Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Aurian Garcia"'
Autor:
Orestes Quesada, Christopher M. Gomez, Gary E. Grajales-Reyes, Aurian Garcia-Gonzalez, Carlos A. Báez-Pagán, Jose G. Grajales-Reyes, Manuel Delgado-Vélez, José A. Lasalde-Dominicci, José C. María-Ríos
Publikováno v:
Journal of Neuromuscular Diseases. 4:341-347
Muscle nicotinic acetylcholine receptor (nAChR) mutations can lead to altered channel kinetics and neuromuscular junction degeneration, a neurodegenerative disorder collectively known as slow-channel syndrome (SCS). A multivariate analysis using runn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1789029a5362c678f0ab3b14bc5b41
https://doi.org/10.3233/jnd-170226
https://doi.org/10.3233/jnd-170226
Autor:
Bryan Morales-Vargas, Manuel Delgado-Vélez, Coral M. Capó-Vélez, Jose G. Grajales-Reyes, José A. Lasalde-Dominicci, Carlos A. Báez-Pagán, Aurian Garcia-Gonzalez, Bismark Madera, Orestes Quesada
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Currently, there are no specific therapies to treat HIV-1 associated neurocognitive disorders (HAND). The HIV-1 envelope, gp120, induces neuropathological changes similar to those in HAND patients; furthermore, it triggers an upregulation of the α7-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ebdc345ddbce68ed386ca49dbf82e2
http://europepmc.org/articles/PMC5788855
http://europepmc.org/articles/PMC5788855
Autor:
Steven E. Massey, Aurian Garcia-Gonzalez, Sharlene Acosta, Luis Vicens, Miguelina Carela, Ricardo Cruet, Mariela Gines
Publikováno v:
The Journal of heredity. 106(5)
The concept of a "proteomic constraint" proposes that DNA repair capacity is positively correlated with the information content of a genome, which can be approximated to the size of the proteome (P). This in turn implies that DNA repair genes are mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4883c33f0b6508abae924ffca89b2739
https://pubmed.ncbi.nlm.nih.gov/26320243
https://pubmed.ncbi.nlm.nih.gov/26320243
Publikováno v:
Gene. 528(2)
The concept of a ‘proteomic constraint’ proposes that the information content of the proteome exerts a selective pressure to reduce mutation rates, implying that larger proteomes produce a greater selective pressure to evolve or maintain DNA repa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c9dbdf6de29103a7b4a9ff28f11f46
https://pubmed.ncbi.nlm.nih.gov/23796800
https://pubmed.ncbi.nlm.nih.gov/23796800
Publikováno v:
Frontiers in Genetics, Vol 3 (2012)
Frontiers in Genetics
Frontiers in Genetics
DNA repair is expected to be a major modulator of underlying mutation rates, however the factors affecting the distribution and complexity of DNA repair pathways have not been determined. The Proteomic Constraint hypothesis proposes that mutation rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5e2ed377625d74187e32a3d3cce434
Autor:
Francisco J. Ruiz-Fullana, Juan Trinidad-Pinedo, Germán L. Vélez-Reyes, Aurian Garcia, Adriana Baez
Publikováno v:
Cancer Research. 71:3200-3200
Objective: Head and neck cancers are a heterogeneous group of malignancies, affecting various sites with differing prognoses. Accurate and reliable stratification of head and neck squamous cell carcinomas (HNSCC) for prediction of outcomes continues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09372e25a1e109353f86979b0c1bb998
https://doi.org/10.1158/1538-7445.am2011-3200
https://doi.org/10.1158/1538-7445.am2011-3200
Autor:
Francisco J. Ruiz-Fullana, Juan Trinidad-Pinedo, Adriana Baez, Germán L. Vélez-Reyes, Aurian Garcia
Publikováno v:
Cancer Research. 71:337-337
Aims: Incidence of head and neck cancer (HNSCC) has increased in the past decades in younger adults. Oncogenic proteins E6 and E7 in HPV 16 are known to block the p53 and pRB pathways leading to abnormal cell growth and development of cancer. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aaf773665346ee8f0ca8fd1de80f7eb
https://doi.org/10.1158/1538-7445.am2011-337
https://doi.org/10.1158/1538-7445.am2011-337