Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Aurora, Navajas"'
Autor:
Jack Goddard, Jemma Castle, Emily Southworth, Anya Fletcher, Stephen Crosier, Idoia Martin-Guerrero, Miguel García-Ariza, Aurora Navajas, Julien Masliah-Planchon, Franck Bourdeaut, Christelle Dufour, Olivier Ayrault, Tobias Goschzik, Torsten Pietsch, Martin Sill, Stefan M. Pfister, Stefan Rutkowski, Stacey Richardson, Rebecca M. Hill, Daniel Williamson, Simon Bailey, Edward C. Schwalbe, Steven C. Clifford, Debbie Hicks
Publikováno v:
Acta Neuropathologica. 145:651-666
Group 4 tumours (MBGrp4) represent the majority of non-WNT/non-SHH medulloblastomas. Their clinical course is poorly predicted by current risk-factors. MBGrp4 molecular substructures have been identified (e.g. subgroups/cytogenetics/mutations), howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31310920651d70af98043527424bb4d7
https://doi.org/10.1007/s00401-023-02566-0
https://doi.org/10.1007/s00401-023-02566-0
Autor:
Angela Gutierrez-Camino, Idoia Martin-Guerrero, Nagore Garcia de Andoin, Ana Sastre, Ana Carbone Bañeres, Itziar Astigarraga, Aurora Navajas, Africa Garcia-Orad
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177421 (2017)
The locus CDKN2A/B (9p21.3), which comprises the tumor suppressors genes CDKN2A and CDKN2B and the long noncoding RNA (lncRNA) known as ANRIL (or CDKN2B-AS), was associated with childhood acute lymphoblastic leukemia (ALL) susceptibility in several g
Externí odkaz:
https://doaj.org/article/34f57d8b0a8b40549b330a93ef9c17ed
Autor:
Nagore Garcia de Andoin, Idoia Martin-Guerrero, Africa Garcia-Orad, Aizpea Echebarria-Barona, Aurora Navajas, Itziar Astigarraga, Angela Gutierrez-Camino
Publikováno v:
The Pharmacogenomics Journal. 19:564-569
Vincristine is an important drug of acute lymphoblastic leukemia (ALL) treatment protocols that can cause neurotoxicity. Patients treated with LAL/SHOP protocols often suffer from vincristine-related neurotoxicity in early phases of treatment. A gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90e885d5af7f7b709331c6feb106111
https://doi.org/10.1038/s41397-019-0081-5
https://doi.org/10.1038/s41397-019-0081-5
Autor:
Jack Goddard, Jemma Castle, Emily Southworth, Anya Fletcher, Stephen Crosier, Idoia Martin-Guerrero, Miguel Garcia-Ariza, Aurora Navajas, Julien Masliah-Planchon, Franck Bourdeaut, Christelle Dufour, Tobias Goschizk, Torsten Pietsch, Stacey Richardson, Rebecca M Hill, Daniel Williamson, Simon Bailey, Edward C Schwalbe, Steven C Clifford, Debbie Hicks
Publikováno v:
Neuro-Oncology. 24:i123-i123
Group 4 (MBGrp4) accounts for ~40% of medulloblastoma and the majority of non-WNT/non-SHH cases, yet its underpinning biology is poorly understood, and survival outcomes are not sufficiently explained by established clinico-pathological risk factors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0d1a0bf5115c313624b8efe9cf5120
https://doi.org/10.1093/neuonc/noac079.445
https://doi.org/10.1093/neuonc/noac079.445
Autor:
Elixabet López-López, Ángela Gutiérrez-Camino, Maria Ángeles Piñán, José Sánchez-Toledo, Jose Javier Uriz, Javier Ballesteros, Purificación García-Miguel, Aurora Navajas, África García-Orad
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91261 (2014)
Despite the clinical success of acute lymphoblastic leukemia (ALL) therapy, toxicity is frequent. Therefore, it would be useful to identify predictors of adverse effects. In the last years, several studies have investigated the relationship between g
Externí odkaz:
