Výsledky vyhledávání - "Austin Arrigo"

Abstract 2603: Investigating TUSC2 for its tumor suppressive functions in glioblastoma and its role in gliomagenesis

Autor: Austin Arrigo, Mariana Najjar, Angelina Regua, Hui-Wen Lo

Publikováno v: Cancer Research. 83:2603-2603

The role of Tumor Suppressor Candidate 2 (TUSC2) in glioblastoma (GBM) is still poorly understood. Our recent study (Cancer Letters, 2022) reported, for the first time, that TUSC2 functions as a novel tumor suppressor for GBM. In this report, we foun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d9903cd0387d71465c3578c50b9c2d2
https://doi.org/10.1158/1538-7445.am2023-2603

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Transgenic mouse models of breast cancer

Autor: Hui-Wen Lo, Grace L. Wong, Angelina T. Regua, Austin Arrigo, Daniel Doheny

Publikováno v: Cancer Lett

Transgenic breast cancer mouse models are critical tools for preclinical studies of human breast cancer. Genetic editing of the murine mammary gland allows for modeling of abnormal genetic events frequently found in human breast cancers. Genetically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb59c25746d200d82030ae8dbf2f838
https://doi.org/10.1016/j.canlet.2021.05.027

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Tumor Suppressor Candidate 2 (TUSC2): Discovery, Functions, and Cancer Therapy

Autor: Austin Arrigo, Angelina T. Regua, Mariana K. Najjar, Hui-Wen Lo

Publikováno v: Cancers. 15:2455

Tumor Suppressor Candidate 2 (TUSC2) was first discovered as a potential tumor suppressor gene residing in the frequently deleted 3p21.3 chromosomal region. Since its discovery, TUSC2 has been found to play vital roles in normal immune function, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e67eb379252d3f75df5d21830982245b
https://doi.org/10.3390/cancers15092455

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Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2→CNTF axis to promote progression of brain metastases

Autor: Sherona R. Sirkisoon, Grace L. Wong, Noah R. Aguayo, Daniel L. Doheny, Dongqin Zhu, Angelina T. Regua, Austin Arrigo, Sara G. Manore, Calvin Wagner, Alexandra Thomas, Ravi Singh, Fei Xing, Guangxu Jin, Kounosuke Watabe, Hui-Wen Lo

Publikováno v: Cancer letters. 540

Mechanisms underlying breast cancer brain metastasis (BCBM) are still unclear. In this study, we observed that extracellular vesicles (EVs) secreted from breast cancer cells with increased expression of tGLI1, a BCBM-promoting transcription factor, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ede8d74452917e1ca5af29574889c27
https://pubmed.ncbi.nlm.nih.gov/35589002

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Abstract 92: tGLI1 and IL-6/IL-6R/GP130/STAT3 pathways cooperate to promote breast cancer stem cells and are co-activated in HER2-enriched and triple-negative breast cancers

Autor: Sara G. Manore, Daniel L. Doheny, Dongqin Zhu, Grace L. Wong, Angelina T. Regua, Austin Arrigo, Calvin J. Wagner, Mariana Najjar, Hui-Wen Lo

Publikováno v: Cancer Research. 82:92-92

Breast cancer is the most frequently diagnosed cancer and second leading cause of cancer-related deaths in women; 30% of primary breast cancer cases will develop distant metastases. The majority (90%) of breast cancer-related deaths are due to distan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::123cb1e672e26c326404868fb17f60ec
https://doi.org/10.1158/1538-7445.am2022-92

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Abstract 1039: TrkA and JAK2-STAT3 pathway crosstalk promotes breast cancer stem cells in HER2-enriched and triple-negative breast cancers

Autor: Angelina T. Regua, Dongqin Zhu, Daniel L. Doheny, Grace L. Wong, Sara G. Manore, Calvin J. Wagner, Austin Arrigo, Mariana Najjar, Hui-Wen Lo

Publikováno v: Cancer Research. 82:1039-1039

Breast cancer is the most commonly diagnosed cancer in American women and accounts for ~15% of cancer-related deaths. Despite the current standard of care, metastatic HER2-enriched breast cancer and triple-negative breast cancer remain difficult to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7150630dd9b4df58fc7c38d947f54476
https://doi.org/10.1158/1538-7445.am2022-1039

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Abstract 2354: Astrocytes activated by tGLI1-expressing breast cancer brain metastases upregulate CNTF to activate astrocytes and promote breast cancer stem cells

Autor: Grace L. Wong, Sherona R. Sirkisoon, Noah R. Aguayo, Daniel L. Doheny, Dongqin Zhu, Angelina T. Regua, Austin Arrigo, Sara G. Manore, Calvin J. Wagner, Alexandra Thomas, Ravi Singh, Fei Xing, Guangxu Jin, Kounosuke Watabe, Hui-Wen Lo

Publikováno v: Cancer Research. 82:2354-2354

Breast cancer is the most frequently diagnosed cancer, and second most common source of brain metastasis in women. Despite recent advances in detection and therapeutics, patients with breast cancer brain metastases (BCBM) survive only 6-18 months aft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d5251030f33612c40c066f725443354
https://doi.org/10.1158/1538-7445.am2022-2354

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TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers

Autor: Angelina T. Regua, Grace L. Wong, Austin Arrigo, Sara Abu Jalboush, Jiayuh Lin, Alexandra Thomas, Jimmy Ruiz, Roy E. Strowd, Sara G. Manore, Daniel Doheny, Yang Yu, Noah R. Aguayo, Dongqin Zhu, Calvin J. Wagner, Guangxu Jin, Peiqing Sun, Michael D. Chan, Hui-Wen Lo

Publikováno v: Cancers
Cancers, Vol 13, Iss 2340, p 2340 (2021)
Volume 13
Issue 10

JAK2–STAT3 and TrkA signaling pathways have been separately implicated in aggressive breast cancers
however, whether they are co-activated or undergo functional interaction has not been thoroughly investigated. Herein we report, for the first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca55504ccc6cefa2f5d7909c922d017
https://pubmed.ncbi.nlm.nih.gov/34066153

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Abstract 1979: JAK2/STAT3 and TrkA pathways are frequently co-activated in triple-negative and HER2-enriched breast cancers and the co-activation correlates with an increased potential of metastasis

Publikováno v: Cancer Research. 81:1979-1979

Breast cancer is the leading cause of cancer-related deaths in American women. Despite the current standard-of-care, which implements tumor resection, radiotherapy, and chemotherapy, triple-negative and HER2-positive breast cancer patients often rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91220f54948199f252600e58a404fc07
https://doi.org/10.1158/1538-7445.am2021-1979

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Trk receptor tyrosine kinases in metastasis and cancer therapy

Autor: Angelina T, Regua, Daniel, Doheny, Austin, Arrigo, Hui-Wen, Lo

Publikováno v: Discovery medicine. 28(154)

Tropomyosin receptor kinases (TRKs) were first identified in 1986 when NTRK1 was discovered as part of an oncogenic fusion gene in colorectal cancer and the discovery of NTRK2 and NTRK3 followed shortly after. In the decades since their discovery, TR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a41e35ecf7d485d964097bb4a4aa11f2
https://pubmed.ncbi.nlm.nih.gov/31928627

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