Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Aurelie Guislain"'
Autor:
Fiamma Salerno, Aurelie Guislain, Julian J. Freen-Van Heeren, Benoit P. Nicolet, Howard A. Young, Monika C. Wolkers
Publikováno v:
OncoImmunology, Vol 8, Iss 2 (2019)
Protective T cell responses against tumors require the production of Interferon gamma (IFN-γ). However, tumor-infiltrating T cells (TILs) gradually lose their capacity to produce IFN-γ and therefore fail to clear malignant cells. Dissecting the und
Externí odkaz:
https://doaj.org/article/3464888a53fa49779ff2a55a060dfefc
Autor:
Iosifina P. Foskolou, Pedro P Cunha, Eleanor Minogue, Benoit P Nicolet, Aurelie Guislain, Christian Jorgensen, Nordin D Zandhuis, Laura Barbieri, David Bargiela, Demitris Nathanael, Petros Tyrakis, Asis Palazon, Monika C Wolkers, Randall S Johnson
SUMMARY2-hydroxyglutarate (2HG) is a by-product of the TCA cycle, and is readily detected in the tissues of healthy individuals. 2HG is found in two enantiomeric forms: S-2HG and R-2HG. Here, we investigate the differential roles of these two enantio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3171c013fcf504e83cd81bb30e0da657
https://doi.org/10.1101/2022.08.18.504372
https://doi.org/10.1101/2022.08.18.504372
Autor:
Floris P. J. van Alphen, Sander Engels, Julian J Freen-van Heeren, Natali Paravinja, Anouk Jurgens, Fiamma Salerno, Aurelie Guislain, Branka Popović, Monika C. Wolkers, Benoit P Nicolet, Maartje van den Biggelaar
Publikováno v:
Cell Reports. 42:112419
Potent T cell responses against infections and malignancies depend on the release of effector molecules, such as pro-inflammatory cytokines. Because effector molecules can be toxic, their production is tightly regulated through post-transcriptional e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155117c7bd7d733062ba668f56521a84
https://doi.org/10.1016/j.celrep.2023.112419
https://doi.org/10.1016/j.celrep.2023.112419
Autor:
Suzanne M. Castenmiller, Nandhini Kanagasabesan, Aurélie Guislain, Benoît P. Nicolet, Marleen M. van Loenen, Kim Monkhorst, Alexander A.F.A. Veenhof, Egbert F. Smit, Koen J. Hartemink, John B.A.G. Haanen, Rosa de Groot, Monika C. Wolkers
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Adoptive transfer of tumor infiltrating lymphocytes (TIL therapy) has proven highly effective for treating solid cancers, including non-small cell lung cancer (NSCLC). However, not all patients benefit from this therapy for yet unknown reasons. Defin
Externí odkaz:
https://doaj.org/article/765f3c5d599a4883af3b95a3fce40f0d
Publikováno v:
Journal of immunology (Baltimore, Md.. American Association of Immunologists
CD4+ T cells are key contributors in the induction of adaptive immune responses against pathogens. Even though CD4+ T cells are primarily classified as noncytotoxic helper T cells, it has become appreciated that a subset of CD4+ T cells is cytotoxic.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07409d2a6374115af3a827c20e155471
https://doi.org/10.4049/jimmunol.2100138
https://doi.org/10.4049/jimmunol.2100138
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 207(12)
CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::225b3e6dfd5b2e5d1965de247e384bd5
https://pubmed.ncbi.nlm.nih.gov/34782446
https://pubmed.ncbi.nlm.nih.gov/34782446
Publikováno v:
European journal of immunology, 50(7), 949-958. Wiley-VCH Verlag
European Journal of Immunology
European Journal of Immunology
Long‐lasting CD8+ T cell responses are critical in combatting infections and tumors. The pro‐inflammatory cytokine IFN‐γ is a key effector molecule herein. We recently showed that in murine T cells the production of IFN‐γ is tightly regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c47ee9245e1b341d71d15e4a9c3982
Autor:
Benoit P Nicolet, Aurelie Guislain, Julian J Freen-van Heeren, Monika C. Wolkers, Fiamma Salerno, Howard A. Young
Publikováno v:
OncoImmunology, Vol 8, Iss 2 (2019)
Oncoimmunology, 8(2):e1532762. Landes Bioscience
Oncoimmunology, 8(2):e1532762. Landes Bioscience
Protective T cell responses against tumors require the production of Interferon gamma (IFN-γ). However, tumor-infiltrating T cells (TILs) gradually lose their capacity to produce IFN-γ and therefore fail to clear malignant cells. Dissecting the und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56a696bf2fad6eff9c91ce24daeaffa
https://doi.org/10.1080/2162402x.2018.1532762
https://doi.org/10.1080/2162402x.2018.1532762
Autor:
Fiamma, Salerno, Julian J, Freen-van Heeren, Aurelie, Guislain, Benoit P, Nicolet, Monika C, Wolkers
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 202(3)
Optimal T cell activation requires Ag recognition through the TCR, engagement of costimulatory molecules, and cytokines. T cells can also directly recognize danger signals through the expression of TLRs. Whether TLR ligands have the capacity to provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ebf505cb8ba68dcb0281bc9be4746d4
https://pubmed.ncbi.nlm.nih.gov/30578304
https://pubmed.ncbi.nlm.nih.gov/30578304