Výsledky vyhledávání - "Aurelio Marsiglio"

Targeting Integrin αV β3 with Theranostic RGD-Camptothecin Conjugates Bearing a Disulfide Linker: Biological Evaluation Reveals a Complex Scenario

Autor: Michele Caruso, Arianna Pina, Fabio Gasparri, Laura Belvisi, Daniela Arosio, Simone Zanella, Ulisse Cucchi, Daniele Donati, Cesare Gennari, Ivan Fraietta, Clara Albanese, Luca Pignataro, A. Dal Corso, Aurelio Marsiglio

Publikováno v: ChemistrySelect 2 (2017). doi:10.1002/slct.201701052
info:cnr-pdr/source/autori:Pina A.; Dal Corso A.; Caruso M.; Belvisi L.; Arosio D.; Zanella S.; Gasparri F.; Albanese C.; Cucchi U.; Fraietta I.; Marsiglio A.; Pignataro L.; Donati D.; Gennari C./titolo:Targeting Integrin ?V?3 with Theranostic RGD-Camptothecin Conjugates Bearing a Disulfide Linker: Biological Evaluation Reveals a Complex Scenario/doi:10.1002%2Fslct.201701052/rivista:ChemistrySelect/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:2

Theranostic RGD-camptothecin conjugates, possessing a disulfide linker and a fluorescent naphthalimide moiety, were synthesized and biologically evaluated. The conjugates showed nanomolar affinity for the purified ?V?3-integrin receptor. For antiprol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cbc798ca0992e0411b633301ef912d
https://doi.org/10.1002/slct.201701052

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Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases

Autor: Arturo Galvani, Nilla Avanzi, Giovanni Cervi, Barbara Salom, Marisa Montemartini, Daniela Faiardi, Claudia Piutti, Gianpaolo Fogliatto, Daniele Donati, Gianluca Papeo, Christian Orrenius, Danilo Mirizzi, Elena Casale, Aurelio Marsiglio, Francesco Casuscelli, Ferguson Ron, Matteo D'anello, Eduard R. Felder, Elena Ardini

Publikováno v: Bioorganic & Medicinal Chemistry. 21:7364-7380

A novel series of PIM inhibitors was derived from a combined effort in natural product-inspired library generation and screening. The novel pyrrolo[1,2-a]pyrazinones initial hits are inhibitors of PIM isoforms with IC50 values in the low micromolar r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3ba0082a180982c89ff216890ca016
https://doi.org/10.1016/j.bmc.2013.09.054

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Abstract 734: Thienoindoles: New highly promising agents for antibody-drug conjugates generation

Publikováno v: Cancer Research. 78:734-734

Thienoindoles are a new proprietary class of highly potent DNA minor groove alkylating agents. This class is characterized by a fused thiophene ring whose intrinsic electron-withdrawing character provides a nearly optimal increase in stability and po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d034ee8d17eb4a7b7e70715e1089086e
https://doi.org/10.1158/1538-7445.am2018-734

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Synthesis and biological evaluation of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers

Autor: Daniela Arosio, Michele Caruso, Francesco Sola, Clara Albanese, Umberto Piarulli, Daniele Donati, Laura Belvisi, Fabio Gasparri, Cesare Gennari, Luca Pignataro, Barbara Valsasina, Sonia Troiani, Alberto Dal Corso, Aurelio Marsiglio

Publikováno v: Chemistry (Weinh., Print) 21 (2015): 6921–6929. doi:10.1002/chem.201500158
info:cnr-pdr/source/autori:Dal Corso, Alberto; Caruso, Michele; Belvisi, Laura; Arosio, Daniela; Piarulli, Umberto; Albanese, Clara; Gasparri, Fabio; Marsiglio, Aurelio; Sola, Francesco; Troiani, Sonia; Valsasina, Barbara; Pignataro, Luca; Donati, Daniele; Gennari, Cesare/titolo:Synthesis and Biological Evaluation of RGD Peptidomimetic-Paclitaxel Conjugates Bearing Lysosomally Cleavable Linkers/doi:10.1002%2Fchem.201500158/rivista:Chemistry (Weinh., Print)/anno:2015/pagina_da:6921/pagina_a:6929/intervallo_pagine:6921–6929/volume:21

Two small-molecule-drug conjugates (SMDCs, 6 and 7) featuring lysosomally cleavable linkers (namely the Val-Ala and Phe-Lys peptide sequences) were synthesized by conjugation of the alpha(v)beta(3)-integrin ligand cyclo[DKP-RGD]-CH2NH2 (2) to the ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2019d707c80acd116362ec12fa145d40
https://pubmed.ncbi.nlm.nih.gov/25784522

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In vitro cell growth pharmacodynamic studies: a new nonparametric approach to determining the relative importance of drug concentration and treatment time

Autor: Paolo Magni, Dario Ballinari, M. Rocchetti, Giuseppe De Nicolao, Massimiliano Germani, Italo Poggesi, Aurelio Marsiglio

Publikováno v: Cancer Chemotherapy and Pharmacology. 52:507-513

The effect of an anticancer treatment on tumor cell proliferation in vitro can be described as a three-dimensional surface where the inhibitory effect is related to drug concentration and treatment time. The analysis of this kind of response surface

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e858d76b8c44a94d8808645bb7dfeb
https://doi.org/10.1007/s00280-003-0688-7

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Antitumor activity of FCE 26644 a new growth-factor complexing molecule

Autor: Francesco Sola, Maria Grandi, Mariella Farao, Enrico Pesenti, Nicola Mongelli, Aurelio Marsiglio

Publikováno v: Cancer Chemotherapy and Pharmacology. 36:217-222

FCE 26644, or 7,7'-(carbonyl-bis[imino-N-methyl-4, 2 pyrrole carbonyl-imino(N-methyl-4,2-pyrrole)carbonyl-imino])-bis-(1,3- naphthalene)disulfonic acid, belongs to the newly synthesized class of sulfonated derivatives of distamycin A. FCE 26644 is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933b87cc70535d682118b724ecf78e85
https://doi.org/10.1007/bf00685849

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