Replication fork polarity gradients revealed by megabase-sized U-shaped replication timing domains in human cell lines.

Autor: Antoine Baker, Benjamin Audit, Chun-Long Chen, Benoit Moindrot, Antoine Leleu, Guillaume Guilbaud, Aurélien Rappailles, Cédric Vaillant, Arach Goldar, Fabien Mongelard, Yves d'Aubenton-Carafa, Olivier Hyrien, Claude Thermes, Alain Arneodo

Publikováno v: PLoS Computational Biology, Vol 8, Iss 4, p e1002443 (2012)

In higher eukaryotes, replication program specification in different cell types remains to be fully understood. We show for seven human cell lines that about half of the genome is divided in domains that display a characteristic U-shaped replication

Externí odkaz: https://doaj.org/article/7d11a983c8a84058b54c32765c749815

Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations OPEN

Autor: Benjamin Audit, Olivier Hyrien, Françoise Argoul, Malik Kahli, Nataliya Petryk, Arach Goldar, Aurélien Rappailles, Guillaume Guilbaud, Alain Arneodo

Publikováno v: Scientific Reports
Scientific Reports, 2016, 6 (22), pp.22469 (1-8). ⟨10.1038/srep22469⟩
Scientific Reports, Nature Publishing Group, 2016, 6 (22), pp.22469 (1-8). ⟨10.1038/srep22469⟩
Scientific Reports, Nature Publishing Group, 2016, 6 (22), pp.22469 (1-8). 〈10.1038/srep22469〉
Goldar, A, Arneodo, A, Audit, B, Argoul, F, Rappailles, A, Guilbaud, G, Petryk, N, Kahli, M & Hyrien, O 2016, ' Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations ', Scientific Reports, vol. 6, 22469 . https://doi.org/10.1038/srep22469

We propose a non-local model of DNA replication that takes into account the observed uncertainty on the position and time of replication initiation in eukaryote cell populations. By picturing replication initiation as a two-state system and consideri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0feaf0cea4113ffc5db4df378ff4c529
https://hal.science/hal-01412574/file/GoldarSRep2016.pdf

Relating mammalian replication program to large-scale chromatin folding

Autor: Rasha E. Boulos, Chun-Long Chen, Benjamin Audit, Aurélien Rappailles, Olivier Hyrien, Arach Goldar, Antoine Baker, Hanna Julienne, Guillaume Guilbaud, Claude Thermes, Alain Arneodo, Yves d'Aubenton-Carafa

Publikováno v: BCB

We review the existence of a new type of megabase-sized replication domains along the human genome. These domains are revealed in 7 somatic cell types by U-shaped patterns in the replication timing profiles. In the germline, these domains appear as N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e1039ae93a3aff8813795a18c454c04
https://doi.org/10.1145/2506583.2506699

From Simple Bacterial and Archaeal Replicons to Replication N/U-Domains

Autor: Antoine Baker, Guillaume Guilbaud, Alain Arneodo, Yves d'Aubenton-Carafa, Olivier Hyrien, Chun-Long Chen, Benjamin Audit, Emilie Ma, Arach Goldar, Nataliya Petryk, Malik Kahli, Claude Thermes, Aurélien Rappailles

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2013, 425 (23), pp.4673-4689. ⟨10.1016/j.jmb.2013.09.021⟩
Journal of Molecular Biology, 2013, 425 (23), pp.4673-4689. ⟨10.1016/j.jmb.2013.09.021⟩
Journal of Molecular Biology, Elsevier, 2013, 425 (23), pp.4673-4689. 〈10.1016/j.jmb.2013.09.021〉

The Replicon Theory proposed 50 years ago has proven to apply for replicons of the three domains of life. Here, we review our knowledge of genome organization into single and multiple replicons in bacteria, archaea and eukarya. Bacterial and archaeal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c55f001ef12395c6285030981c5212
https://hal.archives-ouvertes.fr/hal-01557075

Evidence for Sequential and Increasing Activation of Replication Origins along Replication Timing Gradients in the Human Genome

Autor: Alain Arneodo, Guillaume Guilbaud, Arach Goldar, Olivier Hyrien, Antoine Baker, Claude Thermes, Yves d'Aubenton-Carafa, Chun-Long Chen, Benjamin Audit, Aurélien Rappailles

Publikováno v: PLoS Computational Biology
PLoS Computational Biology, 2011, 7 (12), pp.e1002322. ⟨10.1371/journal.pcbi.1002322⟩
PLoS Computational Biology, Vol 7, Iss 12, p e1002322 (2011)
PLoS Computational Biology, Public Library of Science, 2011, 7 (12), pp.e1002322. ⟨10.1371/journal.pcbi.1002322⟩

Genome-wide replication timing studies have suggested that mammalian chromosomes consist of megabase-scale domains of coordinated origin firing separated by large originless transition regions. Here, we report a quantitative genome-wide analysis of D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e4feb14924e00d8e857b58d465e13a
http://europepmc.org/articles/PMC3248390