G-quadruplex structure of the C. elegans telomeric repeat: a two tetrads basket type conformation stabilized by a non-canonical C–T base-pair

Autor: Julien Marquevielle, Aurore De Rache, Brune Vialet, Estelle Morvan, Jean-Louis Mergny, Samir Amrane

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2022, 50 (12), pp.7134-7146. ⟨10.1093/nar/gkac523⟩

The Caenorhabditis elegans model has greatly contributed to the understanding of the role of G-quadruplexes in genomic instability. The GGCTTA repeats of the C. elegans telomeres resemble the GGGTTA repeats of the human telomeres. However, the compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89abc6193b6b28965711e28e25f0d668
https://www.hal.inserm.fr/inserm-03807354/document

G-Quadruplex binding optimization by gold( iii ) insertion into the center of a porphyrin

Autor: Geneviève Pratviel, Jean-Luc Stigliani, Emmanuelle Mothes-Martin, Patrick Calsou, Aurore De Rache, Jean-Louis Mergny, Samir Amrane, Coralie Modeste, Dennis Gomez, Angélique Pipier

Publikováno v: Dalton Transactions
Dalton Transactions, Royal Society of Chemistry, 2019, 48 (18), pp.6091-6099. ⟨10.1039/C8DT04703K⟩
Dalton Transactions, Royal Society of Chemistry, 2019, 48 (18), pp.6091-6099. ⟨10.1039/c8dt04703k⟩
Dalton Transactions, 2019, 48 (18), pp.6091-6099. ⟨10.1039/C8DT04703K⟩

International audience; Porphyrins represent a valuable class of ligands for G-quadruplex nucleic acids. Herein, we evaluate the binding of cationic porphyrins metallated with gold(iii) to G-quadruplex DNA and we compare it with other porphyrin deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0a04fb9a75b8bbfb0b6466d55ada25
https://hal.archives-ouvertes.fr/hal-02140554/document

Cobalt(iii)porphyrin to target G-quadruplex DNA

Autor: Enora Prado, Jérôme Dejeu, Chi-Fon Chang, Antonio Garofalo, Pei-Ju Fang, Jean-Louis Mergny, Aurore De Rache, Laurent Sabater, Eric Defrancq, Jung-Hsin Lin, Geneviève Pratviel

Publikováno v: Dalton Transactions
Dalton Transactions, Royal Society of Chemistry, 2015, 44 (8), pp.3701-3707. ⟨10.1039/c4dt03631j⟩

International audience; G-quadruplex DNA ligands attract much attention because of their potential use in biology. Indeed they may interfere with G-quadrulex nucleic acid function in cells. Most of the G-quadruplex ligands so far reported (including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191a69c355f3010667c2366d7038de9d
https://doi.org/10.1039/c4dt03631j

Optimization of the Probe Coverage in DNA Biosensors by a One-Step Coadsorption Procedure

Autor: Aurore De Rache, Claudine Buess-Herman, Anne Meunier, Marc Steichen, Thomas Doneux, Eleonore Triffaux

Publikováno v: ChemElectroChem. 1:147-157

The analytical performances (selectivity, sensitivity, limit-of-detection) are ultimately connected to the interfacial architecture of the sensing surface which needs to be optimised. Self-assembly of a mixed monolayer of thiolated probes and diluent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::745574c7ccaa015d7dffa179b3073e95
https://doi.org/10.1002/celc.201300145

The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells

Autor: Enora Prado, Joris Lacroix, Marie-Laure Nicolau-Travers, Oriane Bombarde, Aurore De Rache, Jean-Louis Mergny, Laurent Sabater, Dennis Gomez, Eric Defrancq, Patrick Calsou, Geneviève Pratviel, Jérôme Dejeu

Publikováno v: Journal of Biological Inorganic Chemistry
Journal of Biological Inorganic Chemistry, Springer Verlag, 2015, 20 (4), pp.729-738. ⟨10.1007/s00775-015-1260-8⟩
Journal of Biological Inorganic Chemistry, 2015, 20 (4), pp.729-738. ⟨10.1007/s00775-015-1260-8⟩

With the aim of finding selective and biologically active G-quadruplex ligands, modified porphyrin with bulky cationic substituents, meso-5,10,15,20-tetrakis(4-guanidinophenyl)porphyrin tetrahydrochloride, referred to as guanidinium phenyl porphyrin,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7119d9751dfe8a366ea75e343e05797
https://hal.archives-ouvertes.fr/hal-03082729