Výsledky vyhledávání - "Austin F. Dohrman"

Autor: Adam R. Holmes, Austin F. Dohrman, Dieter C. Gruenert, Aaron R. Ellison, Kaarin K. Goncz

Publikováno v: Pharmaceutical Research. 16:1020-1025

Purpose. The amount and intracellular distribution of DNA fragments (491 -bp) was characterized after transfection in vitro with a commercially available cationic lipid. Localization of fragment to the nucleus, its subcellular distribution, and integ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ba64a5b1909e9f6ce44a5f72bdace3c
https://doi.org/10.1023/a:1018927531003

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Mucin gene (MUC 2 and MUC 5AC) upregulation by Gram-positive and Gram-negative bacteria

Autor: Jay A. Nadel, Susumu Miyata, André Coste, C. Chapelin, Marianne Gallup, Carol Basbaum, Estelle Escudier, Austin F. Dohrman, Jian Dong Li

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1406(3):251-259

Bacterial infection of the lung is associated with mucin overproduction. In partial explanation of this phenomenon, we recently reported that supernatant from the Gram-negative organism Pseudomonas ( P .) aeruginosa contained an activity that upregul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6335805df7de0e220a11685165cf6f44

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Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease

Autor: Austin F. Dohrman, Marianne Gallup, Susumu Miyata, Jay A. Nadel, Alice Prince, Jian Dong Li, James R. Gum, Young S. Kim, Carol Basbaum

Publikováno v: Proceedings of the National Academy of Sciences. 94:967-972

An unresolved question in cystic fibrosis (CF) research is how mutations of the CF transmembrane conductance regulator, a Cl ion channel, cause airway mucus obstruction leading to fatal lung disease. Recent evidence has linked the CF transmembrane co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92d264da72a104c36eaf7b7063dc6ee
https://doi.org/10.1073/pnas.94.3.967

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Upregulation of the 72-kDa Type IV Collagenase in Epithelial and Stromal Cells during Rat Tracheal Gland Morphogenesis

Autor: Austin F. Dohrman, Melissa Lim, Fred Elfman, Gerald R. Cunha, Carol Basbaum

Publikováno v: Developmental Biology. 171:521-530

Submucosal glands secrete most of the mucus that lubricates the tracheal surface and protects it from irritants and infection. These glands develop postnatally in the rat, permitting convenient study of the mechanisms controlling this process. One su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54eac7235cf8bc6e7aa5007824873ca
https://doi.org/10.1006/dbio.1995.1301

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Pseudomonas stimulates interleukin-8 mRNA expression selectively in airway epithelium, in gland ducts, and in recruited neutrophils

Autor: Iris F. Ueki, Austin F. Dohrman, Jeffrey A. Golden, James A. Lausier, Jay A. Nadel, Brendan Chan, Kathleen M. Grattan, Masato Hara, Pierre P. Massion, Hiromasa Inoue

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 11:651-663

Neutrophils may play important roles in chronic airway diseases. Pseudomonas is a common pathogen in some chronic airway diseases, and expression of the neutrophil chemoattractant interleukin-8 (IL-8) is induced by Pseudomonas in various cells in vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3449bbb65ef640d1ac8a3c4a863735a1
https://doi.org/10.1165/ajrcmb.11.6.7946394

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Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer

Autor: Austin F. Dohrman, Young S. Kim, Sae-Kyung Chang, Samuel B. Ho, James R. Gum, Neil W. Toribara, Tohru Tsuda, Carol Basbaum

Publikováno v: Gastroenterology. 107:28-36

Background/Aims: Several studies have reported Northern blot data showing that mucin is expressed in a tissue-specific manner. To determine whether expression is limited to specific cell types within these tissues requires histological analysis. Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d084a82ac63badce5c8b684d1225ad43
https://doi.org/10.1016/0016-5085(94)90057-4

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Molecular cloning of the amino-terminal region of a rat MUC 2 mucin gene homologue. Evidence for expression in both intestine and airway

Autor: Hisamitsu Ohmori, Austin F. Dohrman, Hirofumi Kai, Tohru Tsuda, Marianne Gallup, Young S. Kim, Carol Basbaum, James R. Gum

Publikováno v: Journal of Biological Chemistry. 269:17833-17840

To obtain cDNAs for analysis of mucin gene transcription in rat models of human disease, we screened a rat intestinal cDNA library in lambda ZAPII using an upstream non-tandem repeat cDNA fragment of the human MUC 2 gene (Gum, J., Hicks, J., Toribara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::356017c8164a02e9db0b4ff41923bfc0
https://doi.org/10.1016/s0021-9258(17)32384-0

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Distribution of lysozyme and mucin (MUC2 and MUC3) mRNA in human bronchus

Autor: Young S. Kim, E. Escudier, Tohru Tsuda, Austin F. Dohrman, Berthold Jany, James R. Gum, M. Cardone, Carol Basbaum

Publikováno v: Experimental lung research. 20(4)

Immunocytochemical studies have shown that gel-forming glycoproteins (mucins) and the bacteriolytic protein lysozyme are selectively expressed in airway mucous and serous cells, respectively. The mechanisms mediating this selectivity are unknown. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfd9d11defdab50bb78c28a37c77357
https://pubmed.ncbi.nlm.nih.gov/7988497

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