Natural Product Synthesis: The Endless Quest for Unreachable Perfection

Autor: Nicolas Fay, Cyrille Kouklovsky, Aurélien de la Torre

Publikováno v: ACS Organic & Inorganic Au, Vol 3, Iss 6, Pp 350-363 (2023)

Externí odkaz: https://doaj.org/article/983ff16687f94508a7585bb6ee80e7ae

Retro-[4+2]/Intramolecular Diels–Alder Cascade Allows a Concise Total Synthesis of Lucidumone

Autor: Aurélien de la Torre, Guanghao Huang, Cyrille Kouklovsky

Publikováno v: Synlett.

Lucidumone is a recently isolated meroterpenoid displaying interesting biological activity. This natural product possesses a complex structure, including a bicyclo[2.2.2]octane possessing 6 contiguous stereogenic centers. Herein, we discuss strategie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a77a59808754e2c6a77d676db376357
https://doi.org/10.1055/s-0042-1751412

Total synthesis of grayanane natural products

Autor: Nicolas Fay, Rémi Blieck, Cyrille Kouklovsky, Aurélien de la Torre

Publikováno v: Beilstein journal of organic chemistry. 18

Grayananes are a broad family of diterpenoids found in Ericaceae plants, comprising more than 160 natural products. Most of them exhibit interesting biological activities, often representative of Ericaceae use in traditional medicine. Over the last 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12dffa735969445bd8ea32251c96865
https://pubmed.ncbi.nlm.nih.gov/36570567

Inverse‐Electron‐Demand Diels‒Alder Reactions of 2‐Pyrones: Bridged Lactones and Beyond

Autor: Cyrille Kouklovsky, Aurélien de la Torre, Guanghao Huang

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, ⟨10.1002/chem.202003980⟩
Chemistry-A European Journal, Wiley-VCH Verlag, In press, ⟨10.1002/chem.202003980⟩

International audience; Inverse‐electron‐demande Diels‐Alder (IEDDA) reactions of electron‐poor 2‐pyrones as electrophilic dienes have been extensively studied in the past fifty years. These reactions provide and efficient access to bridged

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de92bd559d0312f91bba06554f3e394
https://hal.archives-ouvertes.fr/hal-02996238

History of Chemical Routes towards Cyclic Non-Enzymatic Oxygenated Metabolites of Polyunsaturated Fatty Acids

Autor: Aurélien de la Torre, Valérie Bultel-Poncé, Mathieu Candy, Alexandre Guy, Jean-Marie Galano, Thierry Durand, Camille Oger, Claire Cuyamendous

Publikováno v: SYNTHESIS
SYNTHESIS, Georg Thieme Verlag, 2018, 50 (17), pp.3257-3280. ⟨10.1055/s-0036-1589540⟩

Enzymatically formed oxygenated metabolites of polyunsaturated fatty acids (PUFA) are of great interest for the scientific community being mediators and biomarkers in the physiological and pathological regulation of many key biological processes. Mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0274227424dfe2ce710b2cf8458106
https://doi.org/10.1055/s-0036-1589540