Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency

Autor: Léa Broca-Brisson, Rania Harati, Clémence Disdier, Orsolya Mozner, Romane Gaston-Breton, Auriane Maïza, Narciso Costa, Anne-Cécile Guyot, Balazs Sarkadi, Agota Apati, Matthew R Skelton, Lucie Madrange, Frank Yates, Jean Armengaud, Rifat Hamoudi, Aloïse Mabondzo

Publikováno v: eLife, Vol 12 (2023)

Creatine transporter deficiency (CTD) is an X-linked disease caused by mutations in the SLC6A8 gene. The impaired creatine uptake in the brain results in intellectual disability, behavioral disorders, language delay, and seizures. In this work, we ge

Externí odkaz: https://doaj.org/article/e52897c931c1438dbf89ad9807783b44

Long Term Gene Expression in Human Induced Pluripotent Stem Cells and Cerebral Organoids to Model a Neurodegenerative Disease

Autor: Ferid Nassor, Rafika Jarray, Denis S. F. Biard, Auriane Maïza, Dulce Papy-Garcia, Serena Pavoni, Jean-Philippe Deslys, Frank Yates

Publikováno v: Frontiers in Cellular Neuroscience, Vol 14 (2020)

Human brain organoids (mini-brains) consist of self-organized three-dimensional (3D) neural tissue which can be derived from reprogrammed adult cells and maintained for months in culture. These 3D structures manifest substantial potential for the mod

Externí odkaz: https://doaj.org/article/f8eef2923c7546f481175a47f14cc304

Variability in proteoglycan biosynthetic genes reveals new facets of heparan sulfates diversity. A systematic review and analysis

Autor: Mohand Ouidir Ouidja, Denis S.F. Biard, Sandrine Chantepie, Xavier Laffray, Gael Le Douaron, Minh-Bao Huynh, Nicolas Rebergue, Auriane Maïza, Karla Rubio, Oscar González-Velasco, Guillermo Barreto, Javier De Las Rivas, Dulce Papy-Garcia

Publikováno v: medRxiv
MedRxiv pre

Proteoglycans are complex macromolecules formed of glycosaminoglycan chains covalently linked to core proteins through a linker tetrasaccharide common to heparan sulfate proteoglycans (HSPG) and chondroitin sulfate proteoglycans (CSPG). Biosynthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c99100d1954d5b08f6261b137219903
https://hal.science/hal-03873029

3-O-sulfated heparan sulfate interactors target synaptic adhesion molecules from neonatal mouse brain and inhibit neural activity and synaptogenesis in vitro

Autor: Nazha Sidahmed-Adrar, Olivier Stettler, Damien Habert, T.H. van Kuppevelt, Patrick P. Michel, Walid Redouane, Magda Hamza, José Courty, Mohand Ouidir Ouidja, Auriane Maïza, Carine Dalle, Sandrine Chantepie, Gilles Carpentier, Dulce Papy-Garcia

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.19114. ⟨10.1038/s41598-020-76030-4⟩
Scientific Reports, 10, 1
Scientific Reports, 2020, 10 (1), pp.19114. ⟨10.1038/s41598-020-76030-4⟩
Scientific Reports, 10

Heparan sulfate (HS) chains, covalently linked to heparan sulfate proteoglycans (HSPG), promote synaptic development and functions by connecting various synaptic adhesion proteins (AP). HS binding to AP could vary according to modifications of HS cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3920d7ce994c5c36827e950b1b3debba
http://link.springer.com/article/10.1038/s41598-020-76030-4

Glycosaminoglycans from Alzheimer’s disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau

Autor: Rita Raisman-Vozari, Joao Vilares, Gilles Carpentier, Mohand Ouidir Ouidja, Dulce Papy-Garcia, Auriane Maïza, Sandrine Chantepie, Ganlin Zhang, Minh Bao Huynh

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2019, 14 (1), pp.e0209573. ⟨10.1371/journal.pone.0209573⟩
PLOS ONE
PLoS ONE, Vol 14, Iss 1, p e0209573 (2019)

International audience; Glycosaminoglycans (GAGs), including heparan sulfates and chondroitin sulfates, are major components of the extracellular matrix. Upon interacting with heparin binding growth factors (HBGF), GAGs participate to the maintainten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4702a5ed4d5bdaa46e022c8d6827831
https://hal.sorbonne-universite.fr/hal-01983707