A novel pipeline for prioritizing cancer type‐specific therapeutic vulnerabilities using DepMap identifies PAK2 as a target in head and neck squamous cell carcinomas

Autor: Malay K. Sannigrahi, Austin C. Cao, Pavithra Rajagopalan, Lova Sun, Robert M. Brody, Lovely Raghav, Phyllis A. Gimotty, Devraj Basu

Publikováno v: Molecular Oncology, Vol 18, Iss 2, Pp 336-349 (2024)

There is limited guidance on exploiting the genome‐wide loss‐of‐function CRISPR screens in cancer Dependency Map (DepMap) to identify new targets for individual cancer types. This study integrated multiple tools to filter these data in order to

Externí odkaz: https://doaj.org/article/5a52bfb1fc6c4551869e5a8296b1e1e4

Objective screening for olfactory and gustatory dysfunction during the COVID‐19 pandemic: A prospective study in healthcare workers using self‐administered testing

Autor: Austin C. Cao, Zachary M. Nimmo, Natasha Mirza, Noam A. Cohen, Robert M. Brody, Richard L. Doty

Publikováno v: World Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 8, Iss 3, Pp 249-256 (2022)

Abstract Background Smell and taste loss are highly prevalent symptoms in coronavirus disease 2019 (COVID‐19), although few studies have employed objective measures to quantify these symptoms, especially dysgeusia. Reports of unrecognized anosmia i

Externí odkaz: https://doaj.org/article/d915d32b31214854bdfe6520869455fe

Use of the O‐Z flap as an alternative to free tissue transfer for reconstruction of large scalp defects

Autor: Kevin Chorath, Austin C. Cao, Ryan M. Carey, Steven B. Cannady, Mitali Shah, Karthik Rajasekaran, Jason G. Newman, Rabie M. Shanti, Robert M. Brody

Publikováno v: World Journal of Otorhinolaryngology - Head and Neck Surgery. 8:355-360

Objective The reconstruction of large scalp defects poses both functional and cosmetic challenges. While free tissue transfer remains the standard for defects larger than 30 cm2, prolonged anesthesia and postoperative complications remain significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673b75a44600da78fa7e8f520f38e387
https://doi.org/10.1016/j.wjorl.2021.04.006

Cancer type-specific prioritization strategy for targetable dependencies developed from the DepMap profile of head and neck cancer

Autor: Austin C. Cao, Malay K. Sannigrahi, Pavithra Rajagopalan, Robert M. Brody, Lovely Raghav, Phyllis A. Gimotty, Devraj Basu

ObjectivesThe DepMap genome-wide loss of function CRISPR screens offer new insight into gene dependencies in HPV(-) head and neck squamous cell carcinoma (HNSCC) cell lines. We aimed to leverage this data to guide preclinical studies by cataloging no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::754473847e3f903dc07001f10fae1d95
https://doi.org/10.1101/2022.06.12.495566

Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis

Autor: Prasanna Kandel, Fatih Semerci, Rachana Mishra, William Choi, Aleksandar Bajic, Dodge Baluya, LiHua Ma, Kevin Chen, Austin C. Cao, Tipwarin Phongmekhin, Nick Matinyan, Alba Jiménez-Panizo, Srinivas Chamakuri, Idris O. Raji, Lyra Chang, Pablo Fuentes-Prior, Kevin R. MacKenzie, Caroline L. Benn, Eva Estébanez-Perpiñá, Koen Venken, David D. Moore, Damian W. Young, Mirjana Maletic-Savatic

Publikováno v: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 13

Neural stem cells, the source of newborn neurons in the adult hippocampus, are intimately involved in learning and memory, mood, and stress response. Despite considerable progress in understanding the biology of neural stem cells and neurogenesis, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d0473efa092881a5a239cda1bba780
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8498