Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Austin L. Shug"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1344:201-209
Alteration in energy metabolism of postmenopausal women might be related to the reduction of dehydroepiandrosterone sulfate (DHEAS). DHEA and DHEAS decline with age, leveling at their nadir near menopause. DHEA and DHEAS modulate fatty acid metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6b6f7ce2dae2475c6840de74428fb3
https://doi.org/10.1016/s0005-2760(96)00141-5
https://doi.org/10.1016/s0005-2760(96)00141-5
Autor:
Tom L. Broderick, James Gamble, Dennis J. Paulson, Gary D. Lopaschuk, Denise DiDomenico, Austin L. Shug, George Panagakis
Publikováno v:
Cardiovascular Research. 30:815-820
Objectives: Increasing myocardial camitine content can improve heart function in patients with camitine deficiency. We were interested in determining the effects of l-carnitine on cardiac function and substrate metabolism in a rat model of camitine d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2ae98bbe744a1ac596f81187a5edc9c
https://doi.org/10.1016/s0008-6363(95)00111-5
https://doi.org/10.1016/s0008-6363(95)00111-5
Autor:
Dennis J. Paulson, Bruce A. Wolf, Austin L. Shug, Tom L. Broderick, Denise DiDomenico, Steve C. Christos
Publikováno v:
Metabolism. 44:499-505
Carnitine-deficiency syndromes are often associated with alterations in lipid metabolism and cardiac function. The present study was designed to determine whether this is also seen in an experimental model of carnitine deficiency. Carnitine deficienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f253de9587519be43b25cc69abcfbb
https://doi.org/10.1016/0026-0495(95)90058-6
https://doi.org/10.1016/0026-0495(95)90058-6
Autor:
Austin L. Shug, David C. Madsen
Publikováno v:
The Journal of Nutritional Biochemistry. 5:356-359
This study was conducted to determine the efficacy of amino acids and/or Procysteine (Clintec Technologies, Inc., Deerfield, IL, USA) on the recovery of cardiac function of the rat heart subjected to ischemia/reperfusion. Recovery of myocardium follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6847146e33de291e85c6239f4d40739e
https://doi.org/10.1016/0955-2863(94)90066-3
https://doi.org/10.1016/0955-2863(94)90066-3
Publikováno v:
Life Sciences. 54:567-577
The effects of amino acids in protecting against ischemic/reperfusion injury were tested in two experimental models: the isolated perfused rat heart subjected to 21 min of zero flow ischemia (37 degrees) followed by 40 min of reperfusion and the isol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd3617d00975f2959027c78cd220a9e
https://doi.org/10.1016/0024-3205(94)90008-6
https://doi.org/10.1016/0024-3205(94)90008-6
Publikováno v:
Molecular and Cellular Biochemistry. 116:131-137
Diabetics suffer from an increased incidence of myocardial infarction and are less likely to survive an ischemic insult. Since L-propionylcarnitine (LPC) has been shown to protect against ischemic/reperfusion injury, we hypothesized that LPC may be o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c0e8191b34a5113fd0304ee8a15ed9
https://doi.org/10.1007/bf01270580
https://doi.org/10.1007/bf01270580
Publikováno v:
Cardiovascular Drugs and Therapy. 5:77-83
When cardiac function in isolated rat hearts was impaired by subjecting them to ischemia, subsequent perfusion with propionyl-L-carnitine and related compounds increased their rate of recovery. Thus at 11 mM, both propionyl-L-carnitine and, to a less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9176d1e9301a10c7187f982347fb4e
https://doi.org/10.1007/bf00128246
https://doi.org/10.1007/bf00128246
Autor:
Evan T. Keller, Thomas C. Havighurst, Austin L. Shug, Stefan Gravenstein, Kit Mui Chiu, Raymond A. Daynes, Mary J. Schmidt
Publikováno v:
Age and ageing. 28(2)
Objectives: L-carnitine and dehydro-epiandrosterone (DHEA) independently promote mitochondrial energy metabolism. We therefore wondered if an age-related deficiency of L-carnitine or DHEA may account for the declining energy metabolism associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5a29cbe8c25af5f6519ab630552276
https://pubmed.ncbi.nlm.nih.gov/10350401
https://pubmed.ncbi.nlm.nih.gov/10350401
Autor:
Dennis J. Paulson, Austin L. Shug
Publikováno v:
The Carnitine System ISBN: 9789401041225
There is considerable evidence that L-carnitine and some of its short-chain acyl derivatives (acetyl-L-carnitine, propionyl-L-carnitine and propionylcarnitine taurine amide) are capable of protecting the heart against ischemic/ reperfusion injury. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a36dc6d09e3c931dcf712a519ac34b4f
https://doi.org/10.1007/978-94-011-0275-9_13
https://doi.org/10.1007/978-94-011-0275-9_13
Publikováno v:
Lipid Metabolism in the Healthy and Disease Heart ISBN: 9781461365594
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e62c79ea9a45430a254224e635db654
https://doi.org/10.1007/978-1-4615-3514-0_19
https://doi.org/10.1007/978-1-4615-3514-0_19