Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Aurélien Zarca"'
Autor:
Aurélien Zarca, Claudia Perez, Jelle van den Bor, Jan Paul Bebelman, Joyce Heuninck, Rianna J. F. de Jonker, Thierry Durroux, Henry F. Vischer, Marco Siderius, Martine J. Smit
Publikováno v:
Cells, Vol 10, Iss 3, p 618 (2021)
Background: The atypical chemokine receptor 3 (ACKR3) belongs to the superfamily of G protein-coupled receptors (GPCRs). Unlike classical GPCRs, this receptor does not activate G proteins in most cell types but recruits β-arrestins upon activation.
Externí odkaz:
https://doaj.org/article/a9f82835af6b4ec2a2d3395bee5a36f7
Autor:
Henry F. Vischer, Thierry Durroux, Rianna J F de Jonker, Martine J. Smit, J.P. Bebelman, Claudia Perez, Marco Siderius, Jelle van den Bor, Aurélien Zarca, Joyce Heuninck
Publikováno v:
Cells
Cells, MDPI, 2021, 10 (3), pp.618. ⟨10.3390/cells10030618⟩
Cells, 2021, 10 (3), pp.618. ⟨10.3390/cells10030618⟩
Volume 10
Issue 3
Cells, Vol 10, Iss 618, p 618 (2021)
Cells, 10(3):618, 1-16. MDPI Multidisciplinary Digital Publishing Institute
Zarca, A, Perez, C, van den Bor, J, Bebelman, J P, Heuninck, J, de Jonker, R J F, Durroux, T, Vischer, H F, Siderius, M & Smit, M J 2021, ' Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization ', Cells, vol. 10, no. 3, 618, pp. 1-16 . https://doi.org/10.3390/cells10030618
Cells, MDPI, 2021, 10 (3), pp.618. ⟨10.3390/cells10030618⟩
Cells, 2021, 10 (3), pp.618. ⟨10.3390/cells10030618⟩
Volume 10
Issue 3
Cells, Vol 10, Iss 618, p 618 (2021)
Cells, 10(3):618, 1-16. MDPI Multidisciplinary Digital Publishing Institute
Zarca, A, Perez, C, van den Bor, J, Bebelman, J P, Heuninck, J, de Jonker, R J F, Durroux, T, Vischer, H F, Siderius, M & Smit, M J 2021, ' Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization ', Cells, vol. 10, no. 3, 618, pp. 1-16 . https://doi.org/10.3390/cells10030618
Background: The atypical chemokine receptor 3 (ACKR3) belongs to the superfamily of G protein-coupled receptors (GPCRs). Unlike classical GPCRs, this receptor does not activate G proteins in most cell types but recruits β-arrestins upon activation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e425778b306e89aba4a082271aeb05
https://hal.archives-ouvertes.fr/hal-03193065/file/cells-10-00618-v2.pdf
https://hal.archives-ouvertes.fr/hal-03193065/file/cells-10-00618-v2.pdf
Autor:
Stephen J. Hill, Carsten Hoffmann, Ali Işbilir, Cristina Perpiñá-Viciano, Birgit Caspar, Martine J. Smit, Martin J. Lohse, Laura E. Kilpatrick, Aurélien Zarca
Publikováno v:
Molecular Pharmacology, 98(2), 72-87. American Society for Pharmacology and Experimental Therapeutics
Molecular Pharmacology
Perpiñá-Viciano, C, Işbilir, A, Zarca, A, Caspar, B, Kilpatrick, L E, Hill, S J, Smit, M J, Lohse, M J & Hoffmann, C 2020, ' Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4 ', Molecular Pharmacology, vol. 98, no. 2, pp. 72-87 . https://doi.org/10.1124/MOL.119.118448
Molecular Pharmacology
Perpiñá-Viciano, C, Işbilir, A, Zarca, A, Caspar, B, Kilpatrick, L E, Hill, S J, Smit, M J, Lohse, M J & Hoffmann, C 2020, ' Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4 ', Molecular Pharmacology, vol. 98, no. 2, pp. 72-87 . https://doi.org/10.1124/MOL.119.118448
G protein-coupled receptors (GPCRs) are biologic switches that transduce extracellular stimuli into intracellular responses in the cell. Temporally resolving GPCR transduction pathways is key to understanding how cell signaling occurs. Here, we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f545a3ec6c48d3a361720872e1533c8
https://research.vu.nl/en/publications/ed31ddab-155e-4b2e-a3d0-9039bad482e7
https://research.vu.nl/en/publications/ed31ddab-155e-4b2e-a3d0-9039bad482e7
Autor:
Anneleen Van Hout, Alex Klarenbeek, Hans de Haard, Tom Van Loy, Raimond Heukers, Elisa C. Toffoli, Dominique Schols, Martine J. Smit, Jordi Doijen, Aurélien Zarca, Vladimir Bobkov, Hans J. van der Vliet, Bas van der Woning, Marta Arimont, Magdalena Bialkowska
Publikováno v:
Biochemical Pharmacology, 158, 413-424. Elsevier Inc.
