Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Aurian P García González"'
Autor:
Brittany Rosener, Serkan Sayin, Peter O Oluoch, Aurian P García González, Hirotada Mori, Albertha JM Walhout, Amir Mitchell
Publikováno v:
eLife, Vol 9 (2020)
Metabolism of host-targeted drugs by the microbiome can substantially impact host treatment success. However, since many host-targeted drugs inadvertently hamper microbiome growth, repeated drug administration can lead to microbiome evolutionary adap
Externí odkaz:
https://doaj.org/article/7f1eba23afaf4b36ad54274bc601c6ea
Autor:
Cédric Diot, Aurian P. García-González, Andre F. Vieira, Melissa Walker, Megan Honeywell, Hailey Doyle, Olga Ponomarova, Yomari Rivera, Huimin Na, Hefei Zhang, Michael Lee, Carissa P. Olsen, Albertha J. M. Walhout
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Diot et al. use the nematode Caenorhabditis elegans as a model to identify off-target toxicity mechanisms for tamoxifen, and find that these include fatty acid metabolism and cell death, which can be modulated by different bacterial species.
Externí odkaz:
https://doaj.org/article/d1e6384868304dae8858d56f74222a07
Autor:
Cédric Diot, Aurian P. García-González, Andre F. Vieira, Melissa Walker, Megan Honeywell, Hailey Doyle, Olga Ponomarova, Yomari Rivera, Huimin Na, Hefei Zhang, Michael Lee, Carissa P. Olsen, Albertha J.M. Walhout
Publikováno v:
Nature communications. 13(1)
Tamoxifen is a selective estrogen receptor (ER) modulator that is used to treat ER-positive breast cancer, but that at high doses kills both ER-positive and ER-negative breast cancer cells. We recapitulate this off-target effect in Caenorhabditis ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2db983811451915972fe561aa6c23eb
https://pubmed.ncbi.nlm.nih.gov/36151093
https://pubmed.ncbi.nlm.nih.gov/36151093
Publikováno v:
Seminars in Colon and Rectal Surgery. 33:100901
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0191d7f2cb23e6e0fed439577e6412a5
https://doi.org/10.1016/j.scrs.2022.100901
https://doi.org/10.1016/j.scrs.2022.100901
Autor:
Brent B. Horowitz, Amy D. Holdorf, Gabrielle E. Giese, Huimin Na, Hefei Zhang, L. Safak Yilmaz, Yong-Uk Lee, Sushila Bhattacharya, Jingyan Zhang, Cédric Diot, Aurian P. García-González, Shivani Nanda, Melissa D. Walker, Xuhang Li, Albertha J.M. Walhout, Olga Ponomarova, Thomas Leland, Zeynep Mirza
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
In our group, we aim to understand metabolism in the nematode Caenorhabditis elegans and its relationships with gene expression, physiology and the response to therapeutic drugs. On March 15, 2020, a stay-at-home order was put into effect in the stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f3ef385972629f9ddb291dde5cd330
https://pubmed.ncbi.nlm.nih.gov/33398287
https://pubmed.ncbi.nlm.nih.gov/33398287
Autor:
Melissa D, Walker, Gabrielle E, Giese, Amy D, Holdorf, Sushila, Bhattacharya, Cédric, Diot, Aurian P, García-González, Brent, Horowitz, Yong-Uk, Lee, Thomas, Leland, Xuhang, Li, Zeynep, Mirza, Huimin, Na, Shivani, Nanda, Olga, Ponomarova, Hefei, Zhang, Jingyan, Zhang, L Safak, Yilmaz, Albertha J M, Walhout
Publikováno v:
bioRxiv : the preprint server for biology.
In our group, we aim to understand metabolism in the nematode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b646202903075aa3802963eef396f8f5
https://pubmed.ncbi.nlm.nih.gov/34117752
https://pubmed.ncbi.nlm.nih.gov/34117752
Autor:
Hirotada Mori, Amir Mitchell, Serkan Sayin, Aurian P García González, Peter O Oluoch, Brittany Rosener, Albertha J.M. Walhout
Publikováno v:
eLife, Vol 9 (2020)
Metabolism of host-targeted drugs by the microbiome can substantially impact host treatment success. However, since many host-targeted drugs inadvertently hamper microbiome growth, repeated drug administration can lead to microbiome evolutionary adap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04dac6a6b6b2b002984a25b8071ffd63
https://doi.org/10.7554/elife.59831
https://doi.org/10.7554/elife.59831
Publikováno v:
Drug Discovery Today: Disease Models. 28:21-26
Our body is inhabited by a large community of microorganisms referred to as our microbiota that influences almost all aspects of human physiology, including the response to thereapeutic drugs. Drugs can affect microbiota composition and the microbiot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7511234fc40ceacdef88ebb063fde65c
https://doi.org/10.1016/j.ddmod.2019.08.001
https://doi.org/10.1016/j.ddmod.2019.08.001
Publikováno v:
Current Opinion in Systems Biology. 6:46-50
The microbiota plays a critical role in human health and disease. For instance, the gut microbiota aides in the digestion of foods, thereby contributing to our ability to metabolize compounds from our diet. Recently, it has become clear that the micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c33641b136618752dfcdb97bad2a152e
https://doi.org/10.1016/j.coisb.2017.09.001
https://doi.org/10.1016/j.coisb.2017.09.001