Crosstalk between protein kinases AKT and ERK1/2 in human lung tumor-derived cell models

Autor: Aurimas Stulpinas, Matas Sereika, Aida Vitkeviciene, Ausra Imbrasaite, Natalija Krestnikova, Audrone V. Kalvelyte

Publikováno v: Frontiers in Oncology, Vol 12 (2023)

There is no doubt that cell signaling manipulation is a key strategy for anticancer therapy. Furthermore, cell state determines drug response. Thus, establishing the relationship between cell state and therapeutic sensitivity is essential for the dev

Externí odkaz: https://doaj.org/article/46079bbd910343a5b60ce83b93844aeb

Cell-cell and cell-substratum contacts in the regulation of MAPK and Akt signalling: Importance in therapy, biopharmacy and bioproduction

Autor: Ausra Unguryte, Audrone Kalvelyte, Aurimas Stulpinas, Ausra Imbrasaite, Natalija Krestnikova, Tomas Uzusienis

Publikováno v: Cellular Signalling. 84:110034

The use of cultured cells as a tool for research, precision medicine, biopharmacy, and biomanufacturing is constantly increasing. In parallel, the role of cell-cell and cell-substratum contacts in cell functioning is increasingly validated. Adhesion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae573ae3d65f6f4e785ca1e47e86c79
https://doi.org/10.1016/j.cellsig.2021.110034

Cell death and its different modes: history of understanding and current trends

Autor: Audronė Valerija Kalvelytė, Aurimas Stulpinas

Publikováno v: International journal of biochemistry research & review, Gurgaon : SCIENCEDOMAIN International, 2019, vol. 26, iss. 1, art. no.IJBCRR .48739, p. [1-11]

Discussions about what is life continue to struggle; there are pros and cons for whether a virus is alive. However, an opposite thing – cell death – appears to be tantamount important and equally not-easygoing to define. Nevertheless, our current

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f64b9cd22b709c95a98fec1875a43a6
https://repository.vu.lt/VU:ELABAPDB41672468&prefLang=en_US

Adult Stem Cells and Anticancer Therapy

Autor: Natalija Krestnikova, Audronė Valerija Kalvelytė, Aurimas Stulpinas, Aušra Imbrasaitė

This chapter first describes the potential of stem cells in diverse biopharmaceutical applications, such as replacement therapy, disease modeling, and drug development. On the other hand, stem cells can become the targets of various potential toxicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52fdfe7c994c898ac839696300b0b7ac
https://doi.org/10.1016/b978-0-12-812522-9.00004-x

Stem cell death and survival in heart regeneration and repair

Autor: Audrone Kalvelyte, Katherine Athayde Teixeira de Carvalho, Luiz Cesar Guarita-Souza, Gabor Foldes, Aurimas Stulpinas, Eltyeb Abdelwahid

Cardiovascular diseases are major causes of mortality and morbidity. Cardiomyocyte apoptosis disrupts cardiac function and leads to cardiac decompensation and terminal heart failure. Delineating the regulatory signaling pathways that orchestrate cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c0b7c7e32c9ec127b7a7bed73ea4f5
http://hdl.handle.net/10044/1/38409