Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Austin M. Rountree"'
Autor:
Celia M. Bisbach, Daniel T. Hass, Brian M. Robbings, Austin M. Rountree, Martin Sadilek, Ian R. Sweet, James B. Hurley
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: When O2 is plentiful, the mitochondrial electron transport chain uses it as a terminal electron acceptor. However, the mammalian retina thrives in a hypoxic niche in the eye. We find that mitochondria in retinas adapt to their hypoxic enviro
Externí odkaz:
https://doaj.org/article/64842dbbc56043f9a737c66ee85c4247
Autor:
Sean R. Jesinkey, Anila K. Madiraju, Tiago C. Alves, OrLando H. Yarborough, Rebecca L. Cardone, Xiaojian Zhao, Yassmin Parsaei, Ali R. Nasiri, Gina Butrico, Xinran Liu, Anthony J. Molina, Austin M. Rountree, Adam S. Neal, Dane M. Wolf, John Sterpka, William M. Philbrick, Ian R. Sweet, Orian H. Shirihai, Richard G. Kibbey
Publikováno v:
Cell Reports, Vol 28, Iss 3, Pp 759-772.e10 (2019)
Summary: Mechanisms coordinating pancreatic β cell metabolism with insulin secretion are essential for glucose homeostasis. One key mechanism of β cell nutrient sensing uses the mitochondrial GTP (mtGTP) cycle. In this cycle, mtGTP synthesized by s
Externí odkaz:
https://doaj.org/article/be7e1143ef2a432fb03f9abb2af5253d
Autor:
Amit Kumar, Manisha Vaish, Saravanan S Karuppagounder, Irina Gazaryan, John W Cave, Anatoly A Starkov, Elizabeth T Anderson, Sheng Zhang, John T Pinto, Austin M Rountree, Wang Wang, Ian R Sweet, Rajiv R Ratan
Publikováno v:
eLife, Vol 10 (2021)
Hypoxic adaptation mediated by HIF transcription factors requires mitochondria, which have been implicated in regulating HIF1α stability in hypoxia by distinct models that involve consuming oxygen or alternatively converting oxygen into the second m
Externí odkaz:
https://doaj.org/article/5101dfdcd63d48c8a22c4fac2e9e0afc
Autor:
Rajiv R. Ratan, Manisha Vaish, Ian R. Sweet, Anatoly A. Starkov, Amit Kumar, Sheng Zhang, Irina G. Gazaryan, John T. Pinto, Saravanan S. Karuppagounder, John W. Cave, Elizabeth T Anderson, Wang Wang, Austin M. Rountree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1fe54fe978547fbdd344fcc2e8e5f3a
https://doi.org/10.7554/elife.72873.sa2
https://doi.org/10.7554/elife.72873.sa2
Publikováno v:
Islets
The aim of the study was to determine the acute contribution of fuel oxidation in mediating the increase in insulin secretion rate (ISR) in response to fatty acids. Measures of mitochondrial metabolism, as reflected by oxygen consumption rate (OCR) a
Metabolic function in aging retina and retinal pigment epithelium remains robust despite vision loss
Autor:
David J. Marcinek, Jeremy Whitson, Mariya T. Sweetwyne, Celia M. Bisbach, Ian R. Sweet, Whitney M. Cleghorn, Ana P. Valencia, Connor Jankowski, Austin M. Rountree, James B. Hurley, Martin Sadilek, Kristine Tsantilas, Brian M. Robbings, Jonathan D. Linton, Peter S. Rabinovitch, Huiliang Zhang, Campbell, Daniel T. Hass
PurposeCharacterize how metabolic function in the murine retina and retinal pigment epithelium-choroid-sclera (eyecup) complex is impacted by natural aging.MethodsWe examined scotopic and photopic visual function of young (3-6 months) and aged (23-26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93d0e0ac6ee2a02761df0e803ff6cf39
https://doi.org/10.1101/2021.04.06.438698
https://doi.org/10.1101/2021.04.06.438698
Autor:
Irina G. Gazaryan, Austin M. Rountree, Ian R. Sweet, John W. Cave, Elizabeth T Anderson, John T. Pinto, Anatoly A. Starkov, Amit Kumar, Sheng Zhang, Saravanan S. Karuppagounder, Weisheng Wang, Manisha Vaish, Rajiv R. Ratan
Hypoxic adaptation mediated by HIF transcription factors has been shown to require mitochondria. Current models suggest that mitochondria regulate oxygen sensor (HIF prolyl hydroxylase) activity and HIF1α stability during hypoxia by either increasin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5190977daa6926248d6e89ba29e8d479
https://doi.org/10.1101/2020.05.05.079681
https://doi.org/10.1101/2020.05.05.079681
Autor:
Daniel T. Hass, James B. Hurley, Ian R. Sweet, Celia M. Bisbach, Austin M. Rountree, Brian M. Robbings, Martin Sadilek
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp-(2020)
Cell Rep
Cell Rep
When O2 is plentiful, the mitochondrial electron transport chain uses it as a terminal electron acceptor. However, the mammalian retina thrives within a hypoxic niche in the eye. We find that mitochondria in retinas adapt to their hypoxic environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3aaee0bc4398f71345e8b837649076
https://doi.org/10.1101/2020.01.17.909929
https://doi.org/10.1101/2020.01.17.909929
Autor:
Ian R. Sweet, Benjamin J. Reed, Huiliang Zhang, Austin M. Rountree, Adam S. Neal, Kelly Kernan, William R. A. Osborne, Brian Van Yserloo, Wang Wang
Publikováno v:
Biochemical Journal. 473:4443-4456
A real-time method to measure intracellular hydrogen peroxide (H 2 O 2 ) would be very impactful in characterizing rapid changes that occur in physiologic and pathophysiologic states. Current methods do not provide the sensitivity, specificity and sp
Autor:
Craig W. Philips, Daniel L. Cook, Gamal Khalil, Dominic P. Williams, Adam S. Neal, Peter Newham, Ian R. Sweet, Terrance J. Kavanagh, Austin M. Rountree
Publikováno v:
Toxicological Sciences. 148:594-602
There is a general need to detect toxic effects of drugs during preclinical screening. We propose that increased sensitivity of xenobiotics toxicity combined with improved in vitro physiological recapitulation will more accurately assess potentially