The Aurora-A/TPX2 Axis Directs Spindle Orientation in Adherent Human Cells by Regulating NuMA and Microtubule Stability

Autor: Francesco D. Naso, Italia Anna Asteriti, Giulia Guarguaglini, Alessandro Rosa, Davide Valente, Valentina Palmerini, Marina Mapelli, Divya Singh, Alexander W. Bird, Federica Polverino

Publikováno v: Current biology 31 (2021): 658–667.e5. doi:10.1016/j.cub.2020.10.096
info:cnr-pdr/source/autori:Polverino F.; Naso F.D.; Asteriti I.A.; Palmerini V.; Singh D.; Valente D.; Bird A.W.; Rosa A.; Mapelli M.; Guarguaglini G./titolo:The Aurora-A%2FTPX2 Axis Directs Spindle Orientation in Adherent Human Cells by Regulating NuMA and Microtubule Stability/doi:10.1016%2Fj.cub.2020.10.096/rivista:Current biology/anno:2021/pagina_da:658/pagina_a:667.e5/intervallo_pagine:658–667.e5/volume:31

Mitotic spindle orientation is a crucial process that defines the axis of cell division, contributing to daughter cell positioning and fate, and hence to tissue morphogenesis and homeostasis.1,2 The trimeric NuMA/LGN/Gαi complex, the major determina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c28a51a967d126c934c729537ca242
https://pubmed.ncbi.nlm.nih.gov/33275894