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pro vyhledávání: '"Austin C. Wright"'
Autor:
Austin C. Wright, Brian M. Stoltz
Herein we report our recent progress toward the enantioselective total synthesis of the diterpenoid natural products curcusones A–D by means of complementary Stetter annulation or ring-closing metathesis (RCM) disconnections. Using the latter appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c530e9b28c813c70a4b7f0383c46d8bb
https://resolver.caltech.edu/CaltechAUTHORS:20191008-075046379
https://resolver.caltech.edu/CaltechAUTHORS:20191008-075046379
Publikováno v:
Organic letters. 21(23)
We report our iterative efforts toward the divergent total syntheses of curcusones A–D via Suzuki coupling, intramolecular cyclopropanation, and a key divinylcyclopropane rearrangement. Progress of our synthesis was repeatedly challenged by the hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10da0b11f26cbc543b3727b5dd305d8
https://pubmed.ncbi.nlm.nih.gov/31763859
https://pubmed.ncbi.nlm.nih.gov/31763859
Publikováno v:
Organic letters. 21(22)
A versatile thermal Overman rearrangement of enantioenriched, cyclic allylic alcohols providing tertiary allylic amines has been developed. The vinyl bromide used to control enantioselectivity in a preceding CBS reduction is utilized as a synthetic h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d9745b48449960c8d55cca919c22ec
https://pubmed.ncbi.nlm.nih.gov/31663754
https://pubmed.ncbi.nlm.nih.gov/31663754
Autor:
Austin C, Wright, Brian M, Stoltz
Publikováno v:
Chemical Science
Rapid assembly of the carbocyclic core of the curcusone family of natural products is achieved using reductive cross coupling and ring-closing metathesis disconnections.
Herein we report our recent progress toward the enantioselective total synt
Herein we report our recent progress toward the enantioselective total synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55499e4ccdbd008f31308152f393ead8
https://pubmed.ncbi.nlm.nih.gov/32055379
https://pubmed.ncbi.nlm.nih.gov/32055379
Publikováno v:
The Journal of organic chemistry. 84(17)
A modified procedure for dehydrative ketal protections is disclosed, which serves as an alternative to the classic Dean–Stark protocol. Studies show that this new procedure can outperform the Dean–Stark apparatus on small scales and thus serves a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e96fbc25b268f5d5886a9a90f8c2c5
https://pubmed.ncbi.nlm.nih.gov/31403294
https://pubmed.ncbi.nlm.nih.gov/31403294
Autor:
Austin C. Wright, Brian M. Stoltz
Publikováno v:
Organic Syntheses
For the past 50 years, benzynes and related arynes have been a major subject of study among physical organic chemists due to their unusual electronic and structural properties. However, the utility of these strained intermediates in the domain of che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de2a1ac46db1216c3c84eca3a0d5845
https://resolver.caltech.edu/CaltechAUTHORS:20190903-160057854
https://resolver.caltech.edu/CaltechAUTHORS:20190903-160057854
Publikováno v:
Organic Letters. 18:2793-2795
An insertion of arenes into both imides and anhydrides via reactive aryne intermediates is presented. The reaction is performed under exceptionally mild conditions, and the corresponding ketoamide products are amenable to derivatization to deliver a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541f21d3fcdd32090d023623392250c9
https://doi.org/10.1021/acs.orglett.6b00994
https://doi.org/10.1021/acs.orglett.6b00994
Publikováno v:
ChemInform. 47
An insertion of arenes into both imides and anhydrides via reactive aryne intermediates is presented. The reaction is performed under exceptionally mild conditions, and the corresponding ketoamide products are amenable to derivatization to deliver a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17a44f6b89d555848c6e39c84c393b90
https://doi.org/10.1002/chin.201644054
https://doi.org/10.1002/chin.201644054