Výsledky vyhledávání - "Aurita P. Puga"

Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection

Autor: Joseph Zabner, Aurita P. Puga, Michael J. Welsh, Alfredo J. Fabrega, Paul Freimuth

Although recombinant adenoviruses are attractive vectors for gene transfer to airway epithelia, they have proven to be relatively inefficient. To investigate the mechanisms of adenovirus-mediated gene transfer to airway epithelia, we examined the rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25f8ade4613eea2d869d78d6b0f05ed
https://europepmc.org/articles/PMC508289/

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Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats

Autor: Alan E. Smith, Larry A. Couture, Richard J. Gregory, Michael J. Welsh, Michael Lukason, Lynn D. Keyes, Judith A. St. George, Deanna M. Petersen, Joseph Zabner, Aurita P. Puga, Scott M. Graham

Publikováno v: Nature genetics. 6(1)

Gene therapy for cystic fibrosis (CF) will require the safe transfer of CFTR cDNA to airway epithelia in vivo. We showed previously that a recombinant adenovirus, Ad2/ CFTR–1, expresses CFTR in vitro. As adenovirus rarely integrates, treatment will

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0732eae975496de002d853962dd9391d
https://pubmed.ncbi.nlm.nih.gov/7511023

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