Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Austin C. Conklin"'
Autor:
Emily F. Merritt, Hannah J. Johnson, Zhee Sheen Wong, Adam S. Buntzman, Austin C. Conklin, Carla M. Cabral, Casey E. Romanoski, Jon P. Boyle, Anita A. Koshy
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT Toxoplasma gondii’s tropism for and persistence in the central nervous system (CNS) underlies the symptomatic disease that T. gondii causes in humans. Our recent work has shown that neurons are the primary CNS cell with which Toxoplasma in
Externí odkaz:
https://doaj.org/article/8ec6668ebe26445abbe5da52c08286cf
Autor:
Maria L Adelus, Jiacheng Ding, Binh T Tran, Austin C Conklin, Anna K Golebiewski, Lindsey K Stolze, Michael B Whalen, Darren A Cusanovich, Casey E Romanoski
Publikováno v:
eLife, Vol 12 (2024)
Heterogeneity in endothelial cell (EC) sub-phenotypes is becoming increasingly appreciated in atherosclerosis progression. Still, studies quantifying EC heterogeneity across whole transcriptomes and epigenomes in both in vitro and in vivo models are
Externí odkaz:
https://doaj.org/article/c8175c955d6e480189b526a1dbd02b29
Autor:
Maria L. Adelus, Jiacheng Ding, Binh T. Tran, Austin C. Conklin, Anna K. Golebiewski, Lindsey K. Stolze, Michael B. Whalen, Darren A. Cusanovich, Casey E. Romanoski
ObjectiveEndothelial cells (ECs) regulate atherogenesis with Endothelial-to-Mesenchymal (EndMT) transition correlating with disease. Single cell (sc) effects of EndMT perturbationsin vitro,with quantitative comparison to signatures of human lesionsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc57dd8371e8b9d190189ce6291c8c2e
https://doi.org/10.1101/2023.04.03.535495
https://doi.org/10.1101/2023.04.03.535495
Autor:
Tiit Örd, Minna U. Kaikkonen, Hitoo Nishi, Casey E. Romanoski, Edward A. Fisher, Kadri Õunap, Austin C. Conklin, Florencia Schlamp
Publikováno v:
Immunometabolism
Background: Vascular smooth muscle cells (VSMC) exhibit phenotypic plasticity in atherosclerotic plaques, and among other approaches, has been modeled in vitro by cholesterol loading. Methods: Meta-analysis of scRNA-seq data from VSMC lineage traced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890f0b3e43a07e56c99a82c268db7e8d
http://europepmc.org/articles/PMC8232871
http://europepmc.org/articles/PMC8232871
Autor:
Shreya Sangam, Yogendra Kanthi, Yinan Shi, Mark W. Geraci, Ayako Makino, Franz Rischard, Jason X.-J. Yuan, Ramon J. Ayon, Casey E. Romanoski, Haiyang Tang, Rebecca Vanderpool, Xinshuai Qi, Austin C. Conklin, Tatum S. Simonson, Aleksandra Babicheva, Manuel L. Gonzalez-Garay, Ankit A. Desai, Robert S. Stearman, Jian Wang, Joe G.N. Garcia
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Pulmonary circulation, vol 10, iss 4
Pulmonary Circulation
Pulmonary circulation, vol 10, iss 4
Pulmonary Circulation
Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e903f5b19e8a06f4c93dec891480627
https://doaj.org/article/e546fc30e21247319e378d3c525325af
https://doaj.org/article/e546fc30e21247319e378d3c525325af
Autor:
Anita A. Koshy, Casey E. Romanoski, Adam Buntzman, Hannah J. Johnson, Emily F. Merritt, Austin C. Conklin, Zhee Sheen Wong, Jon P. Boyle, Carla M. Cabral
Publikováno v:
mSphere
mSphere, Vol 5, Iss 5 (2020)
mSphere, Vol 5, Iss 5 (2020)
Like other persistent intracellular pathogens, Toxoplasma gondii, a protozoan parasite, has evolved to evade the immune system and establish a chronic infection in specific cells and organs, including neurons in the CNS. Understanding T. gondii’s p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99eabf0584626b1f00eb9e368e9c2f29
http://europepmc.org/articles/PMC7471001
http://europepmc.org/articles/PMC7471001
Autor:
Anita A. Koshy, Adam Buntzman, Jon P. Boyle, Casey E. Romanoski, Z. Sheen Wong, Emily F. Merritt, Hannah J. Johnson, Austin C. Conklin, Carla M. Cabral
Toxoplasma gondii’s tropism for and persistence in the CNS underlies the symptomatic disease Toxoplasma causes in humans. Our recent work has shown that neurons are the primary CNS cell with which Toxoplasma interacts and infects in vivo. This pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a8269bee537fdd85fbe09fcc826d3ff
https://doi.org/10.1101/2020.06.09.143099
https://doi.org/10.1101/2020.06.09.143099
Autor:
Christopher S. Hayes, Christopher N. Vassallo, Daniel Wall, Pengbo Cao, Austin C. Conklin, Hayley Finkelstein
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
Myxobacteria are known for complex social behaviors including outer membrane exchange (OME), in which cells exchange large amounts of outer membrane lipids and proteins upon contact. The TraA cell surface receptor selects OME partners based on a vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51658493e3e4dd6443cea6af78596b04
https://elifesciences.org/articles/29397
https://elifesciences.org/articles/29397
Autor:
Christopher N. Vassallo, Daniel Wall, Vera Troselj, Austin C. Conklin, Darshankumar T. Pathak, Arup Dey
Publikováno v:
Journal of bacteriology. 198(6)
Myxobacteria form complex social communities that elicit multicellular behaviors. One such behavior is kin recognition, in which cells identify siblings via their polymorphic TraA cell surface receptor, to transiently fuse outer membranes and exchang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d1b7d867bb1bd39aae642f54cc21e5
https://pubmed.ncbi.nlm.nih.gov/26787762
https://pubmed.ncbi.nlm.nih.gov/26787762
Autor:
Anu Toropainen, Anna Eshghi, Michael B. Whalen, Casey E. Romanoski, Kadri Õunap, Maykel López Rodríguez, Lindsey K. Stolze, Ilakya Selvarajan, Tiit Örd, Minna U. Kaikkonen, Jin Li, Austin C. Conklin, Alice E Solomon, Yun Fang
Publikováno v:
Am J Hum Genet
The American Journal of Human Genetics
The American Journal of Human Genetics
The identification of causal variants and mechanisms underlying complex disease traits in humans is important for the progress of human disease genetics; this requires finding strategies to detect functional regulatory variants in disease-relevant ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76030315e83046d99d09c43d62fa9ce1