Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aurore, Sors"'
Autor:
Hugues Chabriat, Claudio L. Bassetti, Ute Marx, Françoise Picarel-Blanchot, Aurore Sors, Celine Gruget, Barbara Saba, Marine Wattez, Marie-Laure Audoli, Dirk M. Hermann
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-7 (2020)
Abstract Background The GABAA-α5 receptor antagonist S44819 is a promising candidate to enhance functional recovery after acute ischemic stroke (IS). S44819 is currently evaluated in this indication; RESTORE brain study started in Dec 2016 and was c
Externí odkaz:
https://doaj.org/article/d4fef49d73f649789a8ca02b12e09ddc
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 9, Pp 1517-1518 (2019)
Externí odkaz:
https://doaj.org/article/9e3bd4eb75054f30ab783ed44c0a12b1
Autor:
William N. Charman, Aurore Sors, Elisabeth Mocaer, Roger J. Summers, David M. Shackleford, Arthur Christopoulos, Tracie L. Pierce, Christopher J. Langmead, Darren Riddy, Clotilde Mannoury la Cour, Patrick M. Sexton, Anna E. Cook
Publikováno v:
Neuropharmacology. 144:244-255
The histamine H3 receptor is a G protein-coupled receptor (GPCR) drug target that is highly expressed in the CNS, where it acts as both an auto- and hetero-receptor to regulate neurotransmission. As such, it has been considered as a relevant target i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1932d9397d85f972ba49cd524b61df3
https://doi.org/10.1016/j.neuropharm.2018.10.028
https://doi.org/10.1016/j.neuropharm.2018.10.028
Autor:
Peter D. Schellinger, Agnes Koves, Usman A. Khan, Didier Smadja, Gabriel Rodriguez Freitas, Ralf Lindert, Bill O'brien, Jaime Masjuan Vallejo, Aida Lago Martin, Cesar Minelli, Hassan Hosseini, Marine Wattez, Martin Grond, Claudio L. Bassetti, Konrad Rejdak, Marie-Laure Audoli-Inthavong, Luisa Rover, Pere Cardona, Kenneth Butcher, Gabriel R. de Freitas, Gyula Panczel, Tomas Segura Martin, Marianna Gottschal, Maurício André Gheller Friedrich, Hugues Chabriat, Alvaro Ximenez Carrillo, Laura Dorado, Jean-Philippe Neau, Joerg Berrouschot, D. G. Nabavi, Carla H.C. Moro, Nina De Klippel, Norbert Szegedi, Tomasz Berkowicz, Jesse Dawson, Andras Folyovich, Christian Denier, Jean-Louis Mas, Klaus Gröschel, Amit K Mistri, Thanh G. Phan, Timothy Kleinig, Aurore Sors, Dirk M. Hermann, Louise Shaw, Christine Roffe, Nikola Sprigg, Man Seok Park, Hans-Christoph Diener, Hassan Soda, Maite Martinez Zabaleta, Pietro Bassi, Luiz Carlos Porcello Marrone, Dylan Blacquiere, László Vécsei, Stephen N. Davis, Giuseppe Lembo, Rohan Grimley, Charlotte Cordonnier, Geert Vanhooren, Bernd Kallmuenzer, Peter Dioszeghy, Mikael Mazighi, Waldemar Brola, Francisco Moniche Alvarez, Yangha Hwang, Attila Valikovics, Waldemar Fryze, Philippe Desfontaines, Jaume Roquer Gonzalez, David Cohen, Zbigniew Bak, Csaba Ovary, Jae-Kwan Cha, Gisele Sampaio Silva, Carlos A. Molina, Rodrigo Bazan, Hee-Joon Bae, Rubens José Gagliardi, Geoffrey Cloud, Anna Członkowska, Attila Csanyi, Leonardo Barbarini, Sergi Amaro, Jong Sung Kim, Daniel Bereczki, Katharina Althaus, Robin Lemmens, Anetta Lasek-Bal, Theodore Wein, Piotr Sobolewski, Diederik Willem Dippel, Danilo Toni, Laszlo Szapary, Suzanne Ragab, Andrew Wong, Ute Marx, Estelle Lambert, Igor Sibon, Wim M. Mulleners, Ondrej Skoda, Maciej Swiat
Summary Background S44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of the peri-infarct cortex. S44819 improved stroke recovery in rodents and increased cortical excitability in a transcranial magnetic stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b691f063532bca5bfdd45c9b4f2ad883
https://iris.uniroma1.it/handle/11573/1474965
https://iris.uniroma1.it/handle/11573/1474965
Autor:
Aurore Sors, Ute Marx, Claudio L. Bassetti, Hugues Chabriat, F. Picarel-Blanchot, Dirk M. Hermann, Marine Wattez, Marie-Laure Audoli, Barbara Saba, Celine Gruget
Publikováno v:
Trials
Trials, Vol 21, Iss 1, Pp 1-7 (2020)
