Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Aurel Prosz"'
Autor:
Miklos Diossy, Viktoria Tisza, Hua Li, Pranshu Sahgal, Jia Zhou, Zsofia Sztupinszki, Denise Young, Darryl Nousome, Claire Kuo, Jiji Jiang, Yongmei Chen, Reinhard Ebner, Isabell A. Sesterhenn, Joel T. Moncur, Gregory T. Chesnut, Gyorgy Petrovics, Gregory T. Klus, Gabor Valcz, Pier Vitale Nuzzo, Dezso Ribli, Judit Börcsök, Aurel Prosz, Marcin Krzystanek, Thomas Ried, David Szuts, Kinza Rizwan, Salma Kaochar, Shailja Pathania, Alan D. D’Andrea, Istvan Csabai, Shiv Srivastava, Matthew L. Freedman, Albert Dobi, Sandor Spisak, Zoltan Szallasi
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)
Abstract We analyzed genomic data from the prostate cancer of African- and European American men to identify differences contributing to racial disparity of outcome. We also performed FISH-based studies of Chromodomain helicase DNA-binding protein 1
Externí odkaz:
https://doaj.org/article/3508a45a6daf4e298c016ff52086528b
Autor:
Aurel Prosz, Pranshu Sahgal, Brandon M. Huffman, Zsofia Sztupinszki, Clare X. Morris, David Chen, Judit Börcsök, Miklos Diossy, Viktoria Tisza, Sandor Spisak, Pornlada Likasitwatanakul, Orsolya Rusz, Istvan Csabai, Michael Cecchini, Yasmine Baca, Andrew Elliott, Peter Enzinger, Harshabad Singh, Jessalyn Ubellaker, Jean-Bernard Lazaro, James M. Cleary, Zoltan Szallasi, Nilay S. Sethi
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Homologous recombination (HR) and nucleotide excision repair (NER) are the two most frequently disabled DNA repair pathways in cancer. HR-deficient breast, ovarian, pancreatic and prostate cancers respond well to platinum chemotherapy and PA
Externí odkaz:
https://doaj.org/article/b6b069037e684be89e6db272774fcef6
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTImmune checkpoint inhibitor therapy has dramatically improved survival in a significant subset of patients with several solid tumor types. Increasing the number of patients benefitting from this form of therapy is an important translational r
Externí odkaz:
https://doaj.org/article/1a48aff26a6740e6907bc8919e34c69b
Autor:
Aurel Prosz, Orsolya Pipek, Judit Börcsök, Gergely Palla, Zoltan Szallasi, Sandor Spisak, István Csabai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Ageing is often characterised by progressive accumulation of damage, and it is one of the most important risk factors for chronic disease development. Epigenetic mechanisms including DNA methylation could functionally contribute to organisma
Externí odkaz:
https://doaj.org/article/d55cd8a828df4fc898caef58429cfbca
Autor:
Aurel Prosz, Haohui Duan, Viktoria Tisza, Pranshu Sahgal, Sabine Topka, Gregory T. Klus, Judit Börcsök, Zsofia Sztupinszki, Timothy Hanlon, Miklos Diossy, Laura Vizkeleti, Dag Rune Stormoen, Istvan Csabai, Helle Pappot, Joseph Vijai, Kenneth Offit, Thomas Ried, Nilay Sethi, Kent W. Mouw, Sandor Spisak, Shailja Pathania, Zoltan Szallasi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Due to a demonstrated lack of DNA repair deficiencies, clear cell renal cell carcinoma (ccRCC) has not benefitted from targeted synthetic lethality-based therapies. We investigated whether nucleotide excision repair (NER) deficiency is prese
Externí odkaz:
https://doaj.org/article/939969bbc4324201be410156a45cd9e5
Autor:
Aurel Prosz, Pranshu Sahgal, Brandon M. Huffman, Zsofia Sztupinszki, Clare X. Morris, David Chen, Judit Börcsök, Miklos Diossy, Viktoria Tisza, Sandor Spisak, Pornlada Likasitwatanakul, Orsolya Rusz, Istvan Csabai, Michael Cecchini, Yasmine Baca, Andrew Elliott, Peter Enzinger, Harshabad Singh, Jessalyn Ubellaker, Jean-Bernard Lazaro, James M. Cleary, Zoltan Szallasi, Nilay S. Sethi
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/7b071e78f9934ab7a55cfa9bc5e11b2f
Autor:
Kristijonas Žemaitis, Agatheeswaran Subramaniam, Roman Galeev, Aurel Prosz, Maria Jassinskaja, Jenny Hansson, Jonas Larsson
Publikováno v:
Experimental Hematology. 115:20-29
The molecular mechanisms regulating key fate decisions of hematopoietic stem cells (HSCs) remain incompletely understood. Here, we targeted global shRNA libraries to primary human hematopoietic stem and progenitor cells (HSPCs) to screen for modifier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7571f264b952698eb98afd27c5e0563d
https://doi.org/10.1016/j.exphem.2022.08.004
https://doi.org/10.1016/j.exphem.2022.08.004
Autor:
Zoltan Szallasi, Mansoor R. Mirza, Maj K. Kjeldsen, Nanna Cornelius, Aurel Prosz, Judit Borcsok, Miklos Diossy, Zsofia Sztupinszki
Indel profiles, TCGA WES cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6d8f56e50d39171890e0c4b7f62791
https://doi.org/10.1158/1078-0432.22481075.v1
https://doi.org/10.1158/1078-0432.22481075.v1
Autor:
Zoltan Szallasi, Kent W. Mouw, Søren Brunak, Istvan Csabai, Helle Pappot, Dag R. Stormoen, Orsolya Rusz, Sandor Spisak, Viktoria Tisza, Aurel Prosz, Zsofia Sztupinszki, Miklos Diossy, Judit Börcsök
Description of supplementary materials and methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c03033ec2915dbad21569b9b0443ae
https://doi.org/10.1158/1078-0432.22480478
https://doi.org/10.1158/1078-0432.22480478
Autor:
Zoltan Szallasi, Mansoor R. Mirza, Maj K. Kjeldsen, Nanna Cornelius, Aurel Prosz, Judit Borcsok, Miklos Diossy, Zsofia Sztupinszki
Purpose:Homologous recombination (HR) deficiency (HRD) is one of the key determinants of PARP inhibitor response in ovarian cancer, and its accurate detection in tumor biopsies is expected to improve the efficacy of this therapy. Because HRD induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84513c1f029ebdef7fe4f6ac8e72a969
https://doi.org/10.1158/1078-0432.c.6530609.v1
https://doi.org/10.1158/1078-0432.c.6530609.v1