Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Aurelia Lugea"'
Autor:
Yaroslav Teper, Linda Ye, Richard T. Waldron, Aurelia Lugea, Xiaoying Sun, James Sinnett-Smith, Oscar J. Hines, Stephen J. Pandol, Enrique Rozengurt, Guido Eibl
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC), a highly lethal disease with limited therapeutic options, may benefit from repurposing of FDA-approved drugs in preventive or interceptive strategies in high-risk populations. Previous animal studies
Externí odkaz:
https://doaj.org/article/6608e1bba2a74358ac50303e509a41fb
Autor:
Richard T. Waldron, Aurelia Lugea, Hui-Hua Chang, Hsin-Yuan Su, Crystal Quiros, Michael S. Lewis, Mingtian Che, V. Krishnan Ramanujan, Enrique Rozengurt, Guido Eibl, Stephen J. Pandol
Publikováno v:
Cancers, Vol 16, Iss 8, p 1593 (2024)
Diet-induced obesity (DIO) promotes pancreatic ductal adenocarcinoma (PDAC) in mice expressing KRasG12D in the pancreas (KC mice), but the precise mechanisms remain unclear. Here, we performed multiplex quantitative proteomic and phosphoproteomic ana
Externí odkaz:
https://doaj.org/article/710601d70c5b44aaaab53d5b3b62bd8a
Autor:
Michelle M. Cooley, Diana D.H. Thomas, Kali Deans, Yajing Peng, Aurelia Lugea, Stephen J. Pandol, Luigi Puglielli, Guy E. Groblewski
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 725-738 (2021)
Background & Aims: Maintaining endoplasmic reticulum (ER) proteostasis is essential for pancreatic acinar cell function. Under conditions of severe ER stress, activation of pathogenic unfolded protein response pathways plays a central role in the dev
Externí odkaz:
https://doaj.org/article/5dd29e6836a94d13869244ae95e51c4a
Autor:
Cheng Hu, Liyuan Yin, Zhiyao Chen, Richard T. Waldron, Aurelia Lugea, Yiyun Lin, Xiaoqian Zhai, Li Wen, Yuan-Ping Han, Stephen J. Pandol, Lihui Deng, Qing Xia
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 6375-6385 (2021)
Chronic pancreatitis (CP) is characterized by irreversible fibro-inflammatory changes induced by pancreatic stellate cell (PSC). Unresolved or recurrent injury causes dysregulation of biological process following AP, which would cause CP. Here, we sy
Externí odkaz:
https://doaj.org/article/e2404d6e0c284a32b752113efbf423bb
Autor:
Qiong Wei, Liang Qi, Hao Lin, Dechen Liu, Xiangyun Zhu, Yu Dai, Richard T. Waldron, Aurelia Lugea, Mark O. Goodarzi, Stephen J. Pandol, Ling Li
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The clinical significance of diabetes arising in the setting of pancreatic disease (also known as diabetes of the exocrine pancreas, DEP) has drawn more attention in recent years. However, significant improvements still need to be made in the recogni
Externí odkaz:
https://doaj.org/article/4295474b9cf7489ea19a72da3bd8e7e4
Autor:
Cheng Hu, Jiayue Yang, Hsin-Yuan Su, Richard T. Waldron, Mengmeng Zhi, Ling Li, Qing Xia, Stephen J. Pandol, Aurelia Lugea
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Background: Yes-associated protein 1 (YAP), a transcriptional co-activator and major effector of the Hippo pathway, regulates cell differentiation and morphology in many cell types and supports aberrant tumor growth. Recent studies showed that YAP is
Externí odkaz:
https://doaj.org/article/0b67bfe257a349cb945c3737f6c2a37d
Autor:
Richard T. Waldron, Hsin-Yuan Su, Honit Piplani, Joseph Capri, Whitaker Cohn, Julian P. Whitelegge, Kym F. Faull, Sugunadevi Sakkiah, Ravinder Abrol, Wei Yang, Bo Zhou, Michael R. Freeman, Stephen J. Pandol, Aurelia Lugea
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 479-497 (2018)
Background & Aims: Heavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreat
Externí odkaz:
https://doaj.org/article/3fb25426f99449cf82738f6cbeb12ac8
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Background and Aims: Patients who have an episode of acute pancreatitis (AP) frequently develop diabetes mellitus (DM) over time. The reported incidence of DM after AP varies depending on the severity, etiology and the extent of pancreatic necrosis d
Externí odkaz:
https://doaj.org/article/90bad8fee44a4777b26a5ff8944e95aa
Autor:
Mingtian Che, Soo-Mi Kweon, Jia-Ling Teo, Yate-Ching Yuan, Laleh G. Melstrom, Richard T. Waldron, Aurelia Lugea, Raul A. Urrutia, Stephen J. Pandol, Keane K. Y. Lai
Publikováno v:
Cancers, Vol 12, Iss 6, p 1476 (2020)
Background: Although cyclic AMP-response element binding protein-binding protein (CBP)/β-catenin signaling is known to promote proliferation and fibrosis in various organ systems, its role in the activation of pancreatic stellate cells (PSCs), the k
Externí odkaz:
https://doaj.org/article/e21c19489cdf434690ea7f856d433433
Autor:
Karuna Rasineni, Mukund P. Srinivasan, Appakalai N. Balamurugan, Bhupendra S. Kaphalia, Shaogui Wang, Wen-Xing Ding, Stephen J. Pandol, Aurelia Lugea, Liz Simon, Patricia E. Molina, Peter Gao, Carol A. Casey, Natalia A. Osna, Kusum K. Kharbanda
Publikováno v:
Biomolecules, Vol 10, Iss 5, p 669 (2020)
Chronic excessive alcohol use is a well-recognized risk factor for pancreatic dysfunction and pancreatitis development. Evidence from in vivo and in vitro studies indicates that the detrimental effects of alcohol on the pancreas are from the direct t
Externí odkaz:
https://doaj.org/article/19878899bdaf4365ad8e7fe4283c888d