Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Aurash, Shahripour"'
Autor:
Gregory L. Adams, Parul S. Pall, Steven M. Grauer, Xiaoping Zhou, Jeanine E. Ballard, Marissa Vavrek, Richard L. Kraus, Pierre Morissette, Nianyu Li, Stefania Colarusso, Elisabetta Bianchi, Anandan Palani, Rebecca Klein, Christopher T. John, Deping Wang, Matthew Tudor, Andrew F. Nolting, Mirlinda Biba, Timothy Nowak, Alexey A. Makarov, Mikhail Reibarkh, Alexei V. Buevich, Wendy Zhong, Erik L. Regalado, Xiao Wang, Qi Gao, Aurash Shahripour, Yuping Zhu, Daniele de Simone, Tommaso Frattarelli, Nicolo’ Maria Pasquini, Paola Magotti, Roberto Iaccarino, Yuxing Li, Kelli Solly, Keun-Joong Lee, Weixun Wang, Feifei Chen, Haoyu Zeng, Jixin Wang, Hilary Regan, Rupesh P. Amin, Christopher P. Regan, Christopher S. Burgey, Darrell A. Henze, Chengzao Sun, David M. Tellers
Publikováno v:
Journal of Medicinal Chemistry. 65:485-496
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ecd04283fe1d38ba43c9ca77818a20e
https://doi.org/10.1021/acs.jmedchem.1c01570
https://doi.org/10.1021/acs.jmedchem.1c01570
Autor:
Thomas J. Tucker, Nianyu Li, Scott P. Salowe, Harold B. Wood, Danila Branca, Alan S. Bass, Rupesh P. Amin, BethAnn Murphy, Aurash Shahripour, Angela Kerekes, Abbas Walji, Nicole Buist, Jeffrey T. Kuethe, Huaibing He, Rodger Tracy, Kenneth A. Koeplinger, Weixun Wang, Bhavana Bhatt, Candice Alleyne, Sookhee Ha, Douglas G. Johns, Elisabetta Bianchi, Chengwei Wu, Peter Orth, Tjerk Bueters, Yusheng Xiong, Hratch J. Zokian, Michael J. Hafey, Mark W. Embrey, John Higgins
Publikováno v:
Journal of Medicinal Chemistry. 64:16770-16800
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) is a key regulator of plasma LDL-cholesterol (LDL-C) and a clinically validated target for the treatment of hypercholesterolemia and coronary artery disease. Starting from second-generation l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01cd83054fdae5294b50a6dbca9f594
https://doi.org/10.1021/acs.jmedchem.1c01599
https://doi.org/10.1021/acs.jmedchem.1c01599
Autor:
Gregory L, Adams, Parul S, Pall, Steven M, Grauer, Xiaoping, Zhou, Jeanine E, Ballard, Marissa, Vavrek, Richard L, Kraus, Pierre, Morissette, Nianyu, Li, Stefania, Colarusso, Elisabetta, Bianchi, Anandan, Palani, Rebecca, Klein, Christopher T, John, Deping, Wang, Matthew, Tudor, Andrew F, Nolting, Mirlinda, Biba, Timothy, Nowak, Alexey A, Makarov, Mikhail, Reibarkh, Alexei V, Buevich, Wendy, Zhong, Erik L, Regalado, Xiao, Wang, Qi, Gao, Aurash, Shahripour, Yuping, Zhu, Daniele, de Simone, Tommaso, Frattarelli, Nicolo' Maria, Pasquini, Paola, Magotti, Roberto, Iaccarino, Yuxing, Li, Kelli, Solly, Keun-Joong, Lee, Weixun, Wang, Feifei, Chen, Haoyu, Zeng, Jixin, Wang, Hilary, Regan, Rupesh P, Amin, Christopher P, Regan, Christopher S, Burgey, Darrell A, Henze, Chengzao, Sun, David M, Tellers
Publikováno v:
Journal of medicinal chemistry. 65(1)
Inhibitor cystine knot peptides, derived from venom, have evolved to block ion channel function but are often toxic when dosed at pharmacologically relevant levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f03f2c5f5119ec1a76291dcc4081ccf8
