande, Iago De Castro Silva, Anna Bianchi
Co-occupied and unique target genes shared between Creb and RNApol-II in chromatin immunoprecipitation and sequencing (ChIP-seq) experiments performed in murine Kras-Trp53 cooperative KPC pancreatic cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d796dc0566c9b1cfd9f20de3af40f14
https://doi.org/10.1158/2159-8290.22960611
https://doi.org/10.1158/2159-8290.22960611
Autor:
Nagaraj S. Nagathihalli, Nipun B. Merchant, Richard Caprioli, Nilesh Kashikar, Deukwoo Kwon, Brent A. Willobee, Supriya Srinivasan, Siddharth Mehra, Michelle L. Reyzer, Xizi Dai, Austin R. Dosch
MALDI-IMS analysis of treated xenograft tissues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf97332aeb092976dc13880ff7c77bc
https://doi.org/10.1158/1541-7786.22515234
https://doi.org/10.1158/1541-7786.22515234
Data from Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer
Autor:
Nagaraj S. Nagathihalli, Nipun B. Merchant, Michael VanSaun, Nilesh Kashikar, Deukwoo Kwon, Xi Chen, Praveen Kumar Vemula, Jason Castellanos, Shobith Rangappa, Chandrashekhar Joshi, Alexander A. Gaidarski, Austin R. Dosch, Purushottam Lamichhane, Venkatakrishna R. Jala, Supriya Srinivasan, Tulasigeri M. Totiger
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy and is highly resistant to standard treatment regimens. Targeted therapies against KRAS, a mutation present in an overwhelming majority of PDAC cases, have been largely ineffective.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d86cd7745b570e1436e2187856b939f
https://doi.org/10.1158/1535-7163.c.6538780
https://doi.org/10.1158/1535-7163.c.6538780
Autor:
Nipun B. Merchant, Nagaraj S. Nagathihalli, Michael N. VanSaun, Supriya Srinivasan, Fanuel Messaggio, Siddharth Mehra, Xizi Dai, Jason A. Castellanos, Austin R. Dosch, Alexander A. Gaidarski, Brent A. Willobee
Activating KRAS mutations, a defining feature of pancreatic ductal adenocarcinoma (PDAC), promote tumor growth in part through the activation of cyclin-dependent kinases (CDK) that induce cell-cycle progression. p16INK4a (p16), encoded by the gene CD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5d9c09b3adba2ed90046e599fd9fc4
https://doi.org/10.1158/1535-7163.c.6543223
https://doi.org/10.1158/1535-7163.c.6543223
Autor:
Nipun B. Merchant, Jashodeep Datta, Nagaraj S. Nagathihalli, Sulagna Banerjee, Xi Chen, Yuguang Ban, Zhen Gao, Supriya Srinivasan, Anna Bianchi, Iago De Castro Silva, Siddharth Mehra, Xizi Dai, Samara Singh, Austin R. Dosch
Supplementary Fig. S1-S4 and figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e1a570ae8bc301220e2c85ff1974f7
https://doi.org/10.1158/1535-7163.22522249
https://doi.org/10.1158/1535-7163.22522249
Autor:
Nagaraj S. Nagathihalli, Nipun B. Merchant, Richard Caprioli, Nilesh Kashikar, Deukwoo Kwon, Brent A. Willobee, Supriya Srinivasan, Siddharth Mehra, Michelle L. Reyzer, Xizi Dai, Austin R. Dosch
Weight of PKT mice during treatment regimen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530352650d82714301ee967e44a0fc25
https://doi.org/10.1158/1541-7786.22515231.v1
https://doi.org/10.1158/1541-7786.22515231.v1
Autor:
Nagaraj S. Nagathihalli, Nipun B. Merchant, Michael VanSaun, Nilesh Kashikar, Deukwoo Kwon, Xi Chen, Praveen Kumar Vemula, Jason Castellanos, Shobith Rangappa, Chandrashekhar Joshi, Alexander A. Gaidarski, Austin R. Dosch, Purushottam Lamichhane, Venkatakrishna R. Jala, Supriya Srinivasan, Tulasigeri M. Totiger
Supplementary Figure S6 shows body weight of PKT mice and xenograft mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790f1c5e6bedf8871458220daf4db2f5
https://doi.org/10.1158/1535-7163.22507762.v1
https://doi.org/10.1158/1535-7163.22507762.v1