Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Austin Hopiavuori"'
Autor:
Tingting Yang, Nancy Ward, Alec Kittredge, Shoudeng Chen, Yu Zhang, Changyi Ji, Yohta Fukuda, Austin Hopiavuori
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Communications Biology
Communications Biology
Mutations of human BEST1, encoding a Ca2+-activated Cl− channel (hBest1), cause macular degenerative disorders. Best1 homolog structures reveal an evolutionarily conserved channel architecture highlighted by two landmark restrictions (named the “
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585170a3e4895274a5806eebd6b3dd01
http://link.springer.com/article/10.1038/s42003-019-0433-3
http://link.springer.com/article/10.1038/s42003-019-0433-3
Autor:
Alec Kittredge, Oliver B. Clarke, Nancy Ward, Aaron P. Owji, Wayne A. Hendrickson, Yu Zhang, Changyi Ji, Austin Hopiavuori, Tingting Yang, Yin Shen, Ziao Fu, Qingqing Zhao
Publikováno v:
Nature structural & molecular biology
The bestrophin family of calcium (Ca2+)-activated chloride (Cl−) channels, which mediate the influx and efflux of monovalent anions in response to the levels of intracellular Ca2+, comprises four members in mammals (bestrophin 1–4). Here we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1604f5d9a781bfc21542f9c33cef0f8e
https://pubmed.ncbi.nlm.nih.gov/32251414
https://pubmed.ncbi.nlm.nih.gov/32251414
Autor:
Alec Kittredge, Yu Zhang, Tingting Yang, Nancy Ward, Peng Yao, Changyi Ji, Yao Li, Austin Hopiavuori, Yohta Fukuda, Stephen H. Tsang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
BEST1 is a Ca2+-activated Cl− channel predominantly expressed in retinal pigment epithelium (RPE), and over 250 genetic mutations in the BEST1 gene have been identified to cause retinal degenerative disorders generally known as bestrophinopathies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e01c10aad0e16451c9d6f2b2f3fd24
https://pubmed.ncbi.nlm.nih.gov/31836750
https://pubmed.ncbi.nlm.nih.gov/31836750
The human genome encodes four bestrophin paralogs, namely BEST1, BEST2, BEST3, and BEST4. BEST1, encoded by the BEST1 gene, is a Ca(2+)-activated Cl(-) channel (CaCC) predominantly expressed in retinal pigment epithelium (RPE). The physiological and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e532dc5b05d0ad3d28c82450156120
https://europepmc.org/articles/PMC6126599/
https://europepmc.org/articles/PMC6126599/
Autor:
Changyi Ji, Austin Hopiavuori, Tingting Yang, Yota Fukuda, Yu Zhang, Shoudeng Chen, Nancy Ward, Alec Kittredge
Publikováno v:
Biophysical Journal. 116:399a-400a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98e17359b059c40cb02221f30d70f720
https://doi.org/10.1016/j.bpj.2018.11.2160
https://doi.org/10.1016/j.bpj.2018.11.2160