Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Austin M, Guo"'
Autor:
Juan A, Azcona, Samantha, Tang, Elizabeth, Berry, Frank F, Zhang, Radha, Garvey, John R, Falck, Michal Laniado, Schwartzman, Tao, Yi, Thomas M, Jeitner, Austin M, Guo
Publikováno v:
J Pharmacol Exp Ther
Compensatory angiogenesis is an important adaptation for recovery from critical ischemia. We recently identified 20-hydroxyeicosatetraenoic acid (20-HETE) as a novel contributor of ischemia-induced angiogenesis. However, the precise mechanisms by whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595794d0963eda57adce6a9d9a0c7639
https://doi.org/10.1124/jpet.121.001036
https://doi.org/10.1124/jpet.121.001036
Autor:
Jing Yang, Honglei Chen, Austin M. Guo, Jing Zhang, Chong Shu, Honglin Tang, Xi Yuan, Lilong Liu, Yu Xiong, Xuewei Chen, Chenlong Wang, Yang Wang, Yanzhuo Liu, Xuehan Chen
Fatty acid synthesis facilitates tumor cell immune escape and immunotherapy resistance. Cytochrome P450 (CYP) 4A and 4F, the major ω-hydroxylases that convert arachidonic acid (AA) into 20-hydroxyeicosatetraenoic acid (20-HETE), are implicated in in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d14bb7139c3d6da7b5ec0f18ead950b
https://doi.org/10.1158/0008-5472.c.6514253.v1
https://doi.org/10.1158/0008-5472.c.6514253.v1
Autor:
Jing Yang, Honglei Chen, Austin M. Guo, Jing Zhang, Chong Shu, Honglin Tang, Xi Yuan, Lilong Liu, Yu Xiong, Xuewei Chen, Chenlong Wang, Yang Wang, Yanzhuo Liu, Xuehan Chen
Supplementary Data from CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non–Small Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec0d68a3597c94265204325a733ffc6
https://doi.org/10.1158/0008-5472.22432832
https://doi.org/10.1158/0008-5472.22432832
Autor:
Li Chen, Austin M. Guo, Xiao-Han Jin, Zi-Hao Feng, Jin-Ling Duan, Jiewei Chen, Mu-Yan Cai, Feng-Wei Wang, Jie Luo, Dan Xie
Publikováno v:
Oncogene. 40:5925-5937
Low levels of ITLN1 have been correlated with obesity-related colorectal carcinogenesis, however, the specific functions and underlying mechanisms remain unclear. Thus, we sought to explore the inhibitory role of ITLN1 in the tumor-permissive microen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c76b7c4f9784a678fa92c19059911d7
https://doi.org/10.1038/s41388-021-01965-5
https://doi.org/10.1038/s41388-021-01965-5
Autor:
Xuehan Chen, Yanzhuo Liu, Yang Wang, Chenlong Wang, Xuewei Chen, Yu Xiong, Lilong Liu, Xi Yuan, Honglin Tang, Chong Shu, Jing Zhang, Austin M. Guo, Honglei Chen, Jing Yang
Publikováno v:
Cancer research. 82(21)
Fatty acid synthesis facilitates tumor cell immune escape and immunotherapy resistance. Cytochrome P450 (CYP) 4A and 4F, the major ω-hydroxylases that convert arachidonic acid (AA) into 20-hydroxyeicosatetraenoic acid (20-HETE), are implicated in in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fd42ff121df789735debe45ab18241
https://pubmed.ncbi.nlm.nih.gov/36321265
https://pubmed.ncbi.nlm.nih.gov/36321265
Autor:
Thaiz Ferraz Borin, Debora A P C Zuccari, Bruna V Jardim-Perassi, Lívia C Ferreira, A S M Iskander, Nadimpalli Ravi S Varma, Adarsh Shankar, Austin M Guo, Guillermo Scicli, Ali S Arbab
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e116247 (2014)
A selective inhibitor of 20-HETE synthesis, HET0016, has been reported to inhibit angiogenesis. 20-HETE has been known as a second mitogenic messenger of angiogenesis inducing growth factors. HET0016 effects were analyzed on MDA-MB-231 derived breast
Externí odkaz:
https://doaj.org/article/0266ef7d2ad343b5be9f4c5917c8426a
Publikováno v:
Circulation. 142
Introduction: Compensatory angiogenic response to ischemia is often insufficient in maintaining adequate tissue perfusion resulting in critical limb ischemia and amputation. Identifying a novel mechanism by which angiogenesis occurs in these conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05efdba813f44081cd6808007bac8306
https://doi.org/10.1161/circ.142.suppl_3.15873
https://doi.org/10.1161/circ.142.suppl_3.15873
Autor:
Raymond C. Koehler, Jian Wang, Xi Liu, John R. Falck, Austin M. Guo, Xiaoning Han, Zeng-Jin Yang, Xiaochun Zhao, Qian Li, Jieru Wan, Yufeng Gao, Weidong Zang, Xi Lan, Xuemei Chen
Publikováno v:
J Cereb Blood Flow Metab
20-HETE, an arachidonic acid metabolite synthesized by cytochrome P450 4A, plays an important role in acute brain damage from ischemic stroke or subarachnoid hemorrhage. We tested the hypothesis that 20-HETE inhibition has a protective effect after i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c1a8d555733b2b28abb0ff52938f23
https://doi.org/10.1177/0271678x18762645
https://doi.org/10.1177/0271678x18762645
Autor:
Branislava Janic, Austin M Guo, A S M Iskander, Nadimpalli Ravi S Varma, Alfonso G Scicli, Ali S Arbab
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9173 (2010)
Stem cells/progenitors are central to the development of cell therapy approaches for vascular ischemic diseases. The crucial step in rescuing tissues from ischemia is improvement of vascularization that can be achieved by promoting neovascularization
Externí odkaz:
https://doaj.org/article/c070b3aaa56b4c80b2d30ddc2d08d605
Autor:
John R. Falck, Austin M. Guo, Victor Garcia, Michal L. Schwartzman, Samantha Tang, Li Chen, Ali S. Arbab, Frank Zhang
Publikováno v:
Am J Physiol Heart Circ Physiol
20-Hydroxyeicosatetraenoic acid (20-HETE) was recently identified as a novel contributor of ischemia-induced neovascularization based on the key observation that pharmacological interferences of CYP4A/20-HETE decrease ischemic neovascularization. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64593829235eeff39df2a72b22065c13
https://europepmc.org/articles/PMC6620690/
https://europepmc.org/articles/PMC6620690/