Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Austin Dulak"'
Autor:
Christopher Wells, Maria Scrivens, Ernest Smith, Michael Warren, Pamela Holland, Andrew Lake, Sonia Das, Vito Palombella, Bijan Etemad-Gilbertson, Austin Dulak
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/ed7f6d75d4c8448fa6d8083af15bf784
Autor:
Garrett W Rhyasen, Yi Yao, Jingwen Zhang, Austin Dulak, Lillian Castriotta, Kelly Jacques, Wei Zhao, Farzin Gharahdaghi, Maureen M Hattersley, Paul D Lyne, Edwin Clark, Michael Zinda, Stephen E Fawell, Gordon B Mills, Huawei Chen
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200826 (2018)
BRD4 is a transcriptional co-activator functioning to recruit regulatory complexes to acetylated chromatin. A subset of High-grade Serous Ovarian Cancer (HGSOC) patients are typified by focal, recurrent BRD4 gene amplifications. Despite previously de
Externí odkaz:
https://doaj.org/article/8462634de4fc494185365ef6a8d1e6ce
Autor:
Michael C. Warren, Stephan Matissek, Matthew Rausch, Marisella Panduro, R. J. Hall, Austin Dulak, David Brennan, Sonia Das Yekkirala, Secil Koseoglu, Ricard Masia, Yu Yang, Navamallika Reddy, Robert Prenovitz, Jamie Strand, Tauqueer Zaidi, Erik Devereaux, Célia Jacoberger Foissac, John Stagg, Benjamin H. Lee, Pamela Holland, Vito J. Palombella, Andrew C. Lake
Publikováno v:
ImmunoHorizons. 7:366-379
CD39 (ENTPD1) is a key enzyme responsible for degradation of extracellular ATP and is upregulated in the tumor microenvironment (TME). Extracellular ATP accumulates in the TME from tissue damage and immunogenic cell death, potentially initiating proi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::730fecc8a4a2e77108479d6425a15698
https://doi.org/10.4049/immunohorizons.2200089
https://doi.org/10.4049/immunohorizons.2200089
Autor:
Huawei Chen, Edwin Clark, Michael Zinda, Michael J. Waring, Stephen E. Fawell, Gordon B. Mills, Paul Lyne, Corinne Reimer, Jonathan R. Dry, Alfred A. Rabow, Tammie C. Yeh, Greg O'Connor, Graeme Walker, Miika J. Ahdesmaki, Larry Bao, Michael Collins, Deborah Lawson, Lillian Castriotta, Shenghua Wen, Jingwen Zhang, Tony Cheung, Scott Boiko, Ian L. Dale, Philip Petteruti, Wenxian Wang, Austin Dulak, Yi Yao, Maureen M. Hattersley, Garrett W. Rhyasen
Supplementary Figure 1. AZD5153 shows reduced BRD4 binding activity when BD2 function is abolished; Supplementary Figure 2. AZD5153 modulates MYC protein levels across hematologic cancer cell lines; Supplementary Figure 3. Gene Ontology (GO) analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a3fc1c9e0ac7cc5baf19a1c1e82cb3
https://doi.org/10.1158/1535-7163.22506301
https://doi.org/10.1158/1535-7163.22506301
Autor:
Huawei Chen, Edwin Clark, Michael Zinda, Michael J. Waring, Stephen E. Fawell, Gordon B. Mills, Paul Lyne, Corinne Reimer, Jonathan R. Dry, Alfred A. Rabow, Tammie C. Yeh, Greg O'Connor, Graeme Walker, Miika J. Ahdesmaki, Larry Bao, Michael Collins, Deborah Lawson, Lillian Castriotta, Shenghua Wen, Jingwen Zhang, Tony Cheung, Scott Boiko, Ian L. Dale, Philip Petteruti, Wenxian Wang, Austin Dulak, Yi Yao, Maureen M. Hattersley, Garrett W. Rhyasen
Protein modulation by AZD5153 in hematological cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95847a4372d50fae63c38140fe63041
https://doi.org/10.1158/1535-7163.22506292.v1
https://doi.org/10.1158/1535-7163.22506292.v1
