Soluble CD146, a biomarker and a target for preventing resistance to anti-angiogenic therapy in glioblastoma

Autor: Ahmad Joshkon, Emeline Tabouret, Wael Traboulsi, Richard Bachelier, Stéphanie Simoncini, Sandrine Roffino, Carine Jiguet-Jiglaire, Bassam Badran, Benjamin Guillet, Alexandrine Foucault-Bertaud, Aurelie S. Leroyer, Françoise Dignat-George, Olivier Chinot, Hussein Fayyad-Kazan, Nathalie Bardin, Marcel Blot-Chabaud

Publikováno v: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-12 (2022)

Abstract Rationale Glioblastoma multiforme (GBM) is a primary brain tumor with poor prognosis. The U.S. food and drug administration approved the use of the anti-VEGF antibody bevacizumab in recurrent GBM. However, resistance to this treatment is fre

Externí odkaz: https://doaj.org/article/4d1eae0ff4d841e7be8d966be7f7fe12

CD146 at the Interface between Oxidative Stress and the Wnt Signaling Pathway in Systemic Sclerosis

Autor: Xavier, Heim, Julien, Bermudez, Ahmad, Joshkon, Elise, Kaspi, Richard, Bachelier, Marie, Nollet, Mélanie, Vélier, Laetitia, Dou, Alexandre, Brodovitch, Alexandrine, Foucault-Bertaud, Aurelie S, Leroyer, Audrey, Benyamine, Aurélie, Daumas, Brigitte, Granel, Florence, Sabatier, Françoise, Dignat-George, Marcel, Blot-Chabaud, Nathalie, Bardin

Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, 2022, 142 (12), pp.3200-3210.e5. ⟨10.1016/j.jid.2022.03.038⟩

International audience; CD146 involvement was recently described in skin fibrosis of systemic sclerosis through its regulation of the Wnt pathway. Because the interaction between Wnt and ROS signaling plays a major role in fibrosis, we hypothesized t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c0f5fa58a9d3b06ccad1cef837f85c57
https://hal-amu.archives-ouvertes.fr/hal-03922484

Abstract 564: CD146 Deficiency Leads to Accelerated Atherosclerosis in Mice

Autor: Muriel G Blin, Richard Bachelier, Samantha Fernandez, Benjamin Guillet, Karim Fallague, Stéphane Robert, Nathalie Bardin, Marcel Blot-Chabaud, Françoise Dignat-George, Aurelie S Leroyer

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 35

Atherosclerosis is a chronic inflammatory disease of the large vessels and its progression is based in part on the continued recruitment of macrophages in the inflammatory wall. The well described role of CD146 in leukocyte infiltration in vitro sugg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c6b3a09a6f31afe6c0383f8ae004d60
https://doi.org/10.1161/atvb.35.suppl_1.564

Neurotrophin p75 Receptor (p75 NTR ) Promotes Endothelial Cell Apoptosis and Inhibits Angiogenesis

Autor: Aurelie S. Leroyer, Brunella Cristofaro, Marco Meloni, Paolo Madeddu, Andrea Caporali, Anton J.G. Horrevoets, Costanza Emanueli, Nicolle Kraenkel, Atsuhiko Oikawa, Gallia Graiani, Elisabetta Pani, Gaia Spinetti, Chantal M. Boulanger, Sung Ok Yoon, Graciela B. Sala-Newby

Publikováno v: Circulation Research, 103(2), e15-e26. Lippincott Williams and Wilkins
Circulation research, 103(2), e15-e26. Lippincott Williams and Wilkins
Caporali, A, Pani, E, Horrevoets, A J G, Kraenkel, N, Oikawa, A, Sala-Newby, G B, Meloni, M, Cristofaro, B, Graiani, G, Leroyer, A S, Boulanger, C M, Spinetti, G, Yoon, S O, Madeddu, P & Emanueli, C 2008, ' Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis : implications for diabetes-induced impaired neovascularization in ischemic limb muscles ', Circulation Research, vol. 103, no. 2, pp. e15-26 . https://doi.org/10.1161/CIRCRESAHA.108.177386
Caporali, A, Pani, E, Horrevoets, A J G, Kraenkel, N, Oikawa, A, Sala-Newby, G B, Meloni, M, Cristofaro, B, Graiani, G, Leroyer, A S, Boulanger, C M, Spinetti, G, Yoon, S O, Madeddu, P & Emanueli, C 2008, ' Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles ', Circulation Research, vol. 103, no. 2, pp. e15-e26 . https://doi.org/10.1161/CIRCRESAHA.108.177386

Diabetes impairs endothelial function and reparative neovascularization. The p75 receptor of neurotrophins (p75 NTR ), which is scarcely present in healthy endothelial cells (ECs), becomes strongly expressed by capillary ECs after induction of periph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed9c7f7a496e5dd3480a5cf85d44f99
https://doi.org/10.1161/circresaha.108.177386