Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors.

Autor: Ouvry G; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Clary L; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Tomas L; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Aurelly M; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Bonnary L; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Borde E; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Bouix-Peter C; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Chantalat L; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Defoin-Platel C; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Deret S; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Forissier M; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Harris CS; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Isabet T; Synchrotron Soleil, L'Orme des Merisiers, Saint-Aubin - BP 48, 91192 Gif-sur-Yvette Cedex, France., Lamy L; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Luzy AP; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Pascau J; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Soulet C; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Taddei A; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Taquet N; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Thoreau E; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Varvier E; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Vial E; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France., Hennequin LF; Nestlé Skin Health R&D, 2400 Route des colles, BP 87, 06902 Sophia-Antipolis Cedex, France.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Oct 04; Vol. 10 (11), pp. 1561-1567. Date of Electronic Publication: 2019 Oct 04 (Print Publication: 2019).

Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne.

Autor: Fournier JF; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Clary L; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Chambon S; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Dumais L; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Harris CS; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Millois C; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Pierre R; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Talano S; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Thoreau É; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Aubert J; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Aurelly M; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Bouix-Peter C; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Brethon A; Edelris , 115 Avenue Lacassagne , 69003 Lyon , France., Chantalat L; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Christin O; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Comino C; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., El-Bazbouz G; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Ghilini AL; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Isabet T; Synchrotron Soleil , L'Orme des Merisiers, Saint-Aubin, BP 48 , 91192 Gif-sur-Yvette Cedex, France., Lardy C; Edelris , 115 Avenue Lacassagne , 69003 Lyon , France., Luzy AP; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Mathieu C; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Mebrouk K; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Orfila D; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Pascau J; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Reverse K; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France., Roche D; Edelris , 115 Avenue Lacassagne , 69003 Lyon , France., Rodeschini V; Edelris , 115 Avenue Lacassagne , 69003 Lyon , France., Hennequin LF; Nestlé Skin Health R&D , 2400 Route des Colles, BP 87 , 06902 Sophia-Antipolis Cedex, France.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 May 10; Vol. 61 (9), pp. 4030-4051. Date of Electronic Publication: 2018 Apr 24.

In Vitro and In Silico Evaluation of Syzygium aromaticum Essential Oil: Effects on Mitochondrial Function and Cytotoxic Potential Against Cancer Cells.

Autor: Munteanu, Andreea, Gogulescu, Armand, Șoica, Codruța, Mioc, Alexandra, Mioc, Marius, Milan, Andreea, Lukinich-Gruia, Alexandra Teodora, Pricop, Maria-Alexandra, Jianu, Calin, Banciu, Christian, Racoviceanu, Roxana

Publikováno v: Plants (2223-7747); Dec2024, Vol. 13 Issue 23, p3443, 25p

Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations.

Autor: Arrighi, Giulia¹ (AUTHOR) giulia.arrighi1@stud.unifi.it, Puerta, Adrián² (AUTHOR) apuertaa@ull.es, Petrini, Andrea³ (AUTHOR) andrea.petreni@unifi.it, Hicke, Francisco J.¹ (AUTHOR) javipoke@hotmail.es, Nocentini, Alessio³ (AUTHOR) alessio.nocentini@unifi.it, Fernandes, Miguel X.² (AUTHOR) mfernand@ull.es, Padrón, José M.² (AUTHOR) jmpadron@ull.es, Supuran, Claudiu T.³ (AUTHOR) claudiu.supuran@unifi.it, Fernández-Bolaños, José G.¹ (AUTHOR) bolanos@us.es, López, Óscar¹ (AUTHOR) claudiu.supuran@unifi.it

Publikováno v: International Journal of Molecular Sciences. Jul2022, Vol. 23 Issue 14, p7685-7685. 24p.

Non-bonding energy directed designing of HDAC2 inhibitors through molecular dynamics simulation.

Autor: Dewaker, Varun, Srivastava, Pratik Narain, Verma, Saroj, Srivastava, Ajay K., Prabhakar, Yenamandra S.

Publikováno v: Journal of Biomolecular Structure & Dynamics; Dec2022, Vol. 40 Issue 24, p13432-13455, 24p