Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Aureliano Zana"'
Autor:
Lydia Bisbal Lopez, Domenico Ravazza, Matilde Bocci, Aureliano Zana, Lucrezia Principi, Sheila Dakhel Plaza, Andrea Galbiati, Ettore Gilardoni, Jörg Scheuermann, Dario Neri, Luca Pignataro, Cesare Gennari, Samuele Cazzamalli, Alberto Dal Corso
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Immune-stimulating antibody conjugates (ISACs) equipped with imidazoquinoline (IMD) payloads can stimulate endogenous immune cells to kill cancer cells, ultimately inducing long-lasting anticancer effects. A novel ISAC was designed, featuring the IMD
Externí odkaz:
https://doaj.org/article/b9edd8a96d8444cc849c81174ca18bed
Autor:
Andrea Galbiati, Aureliano Zana, Chiara Borsari, Marco Persico, Stefania Bova, Oleh Tkachuk, Alexandra Ioana Corfu, Lucia Tamborini, Nicoletta Basilico, Caterina Fattorusso, Stefano Bruno, Silvia Parapini, Paola Conti
Publikováno v:
Molecules, Vol 28, Iss 7, p 3172 (2023)
Chiral natural compounds are often biosynthesized in an enantiomerically pure fashion, and stereochemistry plays a pivotal role in biological activity. Herein, we investigated the significance of chirality for nature-inspired 3-Br-acivicin (3-BA) and
Externí odkaz:
https://doaj.org/article/640877a73467454187830b2b5472f319
Autor:
Francesco Bartoli, Philip Elsinga, Luiza Reali Nazario, Aureliano Zana, Andrea Galbiati, Jacopo Millul, Francesca Migliorini, Samuele Cazzamalli, Dario Neri, Riemer H. J. A. Slart, Paola Anna Erba
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 958 (2022)
FAP-targeted radiopharmaceuticals represent a breakthrough in cancer imaging and a viable option for therapeutic applications. OncoFAP is an ultra-high-affinity ligand of FAP with a dissociation constant of 680 pM. OncoFAP has been recently discovere
Externí odkaz:
https://doaj.org/article/9b8e960e1d47425a9a726420423c1258
Autor:
Aureliano Zana, Andrea Galbiati, Ettore Gilardoni, Matilde Bocci, Jacopo Millul, Theo Sturm, Riccardo Stucchi, Abdullah Elsayed, Lisa Nadal, Martina Cirillo, Wolfgang Roll, Lars Stegger, Inga Asmus, Philipp Backhaus, Michael Schäfers, Dario Neri, Samuele Cazzamalli
Publikováno v:
Clinical Cancer Research, 28 (24)
Purpose: Small molecule drug conjugates (SMDC) are modular anticancer prodrugs that include a tumor-targeting small organic ligand, a cleavable linker, and a potent cytotoxic agent. Most of the SMDC products that have been developed for clinical appl
Autor:
Samuele Cazzamalli, Dario Neri, Alessandra Villa, Emanuele Puca, Sheila Dakhel Plaza, Aureliano Zana, Christiane Krudewig, Jacopo Millul
Supplementary material: chemical synthesis and biological characterisation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9a36294bfc4dcfa1d87db22b1b2b04
https://doi.org/10.1158/1535-7163.22521177
https://doi.org/10.1158/1535-7163.22521177
Autor:
Samuele Cazzamalli, Dario Neri, Michael Schäfers, Philipp Backhaus, Inga Asmus, Lars Stegger, Wolfgang Roll, Martina Cirillo, Lisa Nadal, Abdullah Elsayed, Riccardo Stucchi, Theo Sturm, Jacopo Millul, Matilde Bocci, Ettore Gilardoni, Andrea Galbiati, Aureliano Zana
Purpose:Small molecule drug conjugates (SMDC) are modular anticancer prodrugs that include a tumor-targeting small organic ligand, a cleavable linker, and a potent cytotoxic agent. Most of the SMDC products that have been developed for clinical appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d9b4fc3d804e23c51f17e5d8a977c0
https://doi.org/10.1158/1078-0432.c.6532977.v1
https://doi.org/10.1158/1078-0432.c.6532977.v1
Autor:
Samuele Cazzamalli, Dario Neri, Michael Schäfers, Philipp Backhaus, Inga Asmus, Lars Stegger, Wolfgang Roll, Martina Cirillo, Lisa Nadal, Abdullah Elsayed, Riccardo Stucchi, Theo Sturm, Jacopo Millul, Matilde Bocci, Ettore Gilardoni, Andrea Galbiati, Aureliano Zana
Supplementary Information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13fbe6a48db52c90a2131cbe7e5fcc3
https://doi.org/10.1158/1078-0432.22489545.v1
https://doi.org/10.1158/1078-0432.22489545.v1
Autor:
Andrea Galbiati, Aureliano Zana, Matilde Bocci, Jacopo Millul, Abdullah Elsayed, Jacqueline Mock, Dario Neri, Samuele Cazzamalli
Publikováno v:
J Nucl Med
Imaging procedures based on small-molecule radioconjugates targeting fibroblast activation protein (FAP) have recently emerged as a powerful tool for the diagnosis of a wide variety of tumors. However, the therapeutic potential of radiolabeled FAP-ta
Autor:
Andrea Galbiati, Stefania Bova, Raffaella Pacchiana, Chiara Borsari, Marco Persico, Aureliano Zana, Stefano Bruno, Massimo Donadelli, Caterina Fattorusso, Paola Conti
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a key glycolytic enzyme, plays a crucial role in the energy metabolism of cancer cells and has been proposed as a valuable target for the development of anticancer agents. Among a series of 5-substitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca28cc79aaebb61fa83b66be370da21
https://hdl.handle.net/11588/919206
https://hdl.handle.net/11588/919206
Autor:
Hans-Jörg Breyholz, Samuele Cazzamalli, Andrea Galbiati, Wolfgang Roll, Paulina Marie Dorten, Michael Schäfers, Jacqueline Mock, Inga Asmus, Jacopo Millul, Florian Büther, Matthias Weckesser, Dario Neri, J. Tio, Klaus P. Schäfers, Philipp Backhaus, Stefan Wagner, Florian Gierse, Matthias C. Burg, Aureliano Zana, Sven Hermann, Juela Cufe
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging, 49 (6)
Purpose The fibroblast activation protein (FAP) is an emerging target for molecular imaging and therapy in cancer. OncoFAP is a novel small organic ligand for FAP with very high affinity. In this translational study, we establish [Ga-68]Ga-OncoFAP-DO