Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Austin L. Wang"'
Autor:
Jeremy Leitz, Chuchu Wang, Luis Esquivies, Richard A. Pfuetzner, John Jacob Peters, Sergio Couoh-Cardel, Austin L. Wang, Axel T. Brunger
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114026- (2024)
Summary: Synaptic vesicle docking and priming are dynamic processes. At the molecular level, SNAREs (soluble NSF attachment protein receptors), synaptotagmins, and other factors are critical for Ca2+-triggered vesicle exocytosis, while disassembly fa
Externí odkaz:
https://doaj.org/article/e1056b181dfa43a28fe7d62ec5082454
Autor:
Aimee W. Kao, Austin L Wang, Anand Patwardhan, Michael Grabe, Phi T. Nguyen, Kean-Hooi Ang, Anna V. Molofsky, Carolina Alquezar, Michelle R. Arkin, Marcus Y. Chin, Mackenzie Welch
Publikováno v:
ACS Sensors
ACS sensors, vol 6, iss 6
ACS sensors, vol 6, iss 6
Lysosomes are important sites for macromolecular degradation, defined by an acidic lumenal pH of ∼4.5. To better understand lysosomal pH, we designed a novel, genetically encoded, fluorescent protein (FP)-based pH biosensor called Fluorescence Indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2415b35c8d9c812672f8372fce4396ee
https://doi.org/10.1021/acssensors.0c02318
https://doi.org/10.1021/acssensors.0c02318
Autor:
Austin L Wang, Wilian A. Cortopassi, Matthew P. Jacobson, Victoria J. Butler, Aimee W. Kao, Sushmitha Gururaj, Olivia M Pierce
Publikováno v:
Biochemistry
Progranulin (PGRN) is an evolutionarily conserved glycoprotein associated with several disease states, including neurodegeneration, cancer, and autoimmune disorders. This protein has recently been implicated in the regulation of lysosome function, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6024f73ee9e6ad06204ca85f1cc3090
https://doi.org/10.1021/acs.biochem.9b00275
https://doi.org/10.1021/acs.biochem.9b00275
Autor:
Sandra E. Encalada, Biao Li, Edgar Gutierrez, Eva-Maria Mandelkow, Mihir Vohra, David Soriano-Castell, Aimee W. Kao, Frank J.A. Dennissen, Juan A. Oses-Prieto, Austin L Wang, Dominique A. Salazar, Miguel Alves-Ferreira, Sean D. Mooney, Victoria J. Butler, Kaveh Ashrafi, Alma L. Burlingame, Kathy H. Li, Beibei Jing, Alex Groisman
Publikováno v:
Human molecular genetics, vol 28, iss 9
Human Molecular Genetics
Human molecular genetics 28(9), 1498-1514 (2018). doi:10.1093/hmg/ddy442
Human Molecular Genetics
Human molecular genetics 28(9), 1498-1514 (2018). doi:10.1093/hmg/ddy442
Mutations in the microtubule-associated protein tau (MAPT) underlie multiple neurodegenerative disorders, yet the pathophysiological mechanisms are unclear. A novel variant in MAPT resulting in an alanine to threonine substitution at position 152 (A1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2fd562da33ba17969c5f579e917b05
https://escholarship.org/uc/item/18w0z80x
https://escholarship.org/uc/item/18w0z80x
Autor:
Cong Ma, Austin L. Wang, Axel T. Brunger, Xiaofei Yang, Shen Wang, Ucheor B. Choi, Xiaoyu Yang, Yun Li, Jihong Gong
Publikováno v:
The EMBO journal. 36(6)
The soluble N‐ethylmaleimide‐sensitive factor attachment protein receptor (SNARE) protein syntaxin‐1 adopts a closed conformation when bound to Munc18‐1, preventing binding to synaptobrevin‐2 and SNAP‐25 to form the ternary SNARE complex.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0082f82d9adb984873a9c6b9fdf1d8
https://pubmed.ncbi.nlm.nih.gov/28137749
https://pubmed.ncbi.nlm.nih.gov/28137749
Autor:
Austin L. Wang, Jiajie Diao, Axel T. Brunger, Yunxiang Zhang, Ucheor B. Choi, Minglei Zhao, Ying Lai, Richard A. Pfuetzner
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Complexin activates Ca(2+)-triggered neurotransmitter release and regulates spontaneous release in the presynaptic terminal by cooperating with the neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and the Ca(2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01af8a9b2ac71b997982201036edd45
https://doi.org/10.1073/pnas.1604348113
https://doi.org/10.1073/pnas.1604348113
Autor:
Axel T. Brunger, Richard A. Pfuetzner, Jiajie Diao, Tobias Meyer, Arnold Hayer, Ying Lai, Moira A. McMahon, Seth Malmersjö, Austin L. Wang, Serena Di Palma, Bernd Bodenmiller, Matthew H. Porteus
Publikováno v:
EMBO Journal
The EMBO Journal, 35 (16)
The EMBO Journal
The EMBO Journal, 35 (16)
The EMBO Journal
Membrane fusion is essential for eukaryotic life, requiring SNARE proteins to zipper up in an α-helical bundle to pull two membranes together. Here, we show that vesicle fusion can be suppressed by phosphorylation of core conserved residues inside t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c4f10135ce8d51cbaffc7c1ce20eea
Autor:
ChoongKu Lee, Austin L. Wang, Ying Lai, Ucheor B. Choi, Minglei Zhao, Bekir Altas, Nils Brose, Hong Jun Rhee, Jeong-Seop Rhee, Axel T. Brunger, Jeremy Leitz, Richard A. Pfuetzner
Publikováno v:
Neuron. 95:591-607.e10
Summary Munc13 catalyzes the transit of syntaxin from a closed complex with Munc18 into the ternary SNARE complex. Here we report a new function of Munc13, independent of Munc18: it promotes the proper syntaxin/synaptobrevin subconfiguration during a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d31c0365ada953f26c0750270260f3
https://doi.org/10.1016/j.neuron.2017.07.004
https://doi.org/10.1016/j.neuron.2017.07.004
Autor:
Sara M, Wasserman, Jacob W, Aptekar, Patrick, Lu, Jade, Nguyen, Austin L, Wang, Mehmet F, Keles, Anna, Grygoruk, David E, Krantz, Camilla, Larsen, Mark A, Frye
Publikováno v:
Current biology : CB. 25(4)
It is well established that perception is largely multisensory; often served by modalities such as touch, vision, and hearing that detect stimuli emanating from a common point in space; and processed by brain tissue maps that are spatially aligned. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1ef24099b2be2637861764f20f778d4
https://pubmed.ncbi.nlm.nih.gov/25734268
https://pubmed.ncbi.nlm.nih.gov/25734268