Bobkov, V, Zarca, A M, van Hout, A, Arimont, M, Doijen, J, Bialkowska, M, Toffoli, E, Klarenbeek, A, van der Woning, B, van der Vliet, H J, van Loy, T, de Haard, H, Schols, D, Heukers, R & Smit, M J 2018, ' Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions ', Biochemical Pharmacology, vol. 158, pp. 413-424 . https://doi.org/10.1016/j.bcp.2018.10.014
Biochemical Pharmacology
Bobkov, V, Zarca, A M, Van Hout, A, Arimont, M, Doijen, J, Bialkowska, M, Toffoli, E, Klarenbeek, A, van der Woning, B, van der Vliet, H J, Van Loy, T, de Haard, H, Schols, D, Heukers, R & Smit, M J 2018, ' Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions ', Biochemical Pharmacology, vol. 158, pp. 413-424 . https://doi.org/10.1016/j.bcp.2018.10.014
Bobkov, V, Zarca, A M, van Hout, A, Arimont, M, Doijen, J, Bialkowska, M, Toffoli, E, Klarenbeek, A, van der Woning, B, van der Vliet, H J, van Loy, T, de Haard, H, Schols, D, Heukers, R & Smit, M J 2018, ' Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions ', Biochemical Pharmacology, vol. 158, pp. 413-424 . https://doi.org/10.1016/j.bcp.2018.10.014
Biochemical Pharmacology
Bobkov, V, Zarca, A M, Van Hout, A, Arimont, M, Doijen, J, Bialkowska, M, Toffoli, E, Klarenbeek, A, van der Woning, B, van der Vliet, H J, Van Loy, T, de Haard, H, Schols, D, Heukers, R & Smit, M J 2018, ' Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions ', Biochemical Pharmacology, vol. 158, pp. 413-424 . https://doi.org/10.1016/j.bcp.2018.10.014
Upregulation of the chemokine receptor CXCR4 contributes to the progression and metastasis of both solid and hematological malignancies, rendering this receptor an attractive therapeutic target. Besides the only FDA-approved CXCR4 antagonist Plerixaf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8323cd8a7cc38c9efed3d3b8df36c1a
https://doi.org/10.1016/j.bcp.2018.10.014
https://doi.org/10.1016/j.bcp.2018.10.014
Autor:
Timo W.M. De Groof, Aurélien Zarca, Martine J. Smit, Marta Arimont, Vladimir Bobkov, Hans de Haard, Bas van der Woning
Publikováno v:
Molecular pharmacology, 96(6), 753-764. American Society for Pharmacology and Experimental Therapeutics
Bobkov, V, Arimont, M, Zarca, A, De Groof, T W M, van der Woning, B, de Haard, H & Smit, M J 2019, ' Antibodies Targeting Chemokine Receptors CXCR4 and ACKR3 ', Molecular pharmacology, vol. 96, no. 6, pp. 753-764 . https://doi.org/10.1124/mol.119.116954
Bobkov, V, Arimont, M, Zarca, A, De Groof, T W M, van der Woning, B, de Haard, H & Smit, M J 2019, ' Antibodies Targeting Chemokine Receptors CXCR4 and ACKR3 ', Molecular pharmacology, vol. 96, no. 6, pp. 753-764 . https://doi.org/10.1124/mol.119.116954
Dysregulation of the chemokine system is implicated in a number of autoimmune and inflammatory diseases, as well as cancer. Modulation of chemokine receptor function is a very promising approach for therapeutic intervention. Despite interest from aca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74694493b76a88d40669f20e40db809b
https://pubmed.ncbi.nlm.nih.gov/31481460
https://pubmed.ncbi.nlm.nih.gov/31481460
Autor:
I.J.P. de Esch, Rob Leurs, Stephen J. Hill, M. Gozelle, Marta Arimont, Henry F. Vischer, Birgit Caspar, Aurélien Zarca, Ilze Adlere, Luc Roumen, Stephen J. Briddon, Maikel Wijtmans, Martine J. Smit, Shanliang Sun, C. Perpiñá Viciano, J.P. Bebelman, Carsten Hoffmann, C de Graaf
Publikováno v:
European Journal of Medicinal Chemistry, 162, 631-649. Elsevier Masson SAS
Adlere, I, Sun, S, Zarca, A, Roumen, L, Gozelle, M, Viciano Perpiñá, C, Caspar, B, Arimont, M, Bebelman, J P, Briddon, S J, Hoffmann, C, Hill, S J, Smit, M J, Vischer, H F, Wijtmans, M, de Graaf, C, de Esch, I J P & Leurs, R 2019, ' Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists ', European Journal of Medicinal Chemistry, vol. 162, pp. 631-649 . https://doi.org/10.1016/j.ejmech.2018.10.060
European Journal of Medicinal Chemistry
Adlere, I, Sun, S, Zarca, A, Roumen, L, Gozelle, M, Viciano Perpiñá, C, Caspar, B, Arimont, M, Bebelman, J P, Briddon, S J, Hoffmann, C, Hill, S J, Smit, M J, Vischer, H F, Wijtmans, M, de Graaf, C, de Esch, I J P & Leurs, R 2019, ' Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists ', European Journal of Medicinal Chemistry, vol. 162, pp. 631-649 . https://doi.org/10.1016/j.ejmech.2018.10.060
European Journal of Medicinal Chemistry
Using the available structural information of the chemokine receptor CXCR4, we present hit finding and hit exploration studies that make use of virtual fragment screening, design, synthesis and structure activity relationship (SAR) studies. Fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98f9353f81b3d79daa353540428ab40
https://research.vu.nl/en/publications/45d9472d-608d-4e73-87f3-0d395b700372
https://research.vu.nl/en/publications/45d9472d-608d-4e73-87f3-0d395b700372