Chabriat, Hugues; Bassetti, Claudio L.; Marx, Ute; Picarel-Blanchot, Françoise; Sors, Aurore; Gruget, Celine; Saba, Barbara; Wattez, Marine; Audoli, Marie-Laure; Hermann, Dirk M. (2020). Randomized Efficacy and Safety Trial with Oral S 44819 after Recent ischemic cerebral Event (RESTORE BRAIN study): a placebo controlled phase II study. Trials, 21(1), p. 136. BioMed Central 10.1186/s13063-020-4072-2
Trials, Vol 21, Iss 1, Pp 1-7 (2020)
Chabriat, Hugues; Bassetti, Claudio L.; Marx, Ute; Picarel-Blanchot, Françoise; Sors, Aurore; Gruget, Celine; Saba, Barbara; Wattez, Marine; Audoli, Marie-Laure; Hermann, Dirk M. (2020). Randomized Efficacy and Safety Trial with Oral S 44819 after Recent ischemic cerebral Event (RESTORE BRAIN study): a placebo controlled phase II study. Trials, 21(1), p. 136. BioMed Central 10.1186/s13063-020-4072-2
Background The GABAA-α5 receptor antagonist S44819 is a promising candidate to enhance functional recovery after acute ischemic stroke (IS). S44819 is currently evaluated in this indication; RESTORE brain study started in Dec 2016 and was completed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeeab23d617412ae568ee9f511cc7cb1
Autor:
Jean-Marie Delbos, Esther Steidl, Tuulia Huhtala, Aurore Sors, Jean-Michel Arrang, Bruno Buisson, Patrick Casara, Outi Kontkanen, Lionel Bert, Valérie Audinot, Pierre Lestage, Olivier Nosjean, Anne-Marie Chollet, Fany Panayi, Dominique Favale
Publikováno v:
European Journal of Pharmacology. 803:11-23
Histaminergic H3 inverse agonists, by stimulating central histamine release, represent attractive drug candidates to treat cognitive disorders. The present studies aimed to describe the mechanistic profile of S 38093 a novel H3 receptors inverse agon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e956afc9c4cbf151304775e3b54917d
https://doi.org/10.1016/j.ejphar.2017.03.013
https://doi.org/10.1016/j.ejphar.2017.03.013
Autor:
Hugues, Chabriat, Claudio L, Bassetti, Ute, Marx, Marie-Laure, Audoli-Inthavong, Aurore, Sors, Estelle, Lambert, Marine, Wattez, Dirk M, Hermann, Alvaro, Ximenez Carrillo
Publikováno v:
The Lancet. Neurology. 19(3)
S44819, a selective GABARESTORE BRAIN was an international, randomised, double-blind, parallel-group, placebo-controlled, multicentre phase 2 trial that evaluated the safety and efficacy of oral S44189 in patients with recent ischaemic stroke. The st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f6b459913723771892d0162db5d9823
https://pubmed.ncbi.nlm.nih.gov/32333891
https://pubmed.ncbi.nlm.nih.gov/32333891
Autor:
Darren M, Riddy, Anna E, Cook, David M, Shackleford, Tracie L, Pierce, Elisabeth, Mocaer, Clotilde, Mannoury la Cour, Aurore, Sors, William N, Charman, Roger J, Summers, Patrick M, Sexton, Arthur, Christopoulos, Christopher J, Langmead
Publikováno v:
Neuropharmacology. 144
The histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e94add9aac8ddd3ecd01b903421d807
https://pubmed.ncbi.nlm.nih.gov/30359639
https://pubmed.ncbi.nlm.nih.gov/30359639
Autor:
Elisabeth Mocaer, Benjamin Adam Samuels, Alain M. Gardier, Alice Hu, Maryam Mekiri, Marjorie R Levinstein, René Hen, Aurore Sors, Charlène Faye, Jean-Philippe Guilloux, Denis J. David, Indira Mendez-David
Publikováno v:
Scientific Reports
Strategies designed to increase adult hippocampal neurogenesis (AHN) may have therapeutic potential for reversing memory impairments. H3 receptor antagonists/inverse agonists also may be useful for treating cognitive deficits. However, it remains unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623b070a7be0bf50479440d1b4c4f959
Autor:
Gaelle Dominguez, Elisabeth Mocaer, Nadia Henkous, Takashi Yoshitake, Jan Kehr, Aurore Sors, Claire Letondor, Daniel Béracochéa, Ali Krazem
Publikováno v:
Frontiers in Pharmacology. 7
Donepezil, an acetylcholinesterase inhibitor, induces only moderate symptomatic effects on memory in Alzheimer’s disease patients. An alternative strategy for treatment of cognitive symptoms could be to act simultaneously on both histaminergic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc260984cf1e05c788f4d3337a7a19b8