Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Aurore, Varela"'
Autor:
Vincent A. Stadelmann, Gabrielle Boyd, Martin Guillot, Jean-Guy Bienvenu, Charles Glaus, Aurore Varela
Publikováno v:
International Journal of Biomedical Imaging, Vol 2021 (2021)
Objective. While microCT evaluation of atherosclerotic lesions in mice has been formally validated, existing image processing methods remain undisclosed. We aimed to develop and validate a reproducible image processing workflow based on phosphotungst
Externí odkaz:
https://doaj.org/article/de3c6ee816b44f3bbfc576a3d40cfb50
Autor:
LaRonda Morford, Ronee Baracani, Aurore Varela, Arun Tatiparthi, Mukesh Summan, Maralee McVean, Kathleen A. Funk
Publikováno v:
International Journal of Toxicology. 42:182-197
Recommendations on study designs that adequately evaluate the in-life effects leading to juvenile bone toxicity, the various imaging modalities that can aid interpretation of the bone effects, biomarkers that may be useful, and regulatory issues were
Publikováno v:
Toxicologic Pathology. 49:1393-1404
The Society of Toxicologic Pathology’s Annual Virtual Symposium (2021) included a session on "Regulatory Perspectives on Juvenile Animal Toxicologic Pathology." The following narrative summarizes the key concepts from the four talks included in thi
Autor:
Jeffrey L. Brown, Aurore Varela, Bruce H. Mitlak, Marilyne Boyer, Paul J. Kostenuik, Allen Pierce, Martin Guillot, Beate Lanske, Heidi Chandler, Gary Hattersley, Roland Baron, Michael S. Ominsky
Publikováno v:
Bone. 120:148-155
Male osteoporosis can occur with advanced age and with hypogonadism, with increased bone resorption and/or inadequate bone formation contributing to reduced bone mass and increased fracture risk. Abaloparatide is a selective PTH receptor agonist that
Autor:
Alison Wolfreys, Marina Stolina, Aimee M. Deaton, Sheetal V. Kumar, Jun Yin, Gabrielle Boyd, James R. Turk, Charles Glaus, Emily M. de Koning, Lucas D. Ward, Aurore Varela, Yusheng Qu, Gill Holdsworth, Jean-Guy Bienvenu, Yudong D. He, Martin Guillot, Melanie Felx, Denise Dwyer, Michael J. Engwall, Rogely W. Boyce, Kathrin Locher
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 115
Romosozumab (EVENITY™ [romosozumab-aqqg in the US]) is a humanized monoclonal antibody that inhibits sclerostin and has been approved in several countries for the treatment of osteoporosis in postmenopausal women at high risk of fracture. Sclerosti
Autor:
Solomon Haile, Susan Y. Smith, Robert E. Guldberg, Gary Hattersley, Michael S. Ominsky, Aurore Varela, Nancy Doyle, Paul J. Kostenuik
Publikováno v:
Osteoporosis International
Summary Abaloparatide, a novel PTH1 receptor agonist, increased bone formation in osteopenic ovariectomized cynomolgus monkeys while increasing cortical and trabecular bone mass. Abaloparatide increased bone strength and maintained or enhanced bone m
Autor:
Paul J. Kostenuik, Robert E. Guldberg, Aurore Varela, Elisabeth Lesage, Susan Y. Smith, Luc Chouinard, Gary Hattersley
Publikováno v:
Bone. 95:143-150
Abaloparatide is a novel 34 amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor 1 (PTHR1) signaling pathway. The effects of 12months of abaloparatide treatment on bone mass, bone strength and bone qu
Autor:
Nacera Mellal, Rogely W. Boyce, Kathrin Locher, Steven K. Boyd, Melanie Felx, Jacquelin Jolette, Nancy Doyle, Michael S. Ominsky, Sabina Buntich, Aurore Varela, Susan Y. Smith, Ian Pyrah
Publikováno v:
Journal of Bone and Mineral Research. 32:788-801
Romosozumab (Romo), a humanized sclerostin antibody, is a bone-forming agent under development for treatment of osteoporosis. To examine the effects of Romo on bone quality, mature cynomolgus monkeys (cynos) were treated 4 months post- ovariectomy (O
Publikováno v:
Journal of Bone and Mineral Research. 32:24-33
Abaloparatide is a novel 34-amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor (PTH1R) signaling pathway with 41% homology to PTH(1-34) and 76% homology to PTHrP(1-34). A 12-month treatment study wa
Publikováno v:
Toxicologic Pathology for Non-Pathologists ISBN: 9781493997763
The musculoskeletal system provides vital functions such as protection of fragile tissues, support, contribution to mineral homeostasis, and locomotion. In this chapter, we cover toxicologic pathology of importance to the nonpathologist in three majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1460c7c9106bee454547774736c9c652
https://doi.org/10.1007/978-1-4939-9777-0_14
https://doi.org/10.1007/978-1-4939-9777-0_14