Zobrazeno 1 - 10
of 334
pro vyhledávání: '"Aurora kinase inhibitor"'
Autor:
Lin Wang, Furkan Yilmaz, Okan Yildirim, Beate Schölermann, Sukdev Bag, Luca Greiner, Axel Pahl, Sonja Sievers, Rebecca Scheel, Carsten Strohmann, Christopher Squire, Daniel J. Foley, Slava Ziegler, Michael Grigalunas, Herbert Waldmann
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract The pseudo‐natural product (pseudo‐NP) concept aims to combine NP fragments in arrangements that are not accessible through known biosynthetic pathways. The resulting compounds retain the biological relevance of NPs but are not yet linke
Externí odkaz:
https://doaj.org/article/9073737db646428dab117fefc2793b21
Autor:
Isabel Valero-Rubira, María Pilar Vallés, Begoña Echávarri, Patricia Fustero, María Asunción Costar, Ana María Castillo
Publikováno v:
Plants, Vol 13, Iss 6, p 772 (2024)
The use of doubled haploid (DH) technology enables the development of new varieties of plants in less time than traditional breeding methods. In microspore embryogenesis (ME), stress treatment triggers microspores towards an embryogenic pathway, resu
Externí odkaz:
https://doaj.org/article/c9d24ae12b2e49f798a07bb66bfb6bb2
Autor:
Eric M. C. Britigan, Jun Wan, Daniel K. Sam, Sarah E. Copeland, Amber L. Lasek, Laura C. F. Hrycyniak, Lei Wang, Anjon Audhya, Mark E. Burkard, Avtar Roopra, Beth A. Weaver
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Increased Aurora B protein expression, which is common in cancers, is expected to increase Aurora B kinase activity, yielding elevated phosphorylation of Aurora B substrates. In contrast, here we show that elevated expression of Aurora B reduces phos
Externí odkaz:
https://doaj.org/article/6fbce553832f4f44b8f03156cb8b9c18
Akademický článek
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Akademický článek
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Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1716 (2023)
Pancreatic cancer is one of the most aggressive forms of cancer and is the seventh leading cause of cancer deaths worldwide. Pancreatic ductal adenocarcinoma (PDAC) accounts for over 90% of pancreatic cancers. Most pancreatic cancers are recalcitrant
Externí odkaz:
https://doaj.org/article/1262c2e2a6f941afb4e82b9b14373d62
Autor:
Jun-Dan Wang, Wei Zhang, Jing-Wen Zhang, Ling Zhang, Le-Xun Wang, Hong-Sheng Zhou, Liang Long, Gui Lu, Quentin Liu, Zi-Jie Long
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 491-503 (2020)
Acute myeloid leukemia (AML) mesenchymal stem cells (MSCs) play an essential role in protecting leukemic cells from chemotherapeutic agents through activating a wide range of adhesion molecules and cytokines. Thus, more attention should be paid to at
Externí odkaz:
https://doaj.org/article/ad3243f5968d48ff907c04a0c44fc7f1
Akademický článek
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Autor:
Zhuo-Xun Wu, Yuqi Yang, Jing-Quan Wang, Wen-Min Zhou, Junyu Chen, Yi-Ge Fu, Ketankumar Patel, Zhe-Sheng Chen, Jian-Ye Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
The emergence of multidrug resistance (MDR) has been a major issue for effective cancer chemotherapy as well as targeted therapy. One prominent factor that causes MDR is the overexpression of ABCB1 transporter. In the present study, we revealed that
Externí odkaz:
https://doaj.org/article/f83228e5e95b47b99ea98d08bc626cd1
Autor:
Jennifer R. Diamond, S. G. Eckhardt, Todd M. Pitts, Adrie van Bokhoven, Dara Aisner, Daniel L. Gustafson, Anna Capasso, Sharon Sams, Peter Kabos, Kathryn Zolman, Tiffany Colvin, Anthony D. Elias, Anna M. Storniolo, Bryan P. Schneider, Dexiang Gao, John J. Tentler, Virginia F. Borges, Kathy D. Miller
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-10 (2018)
Abstract Background Triple-negative breast cancer (TNBC) remains an aggressive breast cancer subtype with limited treatment options. ENMD-2076 is a small-molecule inhibitor of Aurora and angiogenic kinases with proapoptotic and antiproliferative acti
Externí odkaz:
https://doaj.org/article/b8114fdcf25045a88513879cfaf4520b