https://pubmed.ncbi.nlm.nih.gov/34931831
https://pubmed.ncbi.nlm.nih.gov/34931831
Autor:
Shawn P. Walsh, Lee-Yuh Pai, Yuping Zhu, John P. Felix, Caryn Hampton, Xiaoyan Zhou, Melba Hernandez, Brande Thomas-Fowlkes, Richard M. Brochu, Nardos Teumelsan, Gregory J. Kaczorowski, Emma R. Parmee, Maria L. Garcia, Alexander Pasternak, Jinlong Jiang, Sookhee Ha, Sophie Roy, Kathleen A. Sullivan, Haifeng Tang, Lihu Yang, Karen Owens, Reynalda K. de Jesus, Xin Gu, Birgit T. Priest, Barbara Pio, Fa-Xiang Ding, Andrew M. Swensen, Magdalena Alonso-Galicia, Aurash Shahripour, Juliann Ehrhart, Timothy Bailey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5695-5702
Following the discovery of small molecule acyl piperazine ROMK inhibitors, the acyl octahydropyrazino[2,1-c][1,4]oxazine series was identified. This series displays improved ROMK/hERG selectivity, and as a consequence, the resulting ROMK inhibitors d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ba115f699ab80f9a1176691245bcc
https://doi.org/10.1016/j.bmcl.2016.10.064
https://doi.org/10.1016/j.bmcl.2016.10.064
Autor:
Michael J. Forrest, John P. Felix, Lee-Yuh Pai, Melba Hernandez, Yuping Zhu, Aaron Corona, Joseph M. Metzger, Gregory J. Kaczorowski, Nardos Teumelsan, Lihu Yang, Karen Owens, Timothy Bailey, Caryn Hampton, Vincent Tong, Alexander Pasternak, Brande Thomas-Fowlkes, Shawn P. Walsh, Emma R. Parmee, Haifeng Tang, Richard M. Brochu, Maria L. Garcia, Xiaoyan Zhou, Magdalena Alonso-Galicia, Sophie Roy, Birgit T. Priest, Andrew M. Swensen, Aurash Shahripour
Publikováno v:
ACS Medicinal Chemistry Letters. 7:697-701
ROMK, the renal outer medullary potassium channel, is involved in potassium recycling at the thick ascending loop of Henle and potassium secretion at the cortical collecting duct in the kidney nephron. Because of this dual site of action, selective i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415e7bac5379921d8eb6098d8804f901
https://doi.org/10.1021/acsmedchemlett.6b00122
https://doi.org/10.1021/acsmedchemlett.6b00122
Autor:
Lee-Yuh Pai, Yuping Zhu, Richard Visconti, Xiaoyan Zhou, John P. Felix, Melba Hernandez, Jing Chen, Michael Margulis, Nardos Teumelsan, Sophie Roy, Kathleen A. Sullivan, Jessica Liu, Joseph M. Metzger, Aaron Corona, Gregory J. Kaczorowski, Maria L. Garcia, Lihu Yang, Shawn P. Walsh, Birgit T. Priest, Alexander Pasternak, Caryn Hampton, Emma R. Parmee, Vincent Tong, Brande Thomas-Fowlkes, Haifeng Tang, Magdalena Alonso-Galicia, Kashmira Shah, Michael J. Forrest, Richard M. Brochu, Ross Bentley, Sookhee Ha, Karen Owens, Aurash Shahripour, Andrew M. Swensen, Jessica Frie, Adam B. Weinglass, Timothy Bailey
Publikováno v:
ACS Medicinal Chemistry Letters. 6:747-752
A new subseries of ROMK inhibitors exemplified by 28 has been developed from the initial screening hit 1. The excellent selectivity for ROMK inhibition over related ion channels and pharmacokinetic properties across preclinical species support furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c1f32ec6c3f7a915fe446fd2867a1
https://doi.org/10.1021/ml500440u
https://doi.org/10.1021/ml500440u
