Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Austin C, Li"'
Publikováno v:
Xenobiotica. 49:302-312
1. Aldehyde oxidase (AO enzymes)-mediated oxidation predominantly occurs at a carbon atom adjacent to the nitrogen on aromatic azaheterocycles. In the current report, we identified that AO enzymes oxidation took place at both the C-2 and C-4 position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfee8a765c52e8b265fd5cdad40ae2d
https://doi.org/10.1080/00498254.2018.1444815
https://doi.org/10.1080/00498254.2018.1444815
Publikováno v:
Rapid Communications in Mass Spectrometry. 28:123-134
Rationale Recent publications have reported that imatinib forms cyanide and methoxylamine adducts in vitro but without detail structural identification. The current work reports the identification of seven cyanide adducts that elucidate the bioactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd88fb5662fc5ee1a4897d38a0807cb1
https://doi.org/10.1002/rcm.6758
https://doi.org/10.1002/rcm.6758
Publikováno v:
Chemical Research in Toxicology. 26:608-615
Medicinal chemists try to avoid certain organic functional groups, summarized in an ever-growing list, in order to avoid the potential bioactivation to reactive metabolites. To add to that alert list, we report herein that boronic acid-containing com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf2dbd55c242135d9eeb544334eb82f
https://doi.org/10.1021/tx400032n
https://doi.org/10.1021/tx400032n
Publikováno v:
Rapid Communications in Mass Spectrometry. 26:906-914
RATIONALE Drug metabolites that have imine or enamine partial structures cause extra mass-to-charge (m/z) increases in online hydrogen/deuterium exchange (HDX) in addition to hydroxyl or amine protons. Online HDX and exact mass measurement were used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af8152053188cfbc891a7ca6d49a77b3
https://doi.org/10.1002/rcm.6178
https://doi.org/10.1002/rcm.6178
Publikováno v:
Rapid Communications in Mass Spectrometry. 23:3003-3012
The relatively high background matrix in in vivo samples typically poses difficulties in drug metabolite identification, and causes repeated analytical runs on unit resolution liquid chromatography/mass spectrometry (LC/MS) systems before the complet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8d990123d07fe39f8ba28ea0b08e6e4
https://doi.org/10.1002/rcm.4207
https://doi.org/10.1002/rcm.4207
Publikováno v:
Rapid Communications in Mass Spectrometry. 23:1742-1745
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa1025d1b027bfb324d88f97fde86010
https://doi.org/10.1002/rcm.4059
https://doi.org/10.1002/rcm.4059
Publikováno v:
Rapid Communications in Mass Spectrometry. 21:4001-4008
This paper describes the complete profiling and characterization of in vitro metabolites of the antidepressant agent nefazodone (NEF) generated by human liver microsome (HLM). Two new metabolic pathways (biotransformation) for NEF have been discovere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8c8a81cca0ea6c67c84786c4da92cb0
https://doi.org/10.1002/rcm.3303
https://doi.org/10.1002/rcm.3303
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 70:1191-1202
The study reported herein examined the metabolism of 14C-labeled hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) resulting from a single oral gavage of 5 ml/kg to male and female Yucatan miniature pigs (43 mg/kg, 56 microCi/kg in 0.5% carboxymethylcell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345ed89c8e9225ba83f295aa7cd93e60
https://doi.org/10.1080/15287390701252717
https://doi.org/10.1080/15287390701252717
Publikováno v:
Rapid Communications in Mass Spectrometry. 21:1421-1430
This paper describes a new strategy that utilizes the fast trap mode scan of the hybrid triple quadrupole linear ion trap (QqQLIT) for the identification of drug metabolites. The strategy uses information-dependent acquisition (IDA) where the enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0177d0be35babdec5bb860bdb51a1b
https://doi.org/10.1002/rcm.2976
https://doi.org/10.1002/rcm.2976
Publikováno v:
Journal of Chromatography B. 825:223-232
In the present work, for the first time, a liquid chromatographic method with tandem mass spectrometric detection (LC-MS/MS) for the simultaneous analysis of norethindrone, and ethinyl estradiol, was developed and validated over the concentration ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d6fe62a75ea6e52e58cf16d33b566a
https://doi.org/10.1016/j.jchromb.2005.01.012
https://doi.org/10.1016/j.jchromb.2005.01.012