Autor:
Huawei Chen, Edwin Clark, Michael Zinda, Michael J. Waring, Stephen E. Fawell, Gordon B. Mills, Paul Lyne, Corinne Reimer, Jonathan R. Dry, Alfred A. Rabow, Tammie C. Yeh, Greg O'Connor, Graeme Walker, Miika J. Ahdesmaki, Larry Bao, Michael Collins, Deborah Lawson, Lillian Castriotta, Shenghua Wen, Jingwen Zhang, Tony Cheung, Scott Boiko, Ian L. Dale, Philip Petteruti, Wenxian Wang, Austin Dulak, Yi Yao, Maureen M. Hattersley, Garrett W. Rhyasen
Cell line authentication information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff0443ca83bc32e2d5b91ded374d6cf
https://doi.org/10.1158/1535-7163.22506298.v1
https://doi.org/10.1158/1535-7163.22506298.v1
Autor:
Huawei Chen, Edwin Clark, Michael Zinda, Michael J. Waring, Stephen E. Fawell, Gordon B. Mills, Paul Lyne, Corinne Reimer, Jonathan R. Dry, Alfred A. Rabow, Tammie C. Yeh, Greg O'Connor, Graeme Walker, Miika J. Ahdesmaki, Larry Bao, Michael Collins, Deborah Lawson, Lillian Castriotta, Shenghua Wen, Jingwen Zhang, Tony Cheung, Scott Boiko, Ian L. Dale, Philip Petteruti, Wenxian Wang, Austin Dulak, Yi Yao, Maureen M. Hattersley, Garrett W. Rhyasen
The bromodomain and extraterminal (BET) protein BRD4 regulates gene expression via recruitment of transcriptional regulatory complexes to acetylated chromatin. Pharmacological targeting of BRD4 bromodomains by small molecule inhibitors has proven to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491aac7aed6ce358594bc45ec314c59a
https://doi.org/10.1158/1535-7163.c.6538351.v1
https://doi.org/10.1158/1535-7163.c.6538351.v1
Autor:
Huawei Chen, Edwin Clark, Michael Zinda, Michael J. Waring, Stephen E. Fawell, Gordon B. Mills, Paul Lyne, Corinne Reimer, Jonathan R. Dry, Alfred A. Rabow, Tammie C. Yeh, Greg O'Connor, Graeme Walker, Miika J. Ahdesmaki, Larry Bao, Michael Collins, Deborah Lawson, Lillian Castriotta, Shenghua Wen, Jingwen Zhang, Tony Cheung, Scott Boiko, Ian L. Dale, Philip Petteruti, Wenxian Wang, Austin Dulak, Yi Yao, Maureen M. Hattersley, Garrett W. Rhyasen
Differentially expressed genes with AZD5153 treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1840bcd6939c18a3d1c667350d651fff
https://doi.org/10.1158/1535-7163.22506295
https://doi.org/10.1158/1535-7163.22506295
Autor:
Huawei Chen, J. Carl Barrett, Maureen Hattersley, Austin Dulak, Philip Petteruti, Greg O'Connor, Tammie C. Yeh
Figure S1: Downregulation of CCR2, CD180, MYC and upregulation of HEXIM1 mRNAs by AZD5153 in cells can be detected at 4h; Figure S2: Other BRD4/BET compounds can also downregulate CCR2 and CD180 mRNAs in hematological tumor cell lines; Supplementary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317d92c5b696a9e5ac20538f597c269d
https://doi.org/10.1158/1078-0432.22465697.v1
https://doi.org/10.1158/1078-0432.22465697.v1
Autor:
Jian Yu, Lin Zhang, Zhenghe Wang, John S. Lazo, Robert J. Tomko, Austin Dulak, Hua Li, Xiaodong Zhang, Fangdong Zou, Peng Wang
microRNAs (miRNA) are small noncoding RNAs that participate in diverse biological processes by suppressing target gene expression. Altered expression of miR-21 has been reported in cancer. To gain insights into its potential role in tumorigenesis, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::589d3418881adcc4def388707e96e2c2
https://doi.org/10.1158/0008-5472.c.6500324
https://doi.org/10.1158/0008-5472.c.6500324