Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aurora Holgado"'
Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids
Autor:
Alessio Borio, Aurora Holgado, Christina Passegger, Herbert Strobl, Rudi Beyaert, Holger Heine, Alla Zamyatina
Publikováno v:
Molecules, Vol 28, Iss 16, p 5948 (2023)
The Toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD-2) complex is a key receptor of the innate immune system and a major driver of inflammation that is responsible for the multifaceted defense response to Gram-negative infections. Ho
Externí odkaz:
https://doaj.org/article/ffa7754d76574592928f1f2685b16bcb
Autor:
Aurora Holgado, Harald Braun, Kenneth Verstraete, Domien Vanneste, Nico Callewaert, Savvas N. Savvides, Inna S. Afonina, Rudi Beyaert
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease. Over the past years, a large number of biologics have been developed to target cytokines in disease,
Externí odkaz:
https://doaj.org/article/f958ab7e5e0c436db448efa534a4b2eb
Autor:
Luigi Lembo-Fazio, Jean-Marc Billod, Flaviana Di Lorenzo, Ida Paciello, Mateusz Pallach, Sara Vaz-Francisco, Aurora Holgado, Rudi Beyaert, Manuel Fresno, Atsushi Shimoyama, Rosa Lanzetta, Koichi Fukase, Djamel Gully, Eric Giraud, Sonsoles Martín-Santamaría, Maria-Lina Bernardini, Alba Silipo
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Lipopolysaccharides (LPS) are potent activator of the innate immune response through the binding to the myeloid differentiation protein-2 (MD-2)/toll-like receptor 4 (TLR4) receptor complexes. Although a variety of LPSs have been characterized so far
Externí odkaz:
https://doaj.org/article/e29617bf19d146e4b4bba3e353d69f53
Autor:
Aurora Holgado, Zhuangzhuang Liu, Aigerim Aidarova, Christina Mueller, Mira Haegman, Yasmine Driege, Marja Kreike, Charlotte L. Scott, Inna S. Afonina, Rudi Beyaert
Publikováno v:
Journal of Allergy and Clinical Immunology.
Autor:
Isabelle Etienne, Rudi Beyaert, Tine Van Bergen, Jean H.M. Feyen, Inna S. Afonina, Tjing-Tjing Hu, Aurora Holgado, Inge Van Hove
Publikováno v:
Experimental eye research. 207
The progressive and sight-threatening disease, age-related macular degeneration (AMD), is a growing public health concern due to ageing demographics, with the highest unmet medical need for the advanced stage of dry AMD, geographic atrophy. The patho
Autor:
Maria Luisa Tutino, Buko Lindner, Ermenegilda Parrilli, Maria Michela Corsaro, Rudi Beyaert, Aurora Holgado, Marcello Ziaco, Rosa Lanzetta, Lynn Verstrepen, Dominik Schwudke, Angela Casillo, Filomena Sannino
Publikováno v:
ChemBioChem. 18:1845-1854
Colwellia psychrerythraea 34H is a Gram-negative cold-adapted microorganism that adopts many strategies to cope with the limitations due to the low temperatures of its habitat. In this study, we reported the complete characterization of the lipid A m
Autor:
Rudi Beyaert, Jose Antonio Garate, Holger Heine, Alessio Borio, Aurora Holgado, Alla Zamyatina
Publikováno v:
ChemMedChem. 13(21)
Despite significant advances made in the last decade in the understanding of molecular mechanisms of sepsis and in the development of clinically relevant therapies, sepsis remains the leading cause of mortality in intensive care units with increasing
Autor:
Jesús Jiménez-Barbero, Florent Cochet, Roman Jerala, Francesco Peri, Harald Braun, Lenny Zaffaroni, Fabio A. Facchini, Helena Coelho, Rudi Beyaert, Aurora Holgado, Sonsoles Martín-Santamaría, Jean-Marc Billod
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
SCIENTIFIC REPORTS
Addi. Archivo Digital para la Docencia y la Investigación
instname
Digital.CSIC. Repositorio Institucional del CSIC
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
SCIENTIFIC REPORTS
Addi. Archivo Digital para la Docencia y la Investigación
instname
Digital.CSIC. Repositorio Institucional del CSIC
13 p.-9 fig.
New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A panel of compounds with two carboxylate groups as phosphates bioisosteres, was synthesized with the same glucosamine-bis-succinyl co
New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A panel of compounds with two carboxylate groups as phosphates bioisosteres, was synthesized with the same glucosamine-bis-succinyl co
Autor:
Johannes H. Reithinger, You Maojun, Aurora Holgado, IngMarie Nilsson, Hyun Kim, Karin Öjemalm, Daniel Mattle, Patricia Lara, Abdessalem Hammed
Publikováno v:
The Journal of biological chemistry. 292(27)
The oligosaccharyltransferase complex, localized in the endoplasmic reticulum (ER) of eukaryotic cells, is responsible for the N-linked glycosylation of numerous protein substrates. The membrane protein STT3 is a highly conserved part of the oligosac
Autor:
Gunnar von Heijne, Alexey S. Ladokhin, IngMarie Nilsson, Mauricio Vargas-Uribe, Karin Öjemalm, Aurora Holgado, Yevgen O. Posokhov, Alexander Kyrychenko, Mykola V. Rodnin, George I. Makhatadze
Publikováno v:
The Journal of Membrane Biology. 248:383-394
The diphtheria toxin translocation (T) domain inserts into the endosomal membrane in response to the endosomal acidification and enables the delivery of the catalytic domain into the cell. The insertion pathway consists of a series of conformational