Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Aurora Gomez-Duran"'
Autor:
Juan Ignacio Jiménez-Loygorri, Beatriz Villarejo-Zori, Álvaro Viedma-Poyatos, Juan Zapata-Muñoz, Rocío Benítez-Fernández, María Dolores Frutos-Lisón, Francisco A. Tomás-Barberán, Juan Carlos Espín, Estela Area-Gómez, Aurora Gomez-Duran, Patricia Boya
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Macroautophagy decreases with age, and this change is considered a hallmark of the aging process. It remains unknown whether mitophagy, the essential selective autophagic degradation of mitochondria, also decreases with age. In our analysis
Externí odkaz:
https://doaj.org/article/28bf1444304f436f93a7c072feecb944
Autor:
Juan Ignacio Jiménez-Loygorri, Beatriz Villarejo-Zori, Álvaro Viedma-Poyatos, Juan Zapata-Muñoz, Rocío Benítez-Fernández, María Dolores Frutos-Lisón, Francisco A. Tomás-Barberán, Juan Carlos Espín, Estela Area-Gómez, Aurora Gomez-Duran, Patricia Boya
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f616f1b3148e4e6a9d735457dc48560f
Autor:
Shabab B. Hannan, Alvaro Sanchez-Martinez, Gloria Brea-Calvo, Aurora Gomez-Duran, Juan A. Navarro
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/f983125f3e6e40cc903121aaaf0a457c
Autor:
Mikael G. Pezet, Aurora Gomez-Duran, Florian Klimm, Juvid Aryaman, Stephen Burr, Wei Wei, Mitinori Saitou, Julien Prudent, Patrick F. Chinnery
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Using an in vitro culture system, Pezet et al. studied the influence of oxygen on the mitochondrial DNA (mtDNA) in primordial germ cell-like cells (PGCLCs) in vitro. Low oxygen levels resembling in vivo reduced the cell mtDNA content causing a geneti
Externí odkaz:
https://doaj.org/article/2ddd821695224939802015f7ff5f8b03
Autor:
Simonetta Andreazza, Colby L. Samstag, Alvaro Sanchez-Martinez, Erika Fernandez-Vizarra, Aurora Gomez-Duran, Juliette J. Lee, Roberta Tufi, Michael J. Hipp, Elizabeth K. Schmidt, Thomas J. Nicholls, Payam A. Gammage, Patrick F. Chinnery, Michal Minczuk, Leo J. Pallanck, Scott R. Kennedy, Alexander J. Whitworth
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The role of mitochondrial DNA mutations in organismal fitness and lifespan have been studied in mitochondrial mutator models with varying results. Here, the authors generate a new APOBEC1 expression-based Drosophila mutator model and show that it has
Externí odkaz:
https://doaj.org/article/f090eaf1785247208a099d9f6a996bb3
Autor:
Hannah Steele, Aurora Gomez‐Duran, Angela Pyle, Sila Hopton, Jane Newman, Renae J Stefanetti, Sarah J Charman, Jehill D Parikh, Langping He, Carlo Viscomi, Djordje G Jakovljevic, Kieren G Hollingsworth, Alan J Robinson, Robert W Taylor, Leonardo Bottolo, Rita Horvath, Patrick F Chinnery
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
Abstract Mitochondrial disorders affect 1/5,000 and have no cure. Inducing mitochondrial biogenesis with bezafibrate improves mitochondrial function in animal models, but there are no comparable human studies. We performed an open‐label observation
Externí odkaz:
https://doaj.org/article/2afb00dd500c48f4976c29a1434a3730
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
mtDNA is transmitted through the maternal line and its sequence variability, which is population specific, is assumed to be phenotypically neutral. However, several studies have shown associations between the variants defining some genetic background
Externí odkaz:
https://doaj.org/article/4b7823ca69a740739e4ec1511ac67c23
Autor:
John D. Widdrington, Aurora Gomez-Duran, Angela Pyle, Marie-Helene Ruchaud-Sparagano, Jonathan Scott, Simon V. Baudouin, Anthony J. Rostron, Penny E. Lovat, Patrick F. Chinnery, A. John Simpson
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
In order to limit the adverse effects of excessive inflammation, anti-inflammatory responses are stimulated at an early stage of an infection, but during sepsis these can lead to deactivation of immune cells including monocytes. In addition, there is
Externí odkaz:
https://doaj.org/article/e3d3a40efb8e4b5e9c5d241718315a08
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007364 (2018)
[This corrects the article DOI: 10.1371/journal.pgen.1007126.].
Externí odkaz:
https://doaj.org/article/e26f6ad3257c4f279096b9555a2c6f4d
Publikováno v:
PLoS Genetics, Vol 13, Iss 12, p e1007126 (2017)
Inherited mitochondrial DNA (mtDNA) mutations have emerged as a common cause of human disease, with mutations occurring multiple times in the world population. The clinical presentation of three pathogenic mtDNA mutations is strongly associated with
Externí odkaz:
https://doaj.org/article/a7b9f960a6764f9fb49cfd7039d5732d