Výsledky vyhledávání - "Aurelien Lesnard"

Targeting the Proangiogenic VEGF-VEGFR Protein-Protein Interface with Drug-like Compounds by In Silico and In Vitro Screening

Autor: Aurelien Lesnard, Sylvain Rault, Nicolas Inguimbert, Florent Huguenot, Pascale Coric, Serge Bouaziz, Isabelle Broutin, Christiane Garbay, Victor Goncalves, Bruno O. Villoutreix, Benoit Gautier, Maria A. Miteva, Jean-François Gaucher, Bili Seijo, Michel Vidal

Publikováno v: Chemistry and Biology
Chemistry and Biology, Elsevier, 2011, 18 (12), pp.1631-1639
HAL

Summary Protein-protein interactions play a central role in medicine, and their modulation with small organic compounds remains an enormous challenge. Because it has been noted that the macromolecular complexes modulated to date have a relatively pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45338467b9c5eb0beb7d7e8b55c8538b
https://hal.archives-ouvertes.fr/hal-01061760

Zobrazit plný text záznamu

Akademický článek

Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands

Autor: Zhicheng Zhou, Isabelle Staropoli, Anne Brelot, Peggy Suzanne, Aurélien Lesnard, Fanny Fontaine, Serge Perato, Sylvain Rault, Olivier Helynck, Fernando Arenzana-Seisdedos, Jana Sopkova-de Oliveira Santos, Bernard Lagane, Hélène Munier-Lehmann, Philippe Colin

Publikováno v: Molecules, Vol 28, Iss 3, p 1156 (2023)

The chemokine receptor CXCR4 and its ligand CXCL12 regulate leukocyte trafficking, homeostasis and functions and are potential therapeutic targets in many diseases such as HIV-1 infection and cancers. Here, we identified new CXCR4 ligands in the CERM

Externí odkaz: https://doaj.org/article/2649592c172747d6a3a95d1a2c3b0285