Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells.

Autor: Zwergel C; Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy., Schnekenburger M; Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9 rue Edward Steichen, L-2540, Luxembourg City, Luxembourg., Sarno F; Department of Medicine of Precision, University of Studi della Campania Luigi Vanvitelli, Vico L. De Crecchio 7, 80138, Naples, Italy., Battistelli C; Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy., Manara MC; Laboratory of Experimental Oncology, IRCCS - Istituto Ortopedico Rizzoli, via di Barbiano, 1/10, Bologna, 40136, Italy., Stazi G; Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy., Mazzone R; Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy., Fioravanti R; Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy., Gros C; Center for High-Throughput Chemical Biology, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada., Ausseil F; Pierre Fabre Laboratories, 3 Avenue Hubert Curien, Toulouse, 31100, France., Florean C; Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9 rue Edward Steichen, L-2540, Luxembourg City, Luxembourg., Nebbioso A; Department of Medicine of Precision, University of Studi della Campania Luigi Vanvitelli, Vico L. De Crecchio 7, 80138, Naples, Italy., Strippoli R; Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.; National Institute for Infectious Diseases L. Spallanzani, IRCCS, Via Portuense, 292, Rome, 00149, Italy., Ushijima T; Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan., Scotlandi K; Laboratory of Experimental Oncology, IRCCS - Istituto Ortopedico Rizzoli, via di Barbiano, 1/10, Bologna, 40136, Italy., Tripodi M; Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.; National Institute for Infectious Diseases L. Spallanzani, IRCCS, Via Portuense, 292, Rome, 00149, Italy.; Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy., Arimondo PB; Epigenetic Chemical Biology, Institut Pasteur, CNRS UMR3523, 28 rue du Docteur Roux, Paris, 75724, France., Altucci L; Department of Medicine of Precision, University of Studi della Campania Luigi Vanvitelli, Vico L. De Crecchio 7, 80138, Naples, Italy., Diederich M; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, 08826, Korea., Mai A; Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy. antonello.mai@uniroma1.it.; Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy. antonello.mai@uniroma1.it., Valente S; Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy. sergio.valente@uniroma1.it.

Publikováno v: Clinical epigenetics [Clin Epigenetics] 2019 May 06; Vol. 11 (1), pp. 68. Date of Electronic Publication: 2019 May 06.

Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta

Autor: Boudsocq, F, Benaim, P, Canitrot, Y, Knibiehler, M, Ausseil, F, Capp, J P, Bieth, A, Long, C, David, B, Shevelev, I, Frierich-Heinecken, E, Hübscher, U, Amalric, F, Massiot, G, Hoffmann, J S, Cazaux, C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______885::3fb81946bbf565bc26907322557195b1
https://doi.org/10.5167/uzh-793

EFFICACY OF FUMIGANT COMPOUNDS FROM ESSENTIAL OIL OF FEVERFEW (CHRYSANTHEMUM parthenium L.) AGAINST MAIZE WEEVIL (SITOPHILUS zeamais MOTS.): FUMIGANT TOXICITY TEST AND IN-SILICO STUDY.

Autor: Tessema, Fekade Beshah^1,2, Belachew, Aweke Mulu², Gonfa, Yilma Hunde^2,3, Asfaw, Tilahun Belayneh^2,4, Admassie, Zelalem Gizachew⁵, Bachheti, Archana⁶, Bachheti, Rakesh Kumar^2,7, Tadesse, Mesfin Getachew^2,8 mesfin.getachew@aastu.edu.et

Publikováno v: Bulletin of the Chemical Society of Ethiopia. 2024, Vol. 38 Issue 2, p457-472. 16p.

TTLL12 has a potential oncogenic activity, suppression of ligation of nitrotyrosine to the C-terminus of detyrosinated α-tubulin, that can be overcome by molecules identified by screening a compound library.

Autor: Deshpande, Amit¹ (AUTHOR), Brants, Jan¹ (AUTHOR), Wasylyk, Christine¹ (AUTHOR), van Hooij, Onno² (AUTHOR), Verhaegh, Gerald W.² (AUTHOR), Maas, Peter³ (AUTHOR), Schalken, Jack A.² (AUTHOR), Wasylyk, Bohdan¹ (AUTHOR) boh@igbmc.fr

Publikováno v: PLoS ONE. 2/23/2024, Vol. 19 Issue 2, p1-21. 21p.

Computational drug discovery on human immunodeficiency virus with a customized long short‐term memory variational autoencoder deep‐learning architecture.

Autor: Kutsal, Mucahit¹ (AUTHOR), Ucar, Ferhat² (AUTHOR) fucar@firat.edu.tr, Kati, Nida³ (AUTHOR)

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology. Feb2024, Vol. 13 Issue 2, p308-316. 9p.