Výsledky vyhledávání - "Austen B, Casey"

A new class of 5‐HT 2A /5‐HT 2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2‐aminotetralins

Autor: Munmun Mukherjee, Ryan P. McGlynn, Meng Cui, Austen B. Casey, Stephen J. Kohut, Raymond G. Booth

Publikováno v: British Journal of Pharmacology. 179:2610-2630

BACKGROUND AND PURPOSE The 5-HT receptor (5-HTR) subtypes 5-HT2A and 5-HT2C are important neurotherapeutic targets, though, obtaining selectivity over 5-HT2B and closely related histamine H1 Rs is challenging. Here, we delineated molecular determinan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2335f8ac5e1c57dad2008077b748e210
https://doi.org/10.1111/bph.15756

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UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice

Autor: Daniel Ryskamp Rijsketic, Austen B. Casey, Daniel A. N. Barbosa, Xue Zhang, Tuuli M. Hietamies, Grecia Ramirez-Ovalle, Matthew B. Pomrenze, Casey H. Halpern, Leanne M. Williams, Robert C. Malenka, Boris D. Heifets

Publikováno v: bioRxiv

The effects of context on the subjective experience of serotonergic psychedelics have not been fully examined in human neuroimaging studies, partly due to limitations of the imaging environment. Here, we administered saline or psilocybin to mice in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbb028a2780211f796c748bbf4f67a4
https://europepmc.org/articles/PMC9980055/

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(S)-5-(2′-Fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder

Autor: Jessica L Armstrong, Munmun Mukherjee, Tanishka S Saraf, Clinton E. Canal, Austen B. Casey, Raymond G. Booth

Publikováno v: ACS Pharmacology & Translational Science. 3:509-523

Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual disabilities and a plethora of neuropsychiatric symptoms. FXS is the leading monogenic cause of autism spectrum disorder (ASD), which is defined clinically by rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29f72af055b9d0e133cde169f99ca41c
https://doi.org/10.1021/acsptsci.9b00101

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'Selective' serotonin 5-HT

Autor: Austen B, Casey, Meng, Cui, Raymond G, Booth, Clinton E, Canal

Publikováno v: Biochem Pharmacol

Blockade of the serotonin 5-HT(2A) G protein-coupled receptor (5-HT(2A)R) is a fundamental pharmacological characteristic of numerous antipsychotic medications, which are FDA-approved to treat schizophrenia, bipolar disorder, and as adjunctive therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e89712418e501d3885e3a78a354c838b
https://pubmed.ncbi.nlm.nih.gov/35381208

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A new class of 5-HT

Autor: Austen B, Casey, Munmun, Mukherjee, Ryan P, McGlynn, Meng, Cui, Stephen J, Kohut, Raymond G, Booth

Publikováno v: British journal of pharmacologyREFERENCES. 179(11)

The 5-HT receptor subtypes 5-HTWe synthesized 42 novel 4-PATs with halogen or aryl moieties at the C(4)-phenyl meta-position. Affinity, function, molecular modeling and 5-HTMost 4-PAT diastereomers in the (2S,4R)-configuration bound non-selectively t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40b844175780894001983064a806ca65
https://pubmed.ncbi.nlm.nih.gov/34837227

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'Selective' serotonin 5-HT2A receptor antagonists

Autor: Austen B. Casey, Meng Cui, Raymond G. Booth, Clinton E. Canal

Publikováno v: Biochemical Pharmacology. 200:115028

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::142aab7cb6517374ad9af43afcecca3c
https://doi.org/10.1016/j.bcp.2022.115028

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Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT

Autor: Charles K, Perry, Austen B, Casey, Daniel E, Felsing, Rajender, Vemula, Mehreen, Zaka, Noah B, Herrington, Meng, Cui, Glen E, Kellogg, Clinton E, Canal, Raymond G, Booth

Publikováno v: Bioorganicmedicinal chemistry. 28(3)

The serotonin 5-HT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1e5345e0438fe2f41e5bdc69b8d4543
https://pubmed.ncbi.nlm.nih.gov/31882369

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Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT1A and 5-HT7 G protein-coupled receptor affinity, 3D-QSAR and molecular modeling

Autor: Raymond G. Booth, Mehreen Zaka, Charles K. Perry, Daniel E. Felsing, Glen E. Kellogg, Meng Cui, Noah B. Herrington, Rajender Vemula, Clinton E. Canal, Austen B. Casey

Publikováno v: Bioorganic & Medicinal Chemistry. 28:115262

The serotonin 5-HT7 G protein-coupled receptor (GPCR) is a proposed pharmacotherapeutic target for a variety of central and peripheral indications, albeit, there are no approved drugs selective for binding 5-HT7. We previously reported that a lead an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23f14acd52f9611f26364f7fb8193bd0
https://doi.org/10.1016/j.bmc.2019.115262

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Classics in Chemical Neuroscience: Aripiprazole

Autor: Austen B. Casey, Clinton E. Canal

Publikováno v: ACS chemical neuroscience. 8(6)

Aripiprazole was the first antipsychotic developed to possess agonist properties at dopamine D2 autoreceptors, a groundbreaking strategy that presented a new vista for schizophrenia drug discovery. The dopamine D2 receptor is the crucial target of al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98066e0c5b32fb6bd475c354c35d780f
https://pubmed.ncbi.nlm.nih.gov/28368577

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