Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Aurawan Vongs"'
Autor:
Hua V Lin, Dunlu Chen, Zhu Shen, Lei Zhu, Xuesong Ouyang, Aurawan Vongs, Yanqing Kan, John M Levorse, Edward J Kowalik, Daphne M Szeto, Xiaorui Yao, Jianying Xiao, Shirley Chen, Jinqi Liu, Marga Garcia-Calvo, Myung K Shin, Shirly Pinto
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54480 (2013)
Diacylglycerol acyltransferase-1 (DGAT1) is a potential therapeutic target for treatment of obesity and related metabolic diseases. However, the degree of DGAT1 inhibition required for metabolic benefits is unclear. Here we show that partial DGAT1 de
Externí odkaz:
https://doaj.org/article/04d6fea951f2478297b3dfeed85ea767
Autor:
Doreen E. Cashen, Constantin Tamvakopoulos, Qianping Peng, William J. Martin, David H. Weinberg, Charles Rosenblum, Arthur A. Patchett, Tanya MacNeil, Patrick G. Pollard, Zhixiong Ye, Raman K. Bakshi, Ralph A. Stearns, Rubana N. Kalyani, Palucki Brenda, Joseph M. Metzger, Alison M. Strack, Lex H.T. Van der Ploeg, D. Euan MacIntyre, Iyassu K. Sebhat, Aurawan Vongs, Airu S. Chen, Ravi P. Nargund, Liangqin Guo, Matthew J. Wyvratt, Randy R. Miller, Rui Tang, Howard Y. Chen, Khaled J. Barakat
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3501-3505
A novel isoquinuclidine containing selective melanocortin subtype-4 receptor small molecule agonist, 3 (RY764), is reported. Its in vivo characterization revealed mechanism-based food intake reduction and erectile activity augmentation in rodents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec96b03aa1e5f2ba3d3c429b0a51544
https://doi.org/10.1016/j.bmcl.2005.05.109
https://doi.org/10.1016/j.bmcl.2005.05.109
Publikováno v:
Regulatory Peptides. 120:113-118
The melanocortin 4 receptor (MC4-R) is a Galpha s-coupled receptor known to increase cAMP production following agonist stimulation. We demonstrate that the mitogen-activated protein kinases p42 (ERK2) and p44 (ERK1) are also activated by MC4-R follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b965d0e7dc7592dc97e6e1dca75bf8
https://doi.org/10.1016/j.regpep.2004.02.018
https://doi.org/10.1016/j.regpep.2004.02.018
Autor:
Mark T. Goulet, Lihu Yang, Aurawan Vongs, David H. Weinberg, Charles Rosenblum, Changyou Zhou, Feroze Ujjainwalla, Thomas F. Walsh, Matthew J. Wyvratt, Tanya MacNeil, Rubana N. Kalyani, Rui Tang, Lex H.T. Van der Ploeg, Warner Daniel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4431-4435
The discovery and optimization of a new class of non-peptidyl, pyridazinone derived melanocortin subtype-4 receptor agonists is disclosed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d2c34bd9e7e724008bb422d642c2fd
https://doi.org/10.1016/j.bmcl.2003.09.026
https://doi.org/10.1016/j.bmcl.2003.09.026
Autor:
Christopher P. Austin, Doreen E. Cashen, Sheng-Shung Pong, Brian D. Spar, Brett Connolly, Tung Ming Fong, D. Euan MacIntyre, Carina P. Tan, Michael R. Tota, Ravi P. Nargund, R. S. L. Chang, Oksana C. Palyha, Constantin Tamvakopoulos, Deborah L. Drazen, Anthony G. DiLella, Jennifer E. Drisko, David J. Figueroa, Tanya MacNeil, Andreas W. Sailer, David H. Weinberg, Randy J. Nelson, Charles Rosenblum, Cathy R.-R.C. Huang, Rui Tang, Arthur A. Patchett, Xiao-Ming Guan, Hong Yu, George J. Christ, Andrew D. Howard, Lex H.T. Van der Ploeg, William J. Martin, Aurawan Vongs, Iyassu K. Sebhat, Ralph A. Stearns
