Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

Autor: Romain Cayrol, Diana Matheoud, Samantha Gruenheid, Marie-Josée Bourque, Annie Laplante, Michel Desjardins, Lei Zhu, Heidi M. McBride, Charles Ducrot, Anna-Maija Penttinen, Lauriane Ramet, Aurore Voisin, Ahmed M. Fahmy, Armelle Le Campion, Tyler Cannon, Louis-Eric Trudeau

Publikováno v: Nature. 571:565-569

Parkinson’s disease is a neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons in the substantia nigra compacta. Although the mechanisms that trigger the loss of dopaminergic neurons are unclear, mitochondrial dy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de7db0a45e637ace367c415ab03c4606
https://doi.org/10.1038/s41586-019-1405-y

Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

Autor: Ulrik Gether, Freja Herborg, Madhu B. Anand-Srivastava, Nicolas Giguère, Bruno Giros, Aurore Voisin, Louis-Eric Trudeau, Yuan Li, Benoît Delignat-Lavaud, Vincent Jacquemet

Publikováno v: Giguère, N, Delignat-Lavaud, B, Herborg, F, Voisin, A, Li, Y, Jacquemet, V, Anand-Srivastava, M, Gether, U, Giros, B & Trudeau, L-E 2019, ' Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout ', PLOS Genetics, vol. 15, no. 8, e1008352 . https://doi.org/10.1371/journal.pgen.1008352
PLoS Genetics, Vol 15, Iss 8, p e1008352 (2019)
PLoS Genetics

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Rare genetic mutations in genes such as Parkin, Pink1, DJ-1, α-synuclein, LRRK2 and GBA are fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fea1ecefe45f4fe30dd05c636ce7b6d
https://doi.org/10.1371/journal.pgen.1008352