Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Austin J. Yang"'
Autor:
Stefani N. Thomas, Zhongping Liao, David Clark, Yangyi Chen, Ramin Samadani, Li Mao, David K. Ann, Janet E. Baulch, Paul Shapiro, Austin J. Yang
Publikováno v:
Proteomes, Vol 1, Iss 2, Pp 87-108 (2013)
Radiation and drug resistance are significant challenges in the treatment of locally advanced, recurrent and metastatic breast cancer that contribute to mortality. Clinically, radiotherapy requires oxygen to generate cytotoxic free radicals that caus
Externí odkaz:
https://doaj.org/article/4e3e1731cea2430d8a1e824f99d75e7e
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 1, Pp 19-31 (2001)
Our previous studies suggest that a failure to degrade aggregated Aβ1-42 in late endosomes or secondary lysosomes is a mechanism that contributes to intracellular accumulation in Alzheimer's disease. In this study, we demonstrate that cultured prima
Externí odkaz:
https://doaj.org/article/7669ede05f334bd986f0282ee5af7a50
Autor:
Yuka A. Martens, Na Zhao, Chia-Chen Liu, Takahisa Kanekiyo, Austin J. Yang, Alison M. Goate, David M. Holtzman, Guojun Bu
Publikováno v:
Neuron
The ε4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for Alzheimer's disease (AD) and several other neurodegenerative conditions, including Lewy body dementia (LBD). The three APOE alleles encode protein isoforms that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2514d8a9f79839b3580dd9639a5f077c
https://doi.org/10.1016/j.neuron.2022.03.004
https://doi.org/10.1016/j.neuron.2022.03.004
Autor:
Songhui Xu, Martin E. Gleave, Arif Hussain, Lingling Fan, David J. Clark, Feyruz V. Rassool, Ladan Fazli, Jianfei Qi, Austin J. Yang, Xiaolu Cui, Fengbo Zhang
Publikováno v:
Cell Death and Disease, Vol 11, Iss 4, Pp 1-16 (2020)
Cell Death & Disease
Cell Death & Disease
The DNA damage response (DDR) pathway is a promising target for anticancer therapies. The androgen receptor and myeloblastosis transcription factors have been reported to regulate expression of an overlapping set of DDR genes in prostate cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5826ebc106d43c187d7c11fe2d98b0b
http://link.springer.com/article/10.1038/s41419-020-2405-4
http://link.springer.com/article/10.1038/s41419-020-2405-4
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107722 (2014)
Radiation induced genomic instability is a well-studied phenomenon, the underlying mechanisms of which are poorly understood. Persistent oxidative stress, mitochondrial dysfunction, elevated cytokine levels and epigenetic changes are among the mechan
Externí odkaz:
https://doaj.org/article/d4f7561e8ebf461b8e769bc23a96fa66
Autor:
Carol J. Huseby, Jean Christophe Cocuron, Grace L. Cooper, Claire N. Hoffman, Stefani N. Thomas, Austin J. Yang, Ana Paula Alonso, Jeff Kuret
Tau is a microtubule-associated protein that normally interacts in monomeric form with the neuronal cytoskeleton. In Alzheimer’s disease, however, it aggregates to form the structural component of neurofibrillary lesions. The transformation is cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0710600a8a0ec8bdf569864dd01f4d7a
https://europepmc.org/articles/PMC6844542/
https://europepmc.org/articles/PMC6844542/
Publikováno v:
Journal of Proteomics. 133:161-169
Exosomes are 30–100 nm sized membrane vesicles released by cells into the extracellular space that mediate intercellular communication via transfer of proteins and other biological molecules. To better understand the role of these microvesicles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0571b84b435edd4ed444b3031ffd8f1d
https://doi.org/10.1016/j.jprot.2015.12.023
https://doi.org/10.1016/j.jprot.2015.12.023
Publikováno v:
Theranostics
Protein glycosylation plays a fundamental role in a multitude of biological processes, and the associated aberrant expression of glycoproteins in cancer has made them attractive biomarkers and therapeutic targets. In this study, we examined different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff7659dce1e5d71b598a53c2e9c56c7
https://doi.org/10.7150/thno.12350
https://doi.org/10.7150/thno.12350
Autor:
David J. Clark, William E. Fondrie, Li Mao, Phyllis I. Hanson, Zhongping Liao, Austin J. Yang, Amy M. Fulton
Publikováno v:
Anal Chem
Exosomes are microvesicles of endocytic origin constitutively released by multiple cell types into the extracellular environment. With evidence that exosomes can be detected in the blood of patients with various malignancies, the development of a pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c770feac0215c5d3cbf42e9303777eb
https://doi.org/10.1021/acs.analchem.5b02586
https://doi.org/10.1021/acs.analchem.5b02586
Autor:
Austin J. Yang, Iris Lindberg, Kevin Z Li, Hong Weng Pang, Joseph P. Stains, Lynda F. Bonewald, David J. Clark
Publikováno v:
Journal of Bone and Mineral Research. 30:449-454
Levels of serum phosphate are controlled by the peptide hormone FGF23, secreted from bone osteocytes. Elevated levels of circulating FGF23 are a key factor in several hypophosphatemic disorders and play a role in chronic kidney disease. Posttranslati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e1166471a36102aa7e2fe7112402188
https://doi.org/10.1002/jbmr.2354
https://doi.org/10.1002/jbmr.2354