Publikováno v:
Proceedings of the National Academy of Sciences. 99:11381-11386
By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior. Evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341db11f0e12a0307d07e04176cd4aad
https://doi.org/10.1073/pnas.172378699
https://doi.org/10.1073/pnas.172378699
Autor:
Xiao-Ming Guan, Charles Rosenblum, Hong Yu, Yue Feng, D. Euan MacIntyre, Alison M. Strack, Lex H.T. Van der Ploeg, Christian N. Nunes, Airu S. Chen, Joseph M. Metzger, Linhai Cao, Easter G. Frazier, Jill K. Fisher, Ramon E. Camacho, William Min, Shobhna Gopal-Truter, Aurawan Vongs, Howard Y. Chen, Theodore N. Mellin, Donald J. Marsh, Myrna E. Trumbauer
Publikováno v:
Nature Genetics. 26:97-102
Genetic and pharmacological studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of energy homeostasis. The physiological function of Mc3r, a melanocortin receptor expressed at high levels in the hypothalamus, has rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4ce2d771382f4fed6e69e47dad7818
https://doi.org/10.1038/79254
https://doi.org/10.1038/79254
Autor:
Myung K. Shin, Shirley Chen, Lei Zhu, Xuesong Ouyang, Zhu Shen, Marga Garcia-Calvo, Yanqing Kan, Daphne Szeto, Xiaorui Yao, John Levorse, Dunlu Chen, Jianying Xiao, Jinqi Liu, Aurawan Vongs, Shirly Pinto, Hua V. Lin, Edward J. Kowalik
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54480 (2013)
PLoS ONE
PLoS ONE
Diacylglycerol acyltransferase-1 (DGAT1) is a potential therapeutic target for treatment of obesity and related metabolic diseases. However, the degree of DGAT1 inhibition required for metabolic benefits is unclear. Here we show that partial DGAT1 de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0627cc7b3bf91efdbc080a9e167631
http://europepmc.org/articles/PMC3545956?pdf=render
http://europepmc.org/articles/PMC3545956?pdf=render
Autor:
R. Dennis Miranda, Charles Rosenblum, Aurawan Vongs, Zhong-Sheng Ji, Guy R. Seabrook, Ian J. Reynolds, Hung-Kai Chen, Yadong Huang, Jinny Wong, Karl H. Weisgraber, Robert W. Mahley, Stephen B. Freedman, James G. McGuire
Publikováno v:
Alzheimer's & Dementia. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57be46bd3ec069a17062298c71733ff7
https://doi.org/10.1016/j.jalz.2009.04.468
https://doi.org/10.1016/j.jalz.2009.04.468
Autor:
Yingjie Lai, Ana Teran, Rubana N. Kalyani, M. Angeles Cabello, Ravi P. Nargund, Khaled Barakat, Arthur A. Patchett, David H. Weinberg, Lex H.T. Van der Ploeg, Rui Tang, Tanya MacNeil, Zhixiong Ye, Aurawan Vongs, Iyassu K. Sebhat, Marta Maroto, Tung M. Fong
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(20)
SAR about the piperidine core in a series of MC4R agonists is described. A number of alkyl substituents that furnish compounds with good affinity and functional potency are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700a12560f86e9f672ce92e8752a2def
https://pubmed.ncbi.nlm.nih.gov/17768046
https://pubmed.ncbi.nlm.nih.gov/17768046
Publikováno v:
Science. 260:1926-1928
Three DNA hypomethylation mutants of the flowering plant Arabidopsis thaliana were isolated by screening mutagenized populations for plants containing centromeric repetitive DNA arrays susceptible to digestion by a restriction endonuclease that was s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078ceeb84f878337bdd8ff409bf4470c
https://doi.org/10.1126/science.8316832
https://doi.org/10.1126/science.8316832