Autor:
Shawn P. Walsh, Jessica Frie, Nardos Teumelsan, Maria L. Garcia, Karen Owens, Sophie Roy, Caryn Hampton, Reynalda K. de Jesus, Birgit T. Priest, Magdalena Alonso-Galicia, Aurash Shahripour, Richard M. Brochu, Juliann Ehrhart, Andrew M. Swensen, Haifeng Tang, Timothy Bailey, Alexander Pasternak, Lee-Yuh Pai, Yuping Zhu, Lihu Yang, Gregory J. Kaczorowski, John P. Felix, Melba Hernandez, Brande Thomas-Fowlkes, Xiaoyan Zhou
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(9)
Following the discovery of small molecule acyl piperazine ROMK inhibitors and their initial preclinical validation as a novel diuretic agent, our group set out to discover new ROMK inhibitors with reduced risk for QT effects, suitable for further pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fbe8f6e22893cf2f312c30961b9cd2
https://pubmed.ncbi.nlm.nih.gov/27017115
https://pubmed.ncbi.nlm.nih.gov/27017115
Autor:
Roman Herrera, Elizabeth A. Lunney, Kimberly Suzanne Para, Narayanan Surendran, James H. Fergus, Aurash Shahripour, Mark Stephen Plummer, Susan E. Hubbell, Christine Humblet, Barbra H. Stewart, Tomi K. Sawyer, Alan R. Saltiel, Charles J. Stankovic, James S. Marks
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1909-1914
Incorporation of 4-phosphonodifluoromethyl-phenylalanine (F2Pmp) and 4-phosphono-phenylalanine into SH2 targeted peptides and peptidomimetic ligands was found to effect binding affinity and selectivity of these ligands toward the Src and Abl SH2 doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::682bee4b9c10eec067d4cc6736e4bc29
https://doi.org/10.1016/s0960-894x(97)00334-x
https://doi.org/10.1016/s0960-894x(97)00334-x
Autor:
Tomi K. Sawyer, Kimberly Suzanne Para, Alan R. Saltiel, Debra R. Holland, James S. Marks, James H. Fergus, Elizabeth A. Lunney, J. R. Rubin, Christine Humblet, Aurash Shahripour, Mark Stephen Plummer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1107-1112
Based on the X-ray structures of the pp60Src (Src) SH2 domain complexed with two high affinity phosphopeptide ligands (Glu-Pro-Gln-pTyr-Glu-Glu-Ile-Pro-Ile-Tyr-Leu, and Ac-pTyr-Glu- D -Hcy-NH2; Hcy = homocyclohexylalanine), we report herein the desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4756da3aa76638c7b0a50cf0977ec2d9
https://doi.org/10.1016/s0960-894x(97)00190-x
https://doi.org/10.1016/s0960-894x(97)00190-x
Autor:
Kathleen M. Welch, Joan A. Keiser, M. A. Flynn, Aurash Shahripour, Mark Stephen Plummer, Chet Lee, Billy R. Reisdorph, Ron Rubin, Brian Tobias, Jeremy J. Edmunds, Kent A. Berryman, Hussein Hallak, Annette Marian Doherty, S. J. Haleen, E. E. Reynolds, Joseph Thomas Repine, William C. Patt
Publikováno v:
Journal of Medicinal Chemistry. 40:1063-1074
The design of potent and selective non-peptide antagonists of endothelin-1 (ET-1) and its related isopeptides are important tools defining the role of ET in human diseases. In this report we will describe the detailed structure-activity relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a850ffc7dc579c406b79be3cc10fea
https://doi.org/10.1021/jm9606507
https://doi.org/10.1021/jm9606507