Effects of Cyanidin-3-O-glucoside on Synthetic and Metabolic Activity of Ethanol Stimulated Human Pancreatic Stellate Cells

Autor: Giedrius Barauskas, Kristina Kmieliute, Sonata Trumbeckaite, Antanas Gulbinas, Linas Venclauskas, Vaidotas Cesna, Rasa Baniene, Aurelija Maziukiene

Publikováno v: Phytotherapy Research. 29:1894-1900

Activated pancreatic stellate cells (PSC) play a major role in the development of chronic pancreatitis. Flavonoids (C-3-O-G) theoretically may have potential to suppress activated PSC. The aim of our study was to determine the ability of C-3-O-G to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfa8794767004bf7e91307c9418d6a89
https://doi.org/10.1002/ptr.5476

Upregulation of cugbp2 increases response of pancreatic cancer cells to chemotherapy

Autor: Albertas Daukša, Aurelija Maziukiene, Giedre Silkuniene, Aldona Jakstaite, Zilvinas Dambrauskas, Antanas Gulbinas, Kristina Kmieliute, Saulius Paškauskas

Publikováno v: Langenbeck's archives of surgery. 401(1)

Altered expression and/or function of ribosomal RNA (rRNA)-binding proteins CUGBP2/CELF2 might influence post-transcriptional regulation of the HO-1- and COX-2-mediated cytoprotective pathways and represents an important therapeutic target. The aim o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c0bbfe6cae1180c21d98416aec2540
https://pubmed.ncbi.nlm.nih.gov/26691217

Inhibition of ROS induces apoptosis and increases sensitivity to chemotherapy of pancreatic cancer cells

Autor: Giedre Silkuniene, Aldona Jakstaite, Zilvinas Dambrauskas, Antanas Gulbinas, Aurelija Maziukiene

Publikováno v: Pancreatology. 15:S21

s / Pancreatology 15 (2015) S1eS141 S21 time-specific Cre-activation a Flp-dependent, Tamoxifen-inducible CreERT2 was generated. The influence of mast cells in PDAC development and progression was investigated using mast cell-deficient mice. Results:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a799cac38f3e2d5e7ff09cb55e9f8eb
https://doi.org/10.1016/j.pan.2015.05.108

Curcumin decreases HO-1 and COX-2 expression and sensitizes pancreatic cancer cells to gemcitabine via CUGBP2 mediated post-transcriptional regulation pathway

Autor: Aurelija Maziukiene, Aldona Jakstaite, Zilvinas Dambrauskas, Antanas Gulbinas, Kristina Kmieliute

Publikováno v: Pancreatology. 15:S26

s / Pancreatology 15 (2015) S1eS141 S26 Conclusion: The simplified c-Met is an independent prognostic marker in resected PDAC. c-Met overexpression was not associated with hypoxia or gene amplification in this study.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9f5cfd9258eb5ea15dc0d4386bebce3
https://doi.org/10.1016/j.pan.2015.05.122

HuR mediated post-transcriptional regulation as a new potential adjuvant therapeutic target in chemotherapy for pancreatic cancer.

Autor: Jakstaite A; Aldona Jakstaite, Aurelija Maziukiene, Giedre Silkuniene, Kristina Kmieliute, Antanas Gulbinas, Zilvinas Dambrauskas, Institute for Digestive System Research, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania., Maziukiene A; Aldona Jakstaite, Aurelija Maziukiene, Giedre Silkuniene, Kristina Kmieliute, Antanas Gulbinas, Zilvinas Dambrauskas, Institute for Digestive System Research, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania., Silkuniene G; Aldona Jakstaite, Aurelija Maziukiene, Giedre Silkuniene, Kristina Kmieliute, Antanas Gulbinas, Zilvinas Dambrauskas, Institute for Digestive System Research, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania., Kmieliute K; Aldona Jakstaite, Aurelija Maziukiene, Giedre Silkuniene, Kristina Kmieliute, Antanas Gulbinas, Zilvinas Dambrauskas, Institute for Digestive System Research, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania., Gulbinas A; Aldona Jakstaite, Aurelija Maziukiene, Giedre Silkuniene, Kristina Kmieliute, Antanas Gulbinas, Zilvinas Dambrauskas, Institute for Digestive System Research, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania., Dambrauskas Z; Aldona Jakstaite, Aurelija Maziukiene, Giedre Silkuniene, Kristina Kmieliute, Antanas Gulbinas, Zilvinas Dambrauskas, Institute for Digestive System Research, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania.

Publikováno v: World journal of gastroenterology [World J Gastroenterol] 2015 Dec 14; Vol. 21 (46), pp. 13004-19.