Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Aurelie Contrepas"'
Autor:
Judith Peters, Michael Schwake, Ulrich Wenzel, Christian Krebs, Geneviève Nguyen, Harry van Goor, Aurelie Contrepas, Sascha Lange, Thorsten Wiech, Erfan Ahadzadeh, Michael Bader, Alva Rosendahl, Gianina Niemann, Rolf A.K. Stahl
Publikováno v:
Laboratory Investigation, 94(8), 863-872. SPRINGERNATURE
Binding of renin and prorenin to the (pro)renin receptor (PRR) increases their enzymatic activity and upregulates the expression of pro-fibrotic genes in vitro. Expression of PRR is increased in the heart and kidney of hypertensive and diabetic anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f735bf278a000e013bf4a1bd5b535a
https://doi.org/10.1038/labinvest.2014.83
https://doi.org/10.1038/labinvest.2014.83
Autor:
Laurent Muller, Pierre Corvol, Geneviève Nguyen, Aurelie Contrepas, Diane Bracquart, Christelle Cousin
Publikováno v:
Hypertension
Hypertension, American Heart Association, 2009, 53 (6), pp.1077-1082. ⟨10.1161/HYPERTENSIONAHA.108.127258⟩
Hypertension, American Heart Association, 2009, 53 (6), pp.1077-1082. ⟨10.1161/HYPERTENSIONAHA.108.127258⟩
International audience; The (pro)renin receptor [(P)RR] is a 35-kDa transmembrane protein that plays a pivotal role in angiotensin tissue generation and in nonproteolytic prorenin activation. We detected a soluble form of (P)RR [s(P)RR; 28 kDa] in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0e5b89ebb956f38d9b989b7fa5ae66
https://doi.org/10.1161/hypertensionaha.108.127258
https://doi.org/10.1161/hypertensionaha.108.127258
Autor:
Friedrich C. Luft, Anette Fiebeler, A.H. Jan Danser, Sandra Feldt, Maren Wellner, Geneviève Nguyen, Aurelie Contrepas, Wendy W. Batenburg, Michael Bader, Ulrike Maschke, Istvan Mazak, Heda Kvakan, Céline Burcklé, Ralf Dechend, Dominik N. Müller
Publikováno v:
Hypertension, 51(3), 682-688. Lippincott Williams & Wilkins
The recently cloned (pro)renin receptor [(P)RR] mediates renin-stimulated cellular effects by activating mitogen-activated protein kinases and promotes nonproteolytic prorenin activation. In vivo, (P)RR is said to be blocked with a peptide consisting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e091dadeb9c146163d67205d5448611
https://doi.org/10.1161/hypertensionaha.107.101444
https://doi.org/10.1161/hypertensionaha.107.101444
Publikováno v:
Journal of nephrology. 23(5)
The discovery of a (pro)renin receptor ((P)RR) and the introduction of renin inhibitors in the clinic has brought prorenin, the inactive proenzyme form of renin, back into the spotlight. The (P)RR binds both renin and its inactive precursor prorenin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ffb3a31c57e8ced943653aa10d4ad33
https://pubmed.ncbi.nlm.nih.gov/20383869
https://pubmed.ncbi.nlm.nih.gov/20383869
Autor:
Karl J. Franek, Geneviève Nguyen, Joy Walker, Charles E. Schwartz, Christian Giaume, Annette Koulakoff, Aurelie Contrepas, Fatimunnisa Qadri, Pierre Corvol
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 297(2)
The (pro)renin receptor [(P)RR] plays a pivotal role in the renin-angiotensin system. Experimental models emphasize the role of (P)RR in organ damage associated with hypertension and diabetes. However, a mutation of the (P)RR gene, resulting in frame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af664efa8336cda5e12c74d59f6987d6
https://pubmed.ncbi.nlm.nih.gov/19494175
https://pubmed.ncbi.nlm.nih.gov/19494175
Autor:
Friedrich C. Luft, Dominik N. Müller, Geneviève Nguyen, Aurelie Contrepas, Michael Boschmann, Petra Gratze, Ralf Dechend, Jochen Springer, Susanne Klaus, Stefan Engeli, Ralph Plehm, Jeanette Malchow, Jürgen Janke, Sabine Graeske, Fatimunnisa Qadri
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 53(3)
Renin initiates angiotensin II formation and has no other known functions. We observed that transgenic rats (TGR) overexpressing the human renin gene (hREN) developed moderate obesity with increased body fat mass and glucose intolerance compared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bf525c625c3618f06171693735c6ea
https://pubmed.ncbi.nlm.nih.gov/19171793
https://pubmed.ncbi.nlm.nih.gov/19171793
Autor:
Elke Persohn, Dominik N Mueller, Wieslawa Maniara, Helmut Schuetz, Liang Jin, Aurelie Contrepas, A.H. Jan Danser, Randy Lee Webb, Yinong Zhou, Frederick Cumin, Sandra Feldt, Geneviève Nguyen, Hong Xuan, David Louis Feldman
Publikováno v:
Hypertension, 52(1), 130-136. Lippincott Williams & Wilkins
The aim of this study was to explore the effects of the renin inhibitor aliskiren in streptozotocin-diabetic TG(mRen-2)27 rats. Furthermore, we investigated in vitro the effect of aliskiren on the interactions between renin and the (pro)renin recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84783aed9eafe51c0300b1106b1cfb3
https://pubmed.ncbi.nlm.nih.gov/18490520
https://pubmed.ncbi.nlm.nih.gov/18490520