https://doaj.org/article/ca7b57da3f524d9eaeff58cf5a5cc06f
Autor:
Nagore Garcia de Andoin, Sastre Ana, Aurora Navajas, Africa Garcia-Orad, Elixabet Lopez-Lopez, Itziar Astigarraga, Maitane Umerez, Borja Santos-Zorrozua, Idoia Martin-Guerrero, Angela Gutierrez-Camino
Publikováno v:
Pharmacogenomics. 19:1403-1412
Aim: Mucositis, linked to methotrexate, daunorubicin or cyclophosphamide, is a frequent childhood acute lymphoblastic leukemia (ALL) therapy side effect. miRNAs regulate the expression of pharmacokinetic/pharmacodynamic pathway genes. SNPs in miRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c98d7dd9d92d34a91fcd13b2bc15f5
https://doi.org/10.2217/pgs-2018-0113
https://doi.org/10.2217/pgs-2018-0113
Autor:
Angela Gutierrez-Camino, Aurora Navajas, Ana Carbone-Bañeres, Vita Dolzan, Idoia Martin-Guerrero, Africa Garcia-Orad, Ana Sastre, Janez Jazbec, Itziar Astigarraga, Nagore Garcia de Andoin
Publikováno v:
Oncotarget
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Addi. Archivo Digital para la Docencia y la Investigación
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Addi. Archivo Digital para la Docencia y la Investigación
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Numerous studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays, more than 2500 miRNAs have been described, that regulate more than 50% of genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e0d516376ae06431f28a48b49cf39f
http://europepmc.org/articles/PMC5955428
http://europepmc.org/articles/PMC5955428
Autor:
Aurora Navajas, Idoia Martin-Guerrero, Itziar Astigarraga, Ana Sastre, Angela Gutierrez-Camino, Maitane Umerez, Africa Garcia-Orad, Nagore Garcia de Andoin, Borja Santos
Publikováno v:
Epigenomics. 10:409-417
Aim: Hepatotoxicity is one of the most common drug-related toxicities during the treatment of childhood acute lymphoblastic leukemia (ALL). Many genes involved in liver-specific signaling pathways are tightly controlled by miRNAs, and miRNA function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023944a5d6d48bd83115b31d8a536c22
https://doi.org/10.2217/epi-2017-0138
https://doi.org/10.2217/epi-2017-0138
Autor:
Africa Garcia-Orad, Angela Gutierrez-Camino, Idoia Martin-Guerrero, Ana Sastre, Nagore Garcia de Andoin, Itziar Astigarraga, Maitane Umerez, Aizpea Echebarria-Barona, Aurora Navajas, Borja Santos
Publikováno v:
The Pharmacogenomics Journal. 18:704-712
Vincristine (VCR), an important component of childhood acute lymphoblastic leukemia (ALL) therapy, can cause sensory and motor neurotoxicity. This neurotoxicity could lead to dose reduction or treatment discontinuation, which could in turn reduce sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1e8bc80148193933437db66bb65cd8
https://doi.org/10.1038/s41397-017-0003-3
https://doi.org/10.1038/s41397-017-0003-3
Autor:
Emily Southworth, Idoia Martin-Guerrero, Miguel Garcia-Ariza, Steven C. Clifford, Edward C. Schwalbe, Franck Bourdeaut, Daniel Williamson, Debbie Hicks, Torsten Pietsch, Tobias Goschzik, Simon Bailey, Christelle Dufour, Aurora Navajas, Stephen Crosier, Jemma Castle, Jack Goddard
Publikováno v:
Neuro-Oncology
Introduction Medulloblastoma (MB) is the most common malignant brain tumour in children. The most frequent molecular subgroup, Group 4 (MBGrp4) accounts for ~35/40% of cases, however it has the least understood underlying biology. Clinical outcomes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a237b6964e8b01de6d24691aa60326
http://europepmc.org/articles/PMC8168208
http://europepmc.org/articles/PMC8168208